Improving biocompatibility for next generation of metallic implants

Bandyopadhyay, Amit; Mitra, Indranath; Goodman, Stuart B.; Kumar, M. Saravana; Bose, Susmita

doi:10.1016/j.pmatsci.2022.101053

Cited by 94 publications

(42 citation statements)

References 343 publications

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“…As a result, bone healing can be greatly enhanced by improving the attachment and differentiation of osteoblast cells [ 55 , 56 , 57 , 58 ]. Accordingly, Amit et al and other researchers evaluated the levels of osseointegration during in vivo healing and bone regeneration using a combination of biocompatible materials such as Ti-based materials, laser-grooved surfaces, and RGD coating alloys [ 59 , 60 ]. Therefore, new RGD-based materials or alloys modified with RGD peptide and phosphoserine can be developed to enhance osteogenesis and promote bone TE.…”

Section: Applications Of Rgd-based Materialsmentioning

confidence: 99%

Design of Functional RGD Peptide-Based Biomaterials for Tissue Engineering

et al. 2023

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Tissue engineering (TE) is a rapidly expanding field aimed at restoring or replacing damaged tissues. In spite of significant advancements, the implementation of TE technologies requires the development of novel, highly biocompatible three-dimensional tissue structures. In this regard, the use of peptide self-assembly is an effective method for developing various tissue structures and surface functionalities. Specifically, the arginine–glycine–aspartic acid (RGD) family of peptides is known to be the most prominent ligand for extracellular integrin receptors. Due to their specific expression patterns in various human tissues and their tight association with various pathophysiological conditions, RGD peptides are suitable targets for tissue regeneration and treatment as well as organ replacement. Therefore, RGD-based ligands have been widely used in biomedical research. This review article summarizes the progress made in the application of RGD for tissue and organ development. Furthermore, we examine the effect of RGD peptide structure and sequence on the efficacy of TE in clinical and preclinical studies. Additionally, we outline the recent advancement in the use of RGD functionalized biomaterials for the regeneration of various tissues, including corneal repair, artificial neovascularization, and bone TE.

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Section: Applications Of Rgd-based Materialsmentioning

confidence: 99%

Design of Functional RGD Peptide-Based Biomaterials for Tissue Engineering

et al. 2023

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“…At the same time, AM aids in producing implants mimicking the patient’s bone shape and size, reducing potential post-surgical complications . Over a decade after realizing its potential, AM is heavily employed in metal implant manufacturing worldwide. ,− …”

Section: Introductionmentioning

confidence: 99%

Additively Manufactured SiO₂ and Cu-Added Ti Implants for Synergistic Enhancement of Bone Formation and Antibacterial Efficacy

Ciliveri,

Bandyopadhyay

2024

ACS Appl. Mater. Interfaces

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Commercially pure titanium (CpTi), a bioinert metal, is used as an implant material at low load-bearing sites and as a porous coating on Ti6Al4V at high load-bearing sites. There is an unmet need for metallic biomaterials to improve osseointegration and inherent antimicrobial resistance. In this study, we have added 1 wt % SiO 2 and 3 wt % Cu to the CpTi matrix and processed via metal additive manufacturing (AM). Si 4+ ions promote angiogenesis and osteogenesis. CpTi-SiO 2 composition exhibited 4.5 times higher bone formation at the bone−implant interface over CpTi in an in vivo study with a rat distal femur model. In vitro bacterial studies with Gram-positive Staphylococcus aureus bacterium revealed 85% antibacterial efficacy by CpTi-SiO 2 -3Cu than CpTi. CpTi-SiO 2 -3Cu did not show any inflammatory markers in vivo, indicating the absence of cytotoxicity, but displayed delayed osseointegration compared to CpTi-SiO 2 . CpTi-SiO 2 -3Cu displayed 3-fold higher mineralized bone formation than CpTi. Our results emphasize the synergistic effect of SiO 2 and Cu addition in CpTi, promoting enhanced early stage osseointegration and inherent antibacterial efficacy, contributing toward implant longevity and stability in vivo.

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“…These problems coupled with low-strength, high cyclic fatigue, insufficient osteointegration and poor biocompatibility limit their long-term performance [13][14][15]. Thus, development of high quality and much safer biomaterials with acceptable biomechanical properties and relative ease of fabrication is receiving an increasing attention by both academics and industries.…”

Section: Introductionmentioning

confidence: 99%

Laser-based additive manufacturing of bulk metallic glasses: recent advances and future perspectives for biomedical applications

Aliyu

Panwisawas

Shinjo

et al. 2023

Journal of Materials Research and Technology

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Improving biocompatibility for next generation of metallic implants

Cited by 94 publications

References 343 publications

Design of Functional RGD Peptide-Based Biomaterials for Tissue Engineering

Design of Functional RGD Peptide-Based Biomaterials for Tissue Engineering

Additively Manufactured SiO₂ and Cu-Added Ti Implants for Synergistic Enhancement of Bone Formation and Antibacterial Efficacy

Laser-based additive manufacturing of bulk metallic glasses: recent advances and future perspectives for biomedical applications

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Improving biocompatibility for next generation of metallic implants

Cited by 94 publications

References 343 publications

Design of Functional RGD Peptide-Based Biomaterials for Tissue Engineering

Design of Functional RGD Peptide-Based Biomaterials for Tissue Engineering

Additively Manufactured SiO2 and Cu-Added Ti Implants for Synergistic Enhancement of Bone Formation and Antibacterial Efficacy

Laser-based additive manufacturing of bulk metallic glasses: recent advances and future perspectives for biomedical applications

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Product

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Additively Manufactured SiO₂ and Cu-Added Ti Implants for Synergistic Enhancement of Bone Formation and Antibacterial Efficacy