Factors Associated to Quality of Life in Children and Adolescents With Cystic Fibrosis

Abstract

<jats:p>ABSTRACT Objective: To verify the association between quality of life, functional capacity and clinical and nutritional status in children and adolescents with cystic fibrosis (CF). Methods: Cross-sectional study, including patients from eight to 18 years old with CF. Quality of life, functional capacity, nutritional status and clinical status were evaluated with the Cystic Fibrosis Questionnaire; the 6-minute walk test (6MWT) and manual gripping force (MGF); the height percentiles for age and body mass index for age and respiratory function test, respectively. Pearson and Spearman correlation tests and logistic regression were used to analyze the data. Results: A total of 45 patients, 13.4±0.5 years old, 60% female, 60% colonized by Pseudomonas aeruginosa and 57.8% with at least one F508del mutation participated in the study. When assessing the perception of quality of life, the weight domain reached the lowest values, and the digestive domain, the highest. In the pulmonary function test, the forced expiratory volume of the first second was 77.3±3.3% and the 6MWT and MGF presented values within the normal range. There was an association between quality of life and functional capacity, nutritional status and clinical status of CF patients. Conclusions: The study participants had good clinical conditions and satisfactory values of functional capacity and quality of life. The findings reinforce that the assessment of quality of life may be important for clinical practice in the management of treatment.</jats:p>

Polish Cystic Fibrosis Patients’ Health-Related Quality of Life and Its Influencing Factors: A Cross-Sectional, Single-Centre Study

“…The positive correlation of the physical functioning domain with FEV1% is well documented in many research papers [ 26 , 29 , 35 , 36 , 37 , 40 , 43 , 44 ]. Similar to our results, FEV1% positively correlated with treatment burden in studies by Santana et al [ 45 ], Gancz et al [ 29 ] and Quittner et al [ 35 ]. Body image and weight were also correlated with FEV1% in that study and others [ 28 , 36 , 37 ].…”

Mental Health of Cystic Fibrosis Patients and the COVID-19 Pandemic in Poland: A Single-Center Comparative Study

“…Similar to our study, there was no statistically significant correlation with FEV1%. However, BMI was negatively correlated with the emotional functioning domain (r = −0.31, p ≤ 0.05) [ 47 ]. In the French study, adults with CF had the highest median (80) in the emotional domain [ 48 ].…”

Qualidade de vida em crianças com fibrose cística: aspectos individuais e familiares

“…Chamou a atenção, inicialmente, quando da análise dos resultados, o volume expressivamente maior de artigos na literatura internacional em relação ao encontrado em periódicos nacionais. Apesar disso, percebeu-se a existência de instrumentos validados para a realidade brasileira para aferição da QVS (AIRES et al, 2011;ARAUJO et al, 2014;SANTANA et al, 2020) e QV específica para pacientes com FC (ROZOV et al, 2006;SANTOS et al, 2013, BOON et al, 2020CHENEY et al, 2020;SANTANA et al, 2020). Assim, compreendeu-se que ainda há a necessidade de desenvolvimento de mais pesquisas relacionando a FC e QV considerando as dimensões espaciais, contextuais, sociais e culturais existentes no Brasil.…”