Dyslipidemia in young patients with type 1 diabetes mellitus

Abstract

Objective: The association between type 1 diabetes mellitus (T1D) and dyslipidemia (DLP) increases the risk of cardiovascular disease (CVD). The aim of this study was to evaluate the presence of dyslipidemia in young T1D patients. Materials and methods: The study design was cross-sectional and descriptive. We reviewed medical records of T1D patients followed at an endocrinology service, from 1998-2012. Data collected: gender, actual age and age at diagnosis, duration of T1D since diagnosis, body mass index (BMI), pubertal stage, glycemic control (GC) determined by glycated hemoglobin (HbA1c), total cholesterol (TC), HDL, LDL, triglycerides (TG). To analyze lipid profile and metabolic control, we used the Brazilian Society of Diabetes Guidelines. Results: Were included 239 T1D patients, 136 (56.9%) females; mean ± SD: actual age 15.7 ± 5.0 years and at T1D diagnosis 7.3 ± 3.9; T1D duration 10.6 ± 6.4 years, 86.6% puberty, 15.1% overweight. The prevalence of DLP was 72.5%, 63.3% females, 86.6% puberty, mean ± SD: actual age 15.4 ± 4.8 years and at T1D diagnosis 7.2 ± 4.1 years, duration of T1D 10.7 ± 6.1 years. We found high-CT in 56.7%, low-HDL = 21.7%, high LDL = 44.0%, high-TG = 11.8%. Between females with DLP, 83.5% was in puberty. We find correlation between the presence of DLP, a poor GC and BMC. Conclusion: We found a high prevalence of DLP in young patients with T1D, particularly in puberty females. Programs targeting the prevention of dyslipidemia should be adopted, especially for this group, in order to prevent/delay chronic complications and cardiovascular disease. Arch Endocrinol Metab. 2015;59(3):215-9

Audit of the dietetic care of patients with type 1 diabetes at a large Australian paediatric tertiary hospital and comparison with the International Society for Paediatric and Adolescent Diabetes nutrition guidelines

“…In our cohort, 23% of all patients were dyslipidaemic, and this is consistent with dyslipidaemia rates of 22–29% in children with diabetes found in Germany . Much higher rates of 72.5% were found in a cohort of adolescents and young adults in Brazil . Dietary intervention for dyslipidaemia includes improving glycaemic control, weight reduction (if indicated) and decreasing saturated fat intake as recommended by the American Diabetes Association .…”

Obesity and dyslipidemia – An urgent matter in youth from the general population and in type 1 diabetic patients

“…also found that dyslipidemia was more common in adolescents than younger children (15), what would be expected based on previous studies (17,18). Females were particularly affected.…”

“…In another paper featured in this issue of Archives of Endocrinology and Metabolism, Homma and cols. found that 15.1% of children with T1D are overweight or obese (15), which is lower than previously reported nationwide in the BrazDiab (16). They also verified that dyslipidemia is common in this population, reaching 72.5% of their study group.…”

Evaluation of lipid profile among children and adolescents with type 1 diabetes mellitus in Bangladesh

“…8 The prevalence of DLP in the general population, including children, has recently increased. 9 DLP in DM patients is likely to play an important role in the development of atherogenesis.…”