Prolactinomas e densidade mineral óssea em homens

Naliato, Erika Cesar de Oliveira; Farias, Maria Lúcia Fleiuss; Violante, A

doi:10.1590/s0004-27302005000200004

Cited by 4 publications

(3 citation statements)

References 54 publications

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“…To date, and to our knowledge, few data are available on the impact of hyperprolactinemia on bone metabolism in children and adolescents [20]. In adult patients, discussions are ongoing on the possibility of a direct effect or an effect mediated via hypoestrogenism [21,22]. Colao et al [23] found significantly lower values of bone mineral density in adolescent patients with hyperprolactinemia than in their sex- and age-matched controls and also lower bone mineral density values corrected for age in the adolescent patients with hyperprolactinemia than in the young adult patients.…”

Section: Clinical Featuresmentioning

confidence: 99%

Prolactinoma in Children and Adolescents

et al. 2009

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The evolution of prolactinomas in children and adolescents continues to be controversial. Girls have more prevalence of microprolactinomas and their signs and symptoms are related to hyperprolactinemia and the resulting hypogonadotrophic hypogonadism. In males, the greater incidence of macroadenomas results in the presence of neuro-ophthalmologic signs. The larger prevalence of macroadenomas in males is consistent with findings in adults and would not be related to a later diagnosis. In patients with asymptomatic hyperprolactinemia, the presence of altered proportions of PRL isoforms should be evaluated. The diagnosis of prolactinoma requires both radiographic evidence of pituitary adenoma and laboratory analysis documenting the presence of sustained hyperprolactinemia. Because of their effectiveness and tolerance, dopaminergic agonists are the initial therapy of choice in pediatric age patients. Finally, molecular biology and genetic studies have brought new insights into the pathogenesis, clinical behavior and different therapeutic responses.

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Section: Clinical Featuresmentioning

confidence: 99%

Prolactinoma in Children and Adolescents

et al. 2009

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“…Sabe-se que a massa óssea diminui a partir dos 30 anos de 1 a 2% nas mulheres e de 0,3 a 1% nos homens. A massa óssea é maior nos homens do que nas mulheres, pois eles possuem esqueletos maiores; além disso, o período de perda óssea se inicia mais tardiamente nos homens do que nas mulheres, cerca de uma década depois 12 . Estudos têm demonstrado que um dos principais fatores na prevenção de doenças crônicas não transmissíveis, tais como osteoporose e fraturas subsequentes no futuro, é a tentativa de atingir o pico ideal de massa óssea durante a adolescência ou no final da maturação esquelética 13,14 .…”

Section: Introductionunclassified

Impact of skeletal maturation on bone metabolism biomarkers and bone mineral density in healthy Brazilian male adolescents

Silva¹,

Goldberg²,

Nga³

et al. 2011

J Pediatr (Rio J)

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Objective: To evaluate the behavior of biomarkers of bone formation and resorption in healthy male Brazilian adolescents according to their biological maturation.Methods: Eighty-seven volunteers were divided into age groups according to bone age (BA): 10-12 years (n = 25), 13-15 years (n = 36), and 16-18 years (n = 26). Weight (kg), height (m), body mass index (kg/m 2 ), calcium intake from 3 days assessed by 24-h food recall (mg/day), pubertal event evaluation by Tanner criteria, and serum biomarker levels (osteocalcin [OC] [ng/mL], bone alkaline phosphatase [BAP] [U/L], and serum carboxyterminal telopeptide [S-CTx] [ng/mL]) were recorded and correlated to bone mineral density (BMD) (g/cm 2 ) measured by dual energy X-ray absorptiometry of the lumbar spine, proximal femur, and whole body. Results:Biomarkers showed similar behaviors, presenting higher median values in the 13-15 year group (BAP = 154.71 U/L, OC = 43.0 ng/mL, S-CTx = 2.09 ng/mL; p < 0.01) and when adolescents were in the pubertal stage G4. Median biomarker values decreased with advancing BA and sexual maturation. Biomarker values showed parallelism with peak height velocity, and, interestingly, bone formation biomarkers indicated significant negative correlation with BMD in the different evaluated locations, i.e., higher BMD values correlated with lower bone biomarker values.Conclusions: This is the first study of healthy Brazilian adolescents with rigid and careful inclusion and exclusion criteria to assess the correlation of bone markers and BMD with biological maturation indicators. Our results can help understand bone turnover and monitor bone metabolism. J Pediatr (Rio J). 2011;87(5):450-6:Bone biomarkers, adolescents, bone mineral density, bone age. ResumoObjetivo: Avaliar o comportamento de biomarcadores de formação e reabsorção óssea em adolescentes brasileiros em função da sua maturação biológica.Métodos: Oitenta e sete voluntários foram divididos em grupos segundo a idade óssea (IO): 10-12 anos (n = 25), 13-15 anos (n = 36) e 16-18 anos (n = 26). Foram analisados peso (kg), estatura (m), índice de massa corporal (kg/m 2 ), ingestão de cálcio de 3 dias (mg/dia), avaliação dos eventos pubertários pelos critérios de Tanner, níveis dos biomarcadores [osteocalcina (OC) (ng/mL), fosfatase alcalina óssea (FAO) (U/L), telopeptídeo carboxiterminal sérico (S-CTx) (ng/mL)] e sua correlação com a densidade mineral óssea (DMO) (g/cm 2 ) por atenuação de raios X de dupla energia da coluna lombar, do fêmur proximal e de corpo total.Resultados: Os biomarcadores mostraram comportamento semelhante, apresentando medianas elevadas dos 13 aos 15 anos (FAO = 154,71 U/L, OC = 43,0 ng/mL, S-CTx = 2,09 ng/mL; p < 0,01) e no estágio puberal G4. As medianas decresceram com o avançar da IO e da maturação sexual. Os níveis dos biomarcadores mostraram paralelismo com pico de velocidade em estatura, e, curiosamente, os biomarcadores de formação indicaram correlação negativa com a DMO, isto é, valores de DMO elevados se correlacionaram com valores baixos dos...

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“…As principais estão assinaladas na Tabela 1. Haveria, portanto, redução das concentrações séricas desse hormônio (Naliato et al, 2005). No entanto, há pacientes que não respondem bem ao tratamento, continuando com o problema.…”

Section: Hiperprolactinemiaunclassified

Expressão gênica da prolactina e seus receptores na hipófise e no útero de camundongo fêmea tratado com metoclopramida

Amaral¹

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Prolactinomas e densidade mineral óssea em homens

Cited by 4 publications

References 54 publications

Prolactinoma in Children and Adolescents

Prolactinoma in Children and Adolescents

Impact of skeletal maturation on bone metabolism biomarkers and bone mineral density in healthy Brazilian male adolescents

Expressão gênica da prolactina e seus receptores na hipófise e no útero de camundongo fêmea tratado com metoclopramida

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