Valores de referência para exames laboratoriais de hemograma da população adulta brasileira: Pesquisa Nacional de Saúde

Rosenfeld, Luiz Gastão; Malta, Déborah Carvalho; Szwarcwald, Célia Landmann; Bacal, Nydia Strachman; Cuder, Maria Alice Martins; Pereira, Cimar Azeredo; Figueiredo, André William; Silva, Alanna Gomes da; Machado, Ísis Eloah; Silva, Wanessa Almeida da; Neto, Giácomo Balbinotto; Júnior, Jarbas Barbosa da Silva

doi:10.1590/1980-549720190003.supl.2

Cited by 16 publications

(6 citation statements)

References 22 publications

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“…The data from the medical records were recorded in an Excel spreadsheet. The variables were the tests that preceded extubation: PaO 2 with normal values between 80 and 100 mmHg, PaCO 2 between 35 and 45 mmHg, hemoglobin with normal values between 12.5 and 16.5 g/dL in men and 11.5 and 15.5 in women 24 .…”

Section: Methodsmentioning

confidence: 99%

Factors associated with extubation failure in an intensive care unit: a case-control study

Arcanjo

Beccária

2023

Rev. Latino-Am. Enfermagem

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Objective: to investigate the factors associated with extubation failure of patients in the intensive care unit. Method: unpaired, longitudinal, retrospective and quantitative case-control with the participation of 480 patients through clinical parameters for ventilator weaning. Data were analyzed by: Fisher’s exact test or the chi-square test; unpaired two-tailed Student’s t test; and Mann-Whitney test. Significant P values lower than or equal to 0.05 were admitted. Results: of the patients, 415 (86.5%) were successful and 65 (13.5%) failed. Success group: the most negative fluid balance, APACHE II in 20 (14-25), weak cough in 58 (13.9%). Failure group: the most positive fluid balance, APACHE II in 23 (19-29), weak cough in 31 (47.7%), abundant amount of pulmonary secretions in 47.7%. Conclusion: positive fluid balance and the presence of inefficient cough or inability to clear the airway were predictors of extubation failure.

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Section: Methodsmentioning

confidence: 99%

Factors associated with extubation failure in an intensive care unit: a case-control study

Arcanjo

Beccária

2023

Rev. Latino-Am. Enfermagem

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“…The values of the hematological components were determined according to the methods and parameters proposed by the clinical analysis laboratories during the period in which the samples were collected. However, considering the recent results of the National Health Survey (PNS) in Brazil for average values of laboratory blood tests 9 , the parameters considered low in the exams of the patients in the sample remain below the average of the Brazilian population.…”

Section: Methodsmentioning

confidence: 99%

Hematotoxicity and functional impacts related to chemotherapy with doxorubicin and cyclophosphamide for invasive ductal breast carcinoma: a study in clinical records

et al. 2021

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Objective: To evaluate the occurrence of hematological and functional toxicities during chemotherapy with doxorubicin and cyclophosphamide in women with breast invasive ductal carcinoma. Methods: This was a descriptive, cross-sectional and quantitative study, involving the data collection in clinical records of 119 women undergoing chemotherapy for breast invasive ductal carcinoma in an oncology outpatient clinic, carried out between February 2014 and February 2015. Results: The investigated toxicities and their respectively occurrences in patients exposed to doxorubicin and cyclophosphamide were hemoglobinemia (26,5%), leukopenia (21,6%), neutropenia (10,8%), thrombocytopenia (none) and reduced hematocrit (28,4%), in addition to fatigue (93,1%), fever (20,6%), gain (35,3%) and weight loss (22,5%). In these variables, there were no significant differences between the exposed and not exposed patients. The association with taxanes showed a significant reduction in hematocrit values (p=0.019) and the toxicities distributed by age group were not significant within the exposed group. Conclusions: Exposure to doxorubicin and cyclophosphamide was not associated with an increase in the occurrence of hematotoxicities and functional impacts in women with breast ductal invasive carcinoma, except when associated with taxane agents.

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“… Bold values are significant at p < 0.05 or have marginal significance ( p < 0.10). Reference values: Previous treatment performed with interferon and/or ribavirin; F1: mild fibrosis; F2: moderate fibrosis; F3: advanced fibrosis; F4: cirrhosis; BMI (body mass index, kg/m 2 ); Normal: 18.5–25, overweight: 25–30, obese > 30; AST (U/L) 5–40: normal, >40: high; ALT (U/L) 7–56: normal, >56: high; GGT (U/L) male 8–61: normal, >61: elevated, female 5–36: normal, >36 elevated; BT (mg/dL) up to 1.2 L: normal; albumin (g/dL) 3.5–4.7: normal, <3.5: low, >4.7 high; total cholesterol (mg/dL), up to 190 normal; >190, high [ 25 , 26 ]. SD, standard deviation; LDL, low-density lipoprotein; HDL, high-density lipoprotein; AST, aspartate aminotransferase; ALT, alanine aminotransferase; GGT, gamma-glutamyltransferase; AFP, alpha fetoprotein; HCC, hepatocellular carcinoma.…”

Section: Figurementioning

confidence: 99%

“… Reference values: Previous treatment performed with interferon and/or ribavirin; F1: mild fibrosis; F2: moderate fibrosis; F3: advanced fibrosis; F4: cirrhosis; BMI (body mass index); Normal: 18.5–25, overweight: 25–30, obesity >30; AST (U/L)—5–40: normal, >40: high; ALT (U/L) 7–56: normal, >56: high; GGT (U/L) male 8–61: normal, >61: elevated, female 5–36: normal, >36 elevated; BT (mg/dL) up to 1.2 L: normal; albumin (g/dL) 3.5–4.7: normal, <3.5: low, >4.7: high; total cholesterol (mg/dL), up to 190 normal; >190, high [ 25 , 26 ]. …”

Section: Figurementioning

confidence: 99%

Before Direct-Acting Antivirals for Hepatitis C Virus: Evaluation of Core Protein R70Q and L/C91M Substitutions in Chronically Infected Brazilian Patients Unresponsive to IFN and/or RBV

Campos

Almeida²,

Santana³

et al. 2023

Viruses

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Although chronic hepatitis C has been effectively treated with direct-acting antivirals (DAAs), the use of conventional therapy with peg-interferon (Peg-IFN) or (predominantly) ribavirin (RBV), remains widespread. R70Q/H and L/C91M amino acid substitutions in the hepatitis C virus (HCV) core protein may modulate responses to IFN and/or RBV, and are associated with cirrhosis, hepatocellular carcinoma (HCC), insulin resistance, and liver steatosis. We evaluated the R70Q/H and L/C91M substitutions, clinical and epidemiological profiles, and risk factors of Brazilian patients chronically infected with HCV subgenotypes 1a and 1b (HCV-GT1a and HCV-GT1b) unresponsive to IFN and/or RBV therapy. Sequencing and pyrosequencing analyses and sociodemographic and clinical predictive variables were used to assess the relationship between R70Q/H and L/C91M substitutions. Leukocyte counts, ALT levels, and ALT/AST ratios were significantly reduced in treated individuals, but more of these patients had advanced fibrosis and cirrhosis. L91M was more prevalent (19.7%), occurring only in HCV-GT1b, followed by R70Q/P (11.5%) and R70P (1.4%). R70Q/P exhibited higher mean AST, ALT, and GGT values, whereas L91M showed higher mean GGT values. Pyrosequencing of the L91M position revealed mutant subpopulations in 43.75% of samples.

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Valores de referência para exames laboratoriais de hemograma da população adulta brasileira: Pesquisa Nacional de Saúde

Cited by 16 publications

References 22 publications

Factors associated with extubation failure in an intensive care unit: a case-control study

Factors associated with extubation failure in an intensive care unit: a case-control study

Hematotoxicity and functional impacts related to chemotherapy with doxorubicin and cyclophosphamide for invasive ductal breast carcinoma: a study in clinical records

Before Direct-Acting Antivirals for Hepatitis C Virus: Evaluation of Core Protein R70Q and L/C91M Substitutions in Chronically Infected Brazilian Patients Unresponsive to IFN and/or RBV

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