Prevenção da formação de biofilmes em marcapassos artificiais: é viável?

Abstract

Objective: To identify the antimicrobial agents used in the prevention of biofilm formation on artificial pacemakers. Methods: Literature review, in order to answer the following question: "What antimicrobial agents are applied to prevent biofilm formation on artificial pacemakers?" The databases PubMed, Web of Science, Scopus, Science Direct, Cochrane, CINAHL, Embase, and LILACS were used in all languages and without time restriction. Results: The final sample consisted of five primary studies, mostly experimental laboratory ones. The investigations identified agents with promising potential for reduction or inhibition of biofilm formation on pacemakers. An association between physical-chemical agents and pharmacological antimicrobials was highlighted. Conclusion: Prevention of biofilm formation on pacemakers is feasible. Among the agents that stood out were rifampicin, AIGIS ® , aqueous neobactrim formulation, and a plasma coating using a combination of trimethylsilane and oxygen for coating deposition. ResumoObjetivo: Identificar os agentes antimicrobianos utilizados na prevenção da formação de biofilme em marcapassos artificiais. Métodos: Revisão da literatura para responder a seguinte questão: "Quais agentes antimicrobianos são usados para prevenir a formação de biofilmes em marcapassos artificiais?" As bases de dados PubMed, Web of Science, Scopus, Science Direct, Cochrane, CINAHL, Embas e e LILACS foram consultadas em todos os idiomas sem restrição de tempo. Resultados: A amostra final apresentou cinco estudos primários, sendo a maioria experimental. As investigações identificaram agentes com potencial para a redução ou inibição da formação de biofilmes em marcapassos. Destacou-se a associação de agentes físico-químicos e farmacológicos aos agentes antimicrobianos. Conclusão: A prevenção da formação de biofilmes em marcapassos é viável. Os agentes mais promissores para obter este efeito foram a rifampicina, AIGIS ® , a formulação aquosa neobactrim e a cobertura com trimetilsilano e oxigênio em superfícies tratadas com plasma.

Biofilms formation and prevention on urinary catheters: a bibliometric analysis

“…Finally, the third strategy is the disintegration of the biofilm matrix, through the use of substances capable of destroying its physical integrity and consequent loss of the protective barrier and exposure of microbial cells to antimicrobials. These findings are in agreement with more recent studies on biofilm prevention and formation, reinforcing the originality of the findings (SOUSA et al, 2017a;GÜRTLER et al, 2019).…”

Late postoperative complications in surgical patients: an integrative review

“…Even if the intention was to compare interventions, there were no clinical studies published in the databases to support this approach. In addition, the different approaches used limit comparisons between studies and countries (38) .…”

The impact of biofilm formation on implantable cardiac devices

“…Biofilm can be defined as a community of conjugated microorganisms, with reduced metabolism, which adhere to biotic or abiotic surfaces and secrete an extracellular matrix that surrounds them (Henriques et al, 2013). This layer is made up of extracellular polymeric substances (EPS), like polysaccharides, carbohydrates, proteins, and nucleic acids; it has a liquid aspect, giving the culture a higher antimicrobial resistance, protecting them against mechanical forces (Henriques et al, 2013;Sousa et al, 2017).…”

“…It acts as a continuous contamination and infection source when compared to planktonic bacteria (Henriques et al, 2013). The following factors contribute to the difficulty in controlling and eliminating this type of culture: morphological aggregation properties, immune system evasion mechanisms, and resistancegene transfer between members of the microbiota (Henriques et al, 2013;Sousa et al, 2017). A planktonic bacteria can be released from a mature biofilm and colonize other surfaces.…”