Preparation, Characterization and Biological Studies of Β-TCP and Β-TCP/Al2O3 Scaffolds Obtained by Gel-Casting of Foams

Siqueira, Lilian de; Paula, Cynthia Guimarães de; Motisuke, Mariana; Gouveia, Rubia F.; Camargo, Samira Esteves Afonso; Milhan, Noala Vicensoto Moreira; Trichês, Eliandra de Sousa

doi:10.1590/1980-5373-mr-2016-0467

Cited by 10 publications

(3 citation statements)

References 50 publications

(69 reference statements)

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“…Gas foaming can be combined with sintering to prepare glass/ceramic dual-porosity scaffolds [187,[202][203][204][205][206][207][208][209][210][211][212] in two ways: 1) Sol-gel foaming, where a foaming step is added during the sol-gel synthesis of glass to create a macroporous glass scaffold, and the resulting scaffold is later subjected to sintering to create micropores. [211] 2) Gel-cast foaming, where a foaming agent is added to a slurry of glass or ceramic powder, is then combined with organic monomers along with dispersants and binders.…”

Section: Gas Foaming and Sinteringmentioning

confidence: 99%

Glass, Ceramic, Polymeric, and Composite Scaffolds with Multiscale Porosity for Bone Tissue Engineering

Jeyachandran

Cerruti

2023

Adv Eng Mater

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Porosity affects performance of scaffolds for bone tissue engineering both in vitro and in vivo. Macropores (i.e., pores with a diameter >100 μm) are essential for cellular infiltration; micropores (i.e., pores with a diameter of 1–10 μm) promote cell adhesion and facilitate nutrient absorption. Scaffolds containing both macropores and micropores exploit the advantages of both pore sizes and have excellent osteogenic properties. Nanopores (i.e., pores with a diameter of 1–50 nm) can be included as well, to improve cell–material interactions by further enhancing the surface area of the scaffold. This article reviews fabrication techniques and properties of scaffolds with multiscale porosity, focusing on glass, ceramic, polymeric, and composite scaffolds. After discussing the structure of bone and how it inspired scaffolds for bone tissue engineering, pore nomenclature is introduced. Then, the techniques used to induce multiscale porosity, the nature of the pores created, and the effects of scaffold porosity on mechanical properties and biological activity of the scaffolds are discussed. The review concludes by providing an outlook for this field, including advancements that are made possible by computational modeling and artificial intelligence.

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Section: Gas Foaming and Sinteringmentioning

confidence: 99%

Glass, Ceramic, Polymeric, and Composite Scaffolds with Multiscale Porosity for Bone Tissue Engineering

Jeyachandran

Cerruti

2023

Adv Eng Mater

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“…It has recently been demonstrated that the development of nanosized structures and the addition of reinforcement phases can improve the mechanical properties of HAp samples [2][3][4][5][6][7][8][9][10].Several new fabrication techniques such as 3D printing [11], reaction of spherical tricalcium phosphate granules [12], gel casting [7], direct hydrothermal techniques [9] and coating techniques such as MOCVD [13] were proposed in literature for production of porous HAp.…”

Section: Introductionmentioning

confidence: 99%

Production, characterization and properties of open-cell calcium phosphate foams reinforced with alumina

et al. 2019

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In this study, tailored made open-cell calcium phosphate foams reinforced with alumina were fabricated by employing a dissolution-sintering process, using crystalline raw cane sugar as a water-leachable material. The effect of the alumina addition in the 3D morphology and in the microstructure of the produced calcium phosphate-based foams was examined. Preliminary in vitro bio-dissolution studies were performed to obtain an initial indication for the suitability of these composite bioceramic foams as implant materials. The mechanical properties of the produced composite calcium phosphate foams were also evaluated. It was found that the addition of small amount of alumina (5 wt%) resulted in a microstructural alteration affecting both the 3D geometry of the produced bioceramic foams and the morphology of the precipitated apatite during the biodegradation tests. The addition of alumina resulted in considerable enhancement of the mechanical strength of the bioceramic foam when the porosity was above 70%. The produced calcium phosphatebased composite foams (with alumina reinforcement) are suitable for biomedical applications.

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“…Nas últimas décadas, diversos métodos vêm sendo estudados para a produção de scaffolds a fim de se garantir as propriedades físicas e mecânicas desejadas. Os métodos mais utilizados são: método da réplica [8][9][10]; incorporação de materiais orgânicos que se volatilizam durante a queima [11,12]; método de gelcasting e emulsão [13][14][15][16][17][18]; prototipagem rápida e impressão 3D (3DP) [19][20][21]; e freeze casting [11,[22][23][24][25][26][27]. Dentre esses destaca-se o método de freeze casting que consiste no congelamento de uma suspensão cerâmica líquida (aquosa ou não).…”

Section: Introductionunclassified

Preparação e caracterização de scaffolds de β-fosfato tricálcico pelo método de freeze casting

Paula

Trichês

2018

Cerâmica

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Resumo Scaffolds são substratos tridimensionais que permitem a diferenciação, proliferação e crescimento celular. A fim de se atingir propriedades como biocompatibilidade, adequada porosidade e interconectividade, ideais taxas de degradação e propriedades mecânicas, este estudo teve como objetivo a produção de scaffolds de β-fosfato tricálcico (β-TCP) pelo método de freeze casting. Por meio da variação do teor de sólidos da suspensão cerâmica foi possível avaliar sua influência na microestrutura e propriedades físicas e mecânicas dos scaffolds de β-TCP. A porosidade variou entre 85 e 55% para teores de sólidos de 10 e 30 vol%, respectivamente. A morfologia dos poros foi caracterizada por um padrão lamelar, semelhante ao formato dos cristais de gelo. O aumento do teor de sólidos na suspensão cerâmica resultou na redução do número de poros lamelares. Os valores de resistência mecânica à compressão variaram entre 0,10 e 0,71 MPa. Os scaffolds com maior valor de resistência à compressão foram submetidos ao ensaio de degradação, cujos resultados revelaram que a perda de massa dos scaffolds aumentou com tempo de imersão. O maior valor de perda de massa foi de 2,89±0,64% para período de 28 dias. Os scaffolds de β-TCP apresentam grande potencial para uso na engenharia tecidual.

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Preparation, Characterization and Biological Studies of Β-TCP and Β-TCP/Al2O3 Scaffolds Obtained by Gel-Casting of Foams

Cited by 10 publications

References 50 publications

Glass, Ceramic, Polymeric, and Composite Scaffolds with Multiscale Porosity for Bone Tissue Engineering

Glass, Ceramic, Polymeric, and Composite Scaffolds with Multiscale Porosity for Bone Tissue Engineering

Production, characterization and properties of open-cell calcium phosphate foams reinforced with alumina

Preparação e caracterização de scaffolds de β-fosfato tricálcico pelo método de freeze casting

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