Prevalência de doença tireoideana em pacientes com diabetes tipo 1

Ramos, Aline Sharlon Maciel Batista; Costa, Antônio Celso Spı́nola; Benício, Ana Valéria L.; Ramos, André Luiz C.; Silva, Carla Rameri A.; Carvalho, Cinthya Rocha De; Melo, Cícero Ludgero Alcindo de; Filho, Sanlio C. de Oliveira; Lima, Vicente Júlio B. de; Cruz, Thomaz

doi:10.1590/s0004-27302003000200011

Cited by 13 publications

(14 citation statements)

References 20 publications

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“…Concerning screening recommendations, Ramos et al [17] screened patients with thyroiditis using only anti-TPO, and encountered lower prevalence of AITD then Rodrigues [18], which assessed both antibodies (20.6% and 35.5%, respectively), suggesting that there is a loss of diagnosis of AITD when using only anti-TPO antibodies. In our study, if we only measured one antibody, we would have missed approximately one third of AITD.…”

Section: Discussionmentioning

confidence: 99%

Thyroid function and autoimmunity in children and adolescents with Type 1 Diabetes Mellitus

Riquetto

Noronha

Matsuo

et al. 2015

Diabetes Research and Clinical Practice

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Section: Discussionmentioning

confidence: 99%

Thyroid function and autoimmunity in children and adolescents with Type 1 Diabetes Mellitus

Riquetto

Noronha

Matsuo

et al. 2015

Diabetes Research and Clinical Practice

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“…In the study by Ramos et al [11], where 126 patients with T1DM were evaluated, the prevalence of TD was 20.6%. However, they considered a positive test for autoimmunity as TD.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of thyroid dysfunction in patients with diabetes mellitus

Palma

Pavesi

Nogueira

et al. 2013

Diabetol Metab Syndr

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BackgroundDiabetes mellitus (DM) and thyroid dysfunction (TD) are the two most common endocrine disorders in clinical practice. The unrecognized TD may adversely affect the metabolic control and add more risk to an already predisposing scenario for cardiovascular diseases. The objective of this study was to investigate the prevalence of TD in patients with type 1 and type 2 diabetes mellitus (T1DM and T2DM).MethodsThis is an observational cross-sectional study. Three hundred eighty-six (386) patients with T1DM or T2DM that regularly attended the outpatient clinic of the Diabetes unit, Hospital Universitário Pedro Ernesto, participated in the study. All patients underwent a clinical and laboratory evaluation. Thyroid dysfunction was classified as clinical hypothyroidism (C-Hypo) if TSH > 4.20 μUI/mL and FT4 < 0.93 ng/dL; Subclinical hypothyroidism (SC-Hypo) if TSH > 4.20 μUI/ml and FT4 ranged from 0.93 to 1.7 ng/dL; Subclinical hyperthyroidism (SC-Hyper) if TSH < 0.27 μUI/ml and FT4 in the normal range (0.93 and 1.7 ng/dL) and Clinical hyperthyroidism (C-Hyper) if TSH < 0.27 μUI/ml and FT4 > 1.7 μUI/mL. Autoimmunity were diagnosed when anti-TPO levels were greater than 34 IU/mL. The positive autoimmunity was not considered as a criterion of thyroid dysfunction.ResultsThe prevalence of TD in all diabetic patients was 14,7%. In patients who had not or denied prior TD the frequency of TD was 13%. The most frequently TD was subclinical hypothyroidism, in 13% of patients with T1DM and in 12% of patients with T2DM. The prevalence of anti-TPO antibodies was 10.8%. Forty-four (11.2%) new cases of TD were diagnosed during the clinical evaluation. The forty-nine patients with prior TD, 50% with T1DM and 76% with T2DM were with normal TSH levels.ConclusionsWe conclude that screening for thyroid disease among patients with diabetes mellitus should be routinely performed considering the prevalence of new cases diagnosed and the possible aggravation the classical risk factors such as hypertension and dyslipidemia, arising from an undiagnosed thyroid dysfunction.

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“…Além disso, esse aumento da prevalência, quando comparado aos valores encontrados em estudos de duas a três décadas atrás (9,17), foi observado em outros estudos atuais (8,14,19,25). Embora tal achado possa ser real aumento da prevalência destas doenças, deve-se ressaltar que pode ser reflexo apenas de melhor sensibilidade dos métodos atuais na detecção dos portadores de anticorpos contra a tireóide.…”

Section: Discussionunclassified

“…No Brasil, essa mesma divergência na prevalência de DAT no DM1 tem-se reproduzido nos poucos estudos realizados, com alguns autores encontrando números que variam de 9% a 33% (16)(17)(18)(19). Novos estudos epidemiológicos contribuiriam para o conhecimento da real prevalência da DAT entre os DM1 e em seus familiares e também para a comprovação de influências da associação entre as doenças auto-imunes sobre o curso de cada doença.…”

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Prevalência de disfunção tireoidiana e anticorpos antitireoidianos em pacientes portadores de diabetes melito tipo 1 e em seus familiares de primeiro grau

Rodrigues¹,

Gonçalves²,

Jorge³

2008

Arq Bras Endocrinol Metab

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RESUMOO diabetes melito tipo 1 (dM1) freqüentemente encontra-se associado à doença auto-imune da tireóide (dAt). A prevalência de dAt varia de 3% a 50% entre diabéticos, e é maior também entre seus familiares, comparada à população geral. Objetivos: Investigar a prevalência da dAt em pacientes com dM1, avaliar possíveis diferenças de comportamento clínico-evolutivo do dM1 entre diabéticos com e sem dAt e estudar a prevalência de dAt nos familiares dos pacientes diabéticos. Materiais e Métodos: Os prontuários de 124 diabéticos tipo 1 foram revisados e coletados os dados referentes à função e aos anticorpos tireoidianos; pacientes com e sem dAt foram comparados em relação à média de Hb glicosilada, complicações agudas e crônicas, idade ao diagnóstico e tempo de evolução do dM, dose de insulina e outros. um estudo caso-controle foi realizado com 54 familiares em primeiro grau destes pacientes; foram avaliadas a função tireoidiana e a presença de anticorpos antitireoidianos em 32 familiares de diabéticos sem dAt e 22 familiares de diabéticos com dAt. Resultados: As prevalências de dAt e de disfunção hormonal entre os diabéticos foram de 35,5% e 19,3%, respectivamente. quanto à avaliação dos parâmetros de evolução do dM1, comportamento clínico e controle metabólico não houve diferenças significantes entre os diabé-ticos com e sem dAt. Houve maior prevalência de dAt nos familiares de diabéticos com dAt do que no grupo dos familiares dos diabéticos sem dAt, sem diferença significativa quanto à prevalência de disfunção hormonal. Conclusões: A prevalência de doença auto-imune de tireóide em diabéticos e em seus familiares é elevada, justificando-se, nesses casos, a investigação rotineira da função tireoidiana, particularmente dos familiares de primeiro grau de diabéticos com dAt. diabetes Mellius type 1 (dM1) is frequently associated to Autoimmune thyroid disease (AItd). the prevalence of AItd among diabetic patients varies between 3 to 50% and the incidence is also big among their family members, when compared to the population in general. Objectives: to investigate the prevalence of AItd in patients with dM1; to evaluate possible differences concerning the clinical-evolutive behavior of dM1 among diabetic patients with or without AItd and to study the prevalence of AItd among the diabetes patients' relatives. Materials and Methods: 124 prontuaries of diabetic patients (type 1) were revised and data was gathered concerning the thyroid function and the anti-thyroid antibodies. Patients with and without AItd were compared in relation to the level of glycosylated hemoglobin, the presence of acute and chronic complications, the age of the patient at the time of the

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Prevalência de doença tireoideana em pacientes com diabetes tipo 1

Cited by 13 publications

References 20 publications

Thyroid function and autoimmunity in children and adolescents with Type 1 Diabetes Mellitus

Thyroid function and autoimmunity in children and adolescents with Type 1 Diabetes Mellitus

Prevalence of thyroid dysfunction in patients with diabetes mellitus

Prevalência de disfunção tireoidiana e anticorpos antitireoidianos em pacientes portadores de diabetes melito tipo 1 e em seus familiares de primeiro grau

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