Coated Surface on Ti-30Ta Alloy for Biomedical Application: Mechanical and in-vitro Characterization

Abstract

Several studies have been carried out to develop new materials for biomedical applications. Material surfaces that present biomimetic morphology like nanotubes or nanofibers that provides nanoscale architectures have been shown to alter cell/biomaterial interactions. The coated surface biomaterial with biocompatible polymers and nanotubes of TiO 2 is an alternative to improve osseointegration. The anodization process was performed to obtain nanotubes of TiO 2 covering the Ti-30Ta alloy surface and the electrospinning process has been used for producing polymer fibers. Characterization techniques such as scanning electron microscopy (SEM-FEG), X-ray diffraction analysis (X-rays), thermogravimetric analysis (TGA), Differential Scanning Calorimetry (DSC) and contact angle were used for samples analyses. Adult human adipose-derived stem cells (ADSCs) were used to investigate the cellular response and S. aureus antimicrobial activity on these coated surfaces. The results indicated that both surface modification treatment showed a favorable micro-environment for cells growth and proliferation such as adhesion, viability and morphology which is a desire property for an implant. In addition, the antimicrobial activity study presented both materials with similar growth of S. aureus. So, it can conclude nanotubes and nanofibers can be used at biomedical field and both present similar cell evaluation and antimicrobial activity results.

Nanostructured Surfaces to Promote Osteoblast Proliferation and Minimize Bacterial Adhesion on Titanium

“…In addition, titanium with nanotubes promoted cell proliferation on osteoblasts after seven days. Capelatto et al [ 19 ] verified that titanium nanotube samples presented a significant effect on the number of cells present, showing an increase of cells from day 1 to day 7. The cell proliferation assay results showed that titanium nanotubes (100 nm) could promote high cell proliferation compared with control Ti [ 29 ].…”

“…In recent years, the effectiveness of using TiO 2 nanotube-containing surfaces to increase cell proliferation has been demonstrated [ 11 , 19 ]. Titania nanotubes (TNTs) with a diameter of 100 nm were able to decrease Staphylococcus aureus attachment and simultaneously improve the mesenchymal stem cell response [ 20 ].…”