Comparison between doubled haploid lines and lines obtained via the bulk method in tobacco

Lemos, Roxane do Carmo; Pádua, José Maria Villela; Bruzi, Adriano Teodoro; Oliveira, Vando Braz de; Ramalho, Magno Antônio Patto

doi:10.1590/1984-70332022v22n4a44

Cited by 1 publication

(1 citation statement)

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“…Tobacco ( Nicotiana spp. ), a series of seventy-six naturally occurring species belonging to the Solanaceae family is cultivated around the world [ 1 , 2 ]. Several Nicotiana species are used for curing types of diseases and for recreation as they serve as a reservoir of a wide range of secondary metabolites viz.…”

Section: Introductionmentioning

confidence: 99%

Current Status and De Novo Synthesis of Anti-Tumor Alkaloids in Nicotiana

Habib

Islam

et al. 2023

Metabolites

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Alkaloids are the most diversified nitrogen-containing secondary metabolites, having antioxidant and antimicrobial properties, and are extensively used in pharmaceuticals to treat different types of cancer. Nicotiana serves as a reservoir of anti-cancer alkaloids and is also used as a model plant for the de novo synthesis of various anti-cancer molecules through genetic engineering. Up to 4% of the total dry weight of Nicotiana was found to be composed of alkaloids, where nicotine, nornicotine, anatabine, and anabasine are reported as the dominant alkaloids. Additionally, among the alkaloids present in Nicotiana, β-carboline (Harmane and Norharmane) and Kynurenines are found to show anti-tumor effects, especially in the cases of colon and breast cancers. Creating new or shunting of existing biosynthesis pathways in different species of Nicotiana resulted in de novo or increased synthesis of different anti-tumor molecules or their derivatives or precursors including Taxadiane (~22.5 µg/g), Artemisinin (~120 μg/g), Parthenolide (~2.05 ng/g), Costunolide (~60 ng/g), Etoposide (~1 mg/g), Crocin (~400 µg/g), Catharanthine (~60 ng/g), Tabersonine (~10 ng/g), Strictosidine (~0.23 mg/g), etc. Enriching the precursor pool, especially Dimethylallyl Diphosphate (DMAPP), down-regulating other bi-product pathways, compartmentalization or metabolic shunting, or organelle-specific reconstitution of the precursor pool, might trigger the enhanced accumulation of the targeted anti-cancer alkaloid in Nicotiana.

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Section: Introductionmentioning

confidence: 99%