Perfil lipídico de pacientes com alto risco para eventos cardiovasculares na prática clínica diária

Abstract

Although there are specific guidelines regarding the treatment of dyslipidemia in highly risk patients, these recommendations are usually inadequately followed. The aim of this study is to investigate risk factors in patients with increased cardiovascular risk currently treated in Brazil and Venezuela. Medical charts of 412 patients were selected in 4 institutions. Patients were divided into groups according to the use of lipid-lowering drugs (LLD), particularly statins. Patients who did not use LLD showed higher levels of total cholesterol (p< 0.001), LDL cholesterol (p< 0,001) and HDL cholesterol (p< 0.001), besides lower levels of triglycerides (p< 0.001). The use of statins was associated with a decrease in levels of total cholesterol (from 251.0 +/- 40.0 to 196.0 +/- 46.0), LDL cholesterol (from 168.0 +/- 36.0 to 116.0 +/- 39.0), HDL cholesterol (from 51.0 +/- 46.0 to 46.0 +/- 12.0) and triglycerides (from 181.0 +/- 120.0 to 160.0 +/-79.0). Finally, only a small percentage of patients, even those under treatment with LLD, showed cholesterol levels according to currently available guidelines. Therefore, although the guidelines for the treatment of dyslipidemia are widely known, only a small percentage of patients achieve adequate levels of cholesterol. It is necessary to decrease lipid levels of these patients by increasing the dose of the statins or using a second drug.

Análise do perfil lipídico de mulheres idosas em Curitiba - Paraná

“…As for the women in the group that self-reported undergoing lipid-lowering therapy, 45.8% to 49.3% of them presented values that were above the lipid goal regarding total cholesterol, LDL-C and triglycerides and 25.4% of them were classified as presenting HDL-C levels that were lower than the lipid goal (>40.0 mg/dl). Recent studies have shown similar results to the ones found in the present study, in which a large number of individuals, although undergoing lipid-lowering therapy, did not reach the recommended lipid goals 7,9,10 .…”

“…One of the main risk factors for CVD is dyslipidemia, due to its association with the development of CVD 3 and the progression of atherosclerosis in the elderly 4 . However, studies concerning its frequency in the Brazilian population are still scarce, mainly among the elderly [5][6][7] .…”

Risk factors in patients with type 2 diabetes mellitus

“…Such lipid profile, accompanied by the use of medication, strongly suggests inadequate diet and lack of physical activity. However, the need for a better control of lipid levels has to be considered, through a more effective and safe follow-up of the medications in use, which can even require dosage alteration, as well as the association of hypolipemiants (18) .…”

Atividades de educação nutricional: uma experiência com trabalhadores de uma empresa de plantio e processamento de eucalipto.

“…Entre os problemas que têm acometido os indivíduos se incluem as doenças cardiovasculares, consideradas como a maior causa de mortalidade no mundo. Estudos demonstram que existem vários fatores diretamente relacionados à elevada incidência de eventos cardiovasculares, principalmente a hipertensão arterial, as dislipidemias e o diabetes mellitus (GRILLO et al, 2005;MOREIRA et al, 2006). Tais distúrbios podem acometer os indivíduos de maneira isolada ou associada, sendo esta última conhecida como síndrome metabólica, que constitui um fator de risco para o desenvolvimento das doenças cardiovasculares .…”