Endothelial dysfunction in children with type 1 diabetes mellitus

Nascimento, Antonella Márcia Mercadante de Albuquerque do; Sequeira, Inês Jorge da Silva; Vasconcelos, Daniel França; Gandolfi, Lenora; Pratesi, Riccardo; Nóbrega, Yanna Karla de Medeiros

doi:10.1590/2359-3997000000271

Cited by 18 publications

(11 citation statements)

References 30 publications

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“…This may be explained by that increased glycemic state is associated with increased vasoconstriction and hypertension due to inflammatory state that induces oxidative stress that alters nitric oxide secretion and degradation and finally has a deleterious effect on vascular endothelial cells. Our results concerning hyperglycemia and increased blood pressure are in agreement with a previous study [ 25 ]. Furthermore, this study also clarifies the role of apelin in the occurrence of diabetic nephropathy.…”

Section: Discussionsupporting

confidence: 94%

“…Also, we found significant positive correlations between serum apelin and serum cholesterol, LDL and TG in diabetic patients. In support of these results, other study found statistical differences between diabetic and non-diabetic groups as regards serum levels of TG and cholesterol [ 25 ]. Also, other study reported the same results as regards serum TG [ 13 ].…”

Section: Discussionsupporting

confidence: 73%

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Serum Apelin: A New Marker of Early Atherosclerosis in Children with Type 1 Diabetes Mellitus

Sabry¹,

Wakeel²,

El-Kassas³

et al. 2018

Open Access Maced J Med Sci

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INTRODUCTION:Type 1 diabetes mellitus (T1DM) is one of the most common chronic diseases in children that may be complicated by micro or macrovascular complications. Measurement of the carotid intima-media thickness (CIMT) allows the early detection of atherosclerotic alterations of blood vessels that may complicate T1DM.SUBJECTS AND METHODS:This study is a case-control study. Participants were classified into two groups. The first group included 40 children with T1DM and the second group included 30 matched healthy controls. The studied cases were recruited from Endocrinology and Diabetology Unit, Pediatric Hospital, Ain Shams University. Serum apelin, cholesterol, TG, LDL were measured for every case. Also, albumin level was analyzed in urine. Measurement of the carotid intima-media thickness (CIMT) was done for all cases.RESULTS:Comparison between T1DM patients and controls revealed that serum apelin, cholesterol, TG, LDL and albuminuria were significantly increased in cases compared to controls. Significant positive correlations were detected between HbA1C, albuminuria and lipid profile with apelin in the diabetic group (p < 0.05). CIMT has significant positive correlation with serum apelin levels (r = 0.36, p = 0.05). Also, this study found positive correlations between CIMT and some variables as LDL, SBP z-score and duration of the illness.CONCLUSION:Increased levels of serum apelin in T1DM patients may be considered as predicting factor for the ongoing development of vascular sequels. This study highlighted the possible validity of apelin assay as an early predictor of atherosclerosis in T1DM children. Evaluating CIMT in these patients is of at most important for early detection of subclinical atherosclerosis.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 73%

Serum Apelin: A New Marker of Early Atherosclerosis in Children with Type 1 Diabetes Mellitus

Sabry¹,

Wakeel²,

El-Kassas³

et al. 2018

Open Access Maced J Med Sci

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“…Several surrogate indices are used in clinical practice to assess early vascular abnormalities ( Table 3 ). Young patients with T1D showed delayed or reduced brachial artery flow mediated dilatation (FMD) reactivity and higher carotid femoral pulse wave velocity (PWV), as compared to healthy controls [ 53 , 54 , 59 , 68 , 78 , 91 , 92 , 93 , 94 , 95 , 96 ]. On the other hand, Bradley et al demonstrated that carotid-radial PWV, but not carotid-femoral PWV, is higher in adolescents with T1D than in healthy controls [ 93 ].…”

Section: Vascular Tests To Unveil Early CV Risk In Children and Admentioning

confidence: 99%

The Impact of Diabetes Mellitus on Cardiovascular Risk Onset in Children and Adolescents

Pastore

Bolla

Montefusco

et al. 2020

IJMS

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The prevalence of diabetes mellitus is rising among children and adolescents worldwide. Cardiovascular diseases are the main cause of morbidity and mortality in diabetic patients. We review the impact of diabetes on establishing, during childhood and adolescence, the premises for cardiovascular diseases later in life. Interestingly, it seems that hyperglycemia is not the only factor that establishes an increased cardiovascular risk in adolescence. Other factors have been recognized to play a role in triggering the onset of latent cardiovascular diseases in the pediatric population. Among these cardiovascular risk factors, some are modifiable: glucose variability, hypoglycemia, obesity, insulin resistance, waist circumference, hypertension, dyslipidemia, smoking alcohol, microalbuminuria and smoking. Others are unmodifiable, such as diabetes duration and family history. Among the etiological factors, subclinical endothelial dysfunction represents one of the earliest key players of atherosclerosis and it can be detected during early ages in patients with diabetes. A better assessment of cardiovascular risk in pediatric population still represents a challenge for clinicians, and thus further efforts are required to properly identify and treat pediatric patients who may suffer from cardiovascular disease later in early adulthood.

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“…While Cre-negative diabetic mice showed an increase in plasma 12(S)-HETE levels under diabetic conditions that was comparable to the increase seen in diabetic WT mice (361. 3 Targeting the TRPV1 TRP box ameliorates diabetes-induced vascular pathology. Based on the findings reported above, we hypothesized that abrogation of 12(S)-HpETE-mediated TRPV1 activation can reduce high-glucose-induced mitochondrial dysfunction in endothelial cells and protect against vascular pathology in diabetes.…”

Section: (S)-hete Is a Mediator Of Diabetes-induced Endothelial Dysmentioning

confidence: 99%

“…These comorbidities are almost exclusively attributable to vascular disease that is initiated by diabetes-induced loss of endothelial integrity. In children who -apart from hyperglycemia -do not exhibit any additional cardiovascular risk factors, the endothelium loses its ability to regulate vasotonus already a few years after disease onset (3). Endothelial dysfunction correlates to vascular disease progression and severity that are relevant to the outcome of patients with diabetes (4).…”

Section: Introductionmentioning

confidence: 99%

12(S)-HETE mediates diabetes-induced endothelial dysfunction by activating intracellular endothelial cell TRPV1

Otto

Bucher

Liu

et al. 2020

Journal of Clinical Investigation

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Endothelial dysfunction in children with type 1 diabetes mellitus

Abstract: Our findings suggest that endothelial dysfunction may be already present in children with 5 years or more elapsed since diagnosis, even in the absence of atherosclerotic structural changes. The decreased vasodilation response correlated with hyperglycemia.

Cited by 18 publications

References 30 publications

Serum Apelin: A New Marker of Early Atherosclerosis in Children with Type 1 Diabetes Mellitus

Serum Apelin: A New Marker of Early Atherosclerosis in Children with Type 1 Diabetes Mellitus

The Impact of Diabetes Mellitus on Cardiovascular Risk Onset in Children and Adolescents

12(S)-HETE mediates diabetes-induced endothelial dysfunction by activating intracellular endothelial cell TRPV1

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