Perfil eletrocardiográfico e conteúdo glicogênico muscular de ratos tratados com nandrolona

Silva, Carlos Alberto da; Pardi, Adriano Cesar Rocco; Gonçalves, Talita Moral; Borin, Sergio Henrique

doi:10.1590/s0066-782x2010005000144

Cited by 7 publications

(3 citation statements)

References 28 publications

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“…This model of pain is, therefore, sensitive to the action of NSAIDs [43, 44]. For Agrimonia eupatoria , the results suggest analgesic properties through peripheral mechanisms.…”

Section: Resultsmentioning

confidence: 99%

Antioxidant, Anti-Inflammatory, and Analgesic Activities ofAgrimonia eupatoriaL. Infusion

Santos

Costa

Ferreira

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Agrimony (Agrimonia eupatoria L.) (Ae) is used in traditional medicine to treat inflammatory and oxidative related diseases. Therefore, this study focuses on the anti-inflammatory and analgesic potential of Ae infusion (AeI). Phenolic compounds characterization was achieved by HPLC-PDA-ESI/MSn. To evaluate antioxidant potential, 2,2-diphenyl-1-picrylhydrazyl (DPPH), superoxide anion, hydroxyl radical, and SNAP assays were used. In vitro anti-inflammatory activity of AeI was investigated in LPS-stimulated macrophages by measuring the NO production. In vivo anti-inflammatory activity was validated using the mouse carrageenan-induced paw edema model. Peripheral and central analgesic potential was evaluated using the acetic acid-induced writhing and hot-plate tests, respectively, as well as the formalin assay to assess both activities. The safety profile was disclosed in vitro and in vivo, using MTT and hematoxylin assays, respectively. Vitexin, quercetin O-galloyl-hexoside, and kaempferol O-acetyl-hexosyl-rhamnoside were referred to in this species for the first time. AeI and mainly AePF (Ae polyphenolic fraction) showed a significant antiradical activity against all tested radicals. Both AeI and AePF decreased NO levels in vitro, AePF being more active than AeI. In vivo anti-inflammatory and analgesic activities were verified for both samples at concentrations devoid of toxicity. Agrimony infusion and, mainly, AePF are potential sources of antiradical and anti-inflammatory polyphenols.

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“…This model of pain is, therefore, sensitive to the action of NSAIDs [43, 44]. For Agrimonia eupatoria , the results suggest analgesic properties through peripheral mechanisms.…”

Section: Resultsmentioning

confidence: 99%

Antioxidant, Anti-Inflammatory, and Analgesic Activities ofAgrimonia eupatoriaL. Infusion

Santos

Costa

Ferreira

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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“…Dessa forma, a cardiologia vivenciou o rápido avanço nos cuidados relacionados às cardiopatias, em parte, devido à intensa pesquisa experimental na área (Silva et al, 2010).…”

Section: Introductionunclassified

Acompanhamento eletrocardiográfico no desenvolvimento de ratos Wistar

Pezolato

Mascarin

Dias

et al. 2017

Arq. Bras. Med. Vet. Zootec.

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RESUMOA atividade elétrica cardíaca pode ser registrada por meio do eletrocardiograma (ECG), registro capaz de captar as alterações do percurso elétrico. Na literatura científica, não existe descrição de padrões eletrocardiográficos de ratos Wistar desde a fase de recém-nascidos até serem considerados envelhecidos. O objetivo do presente estudo foi avaliar o padrão eletrocardiográfico de ratos Wistar desde a fase de recém-nascidos até serem considerados envelhecidos, no intuito de que os resultados possam contribuir como referencial dos padrões da espécie. Foram utilizados ratos Rattus novergicus albinus, da linhagem Wistar. Os ratos foram divididos em cinco grupos experimentais, sendo definidos de acordo com a idade e assim denominados: grupo 21 dias (21D), dois meses (2M), três meses (3M), sete meses (7M) e 18 meses (18M), sendo n=20 por grupo. Para a realização do ECG, eletrodos conectados aos canais do eletrocardiógrafo foram posicionados nos animais e captaram o sinal elétrico do coração em seis derivações. Os dados foram agrupados e submetidos a comparação por meio de ANOVA e teste de Tukey-Kramer, P≤0,05. Os resultados mostraram que, de forma geral, as modulações ao longo do processo de envelhecimento diante dos parâmetros relacionados ao ECG se iniciam a partir do período 2M, com aparente estabilidade até 3M e/ou 7M, seguindo por exacerbação das modulações em 7M e/ou 18M, a depender da variável eletrocardiográfica em questão. Em relação à frequência cardíaca (FC), concomitantemente, nota-se um padrão similar, ou seja, diminuição dela a partir do período 2M, com estabilidade até 7M, seguindo por diminuição mais pronunciada em 18M. Os resultados sugerem que, devido ao processo de envelhecimento, o coração de ratos Wistar apresenta modificações na condução do estímulo elétrico, bem como redução na FC, fatores que merecem atenção enquanto indicadores de inclusão/exclusão de animais em grupos experimentais por parte de pesquisadores que utilizam a referida espécie como modelo de estudo. Palavras-chave: eletrocardiograma, ECG, ratos, envelhecimento ABSTRACT The cardiac electrical activity can be recorded through the electrocardiogram (ECG), this recording is

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“…Da Silva et al46 evaluated the effects of nandrolone decanoate on the electrocardiographic profile, glycogen content and total-protein profile of skeletal and cardiac muscles, as well as the plasma albumin concentrations in rats, concluding that major cardiac changes are triggered at an early stage, which indicates a hierarchy in the sequence of changes that compromise the homeostasis of the body. Diogo et al47 evaluated the possible association between NSAIDs and Contrast-Induced Nephropathies and conclude that there was no association.…”

Section: Introductionmentioning

confidence: 99%

A survey of recently published cardiovascular, hematological and pneumological original articles in the Brazilian scientific press

Patel¹,

Caramelli²,

Gomes³

2011

Clinics

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Recent original scientific contributions published in selected Brazilian periodicals and classifiable under cardiovascular and pulmonary subject categories cover a wide range of sub specialties, both clinical and exprimental. Because they appear in journals with only recently enhanced visibility, we have decided to highlight a number of specific items appeared in four Brazilian journals, because we understand that this is an important subsidy to keep our readership adequately informed. These papers cover extensive sub-areas in both fields.

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Perfil eletrocardiográfico e conteúdo glicogênico muscular de ratos tratados com nandrolona

Abstract: Background: We considered both the indiscriminate use of steroids by top athletes and by physically active individuals.

Cited by 7 publications

References 28 publications

Antioxidant, Anti-Inflammatory, and Analgesic Activities ofAgrimonia eupatoriaL. Infusion

Antioxidant, Anti-Inflammatory, and Analgesic Activities ofAgrimonia eupatoriaL. Infusion

Acompanhamento eletrocardiográfico no desenvolvimento de ratos Wistar

A survey of recently published cardiovascular, hematological and pneumological original articles in the Brazilian scientific press

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