Hyaluronic acid accelerates bone repair in human dental sockets: a randomized triple-blind clinical trial

Abstract

This study evaluated the effects of hyaluronic acid (HA) on bone repair of human dental sockets. Thirty-two lower first premolars were extracted from 16 patients (2 per patient) for orthodontic reasons. Following the extractions, one socket was randomly filled with 1% HA gel, while the other was allowed to naturally fill with blood clot. After 30 and 90 days of surgery, patients underwent cone beam computed tomography. Five central orthoradial slices were captured from each socket. The gray intensity was measured in each image and results were reported as mean percentage of bone formation. The buccolingual alveolar ridge width was measured and dimensional changes were compared between the postoperative intervals. The pattern of alveolar trabecular bone was evaluated through the fractal dimension. Treated sockets showed a higher percentage of bone formation and fractal dimension values (58.17% and 1.098, respectively) compared with controls (48.97% and 1.074, respectively) in the 30-day postoperative period (p < 0.05). After 90 days, there was no significant difference between groups. Additionally, no significant difference was found between groups regarding the alveolar dimensions (p > 0.05). Use of 1% HA gel after tooth extraction accelerates bone repair in human dental sockets.

Evaluation of the effect of hyaluronic acid and chitosan biocomposite natural polymers in alveolar ridge preservation: an experimental study in dogs

“…9,10 ELkarargy 2013, demonstrated that biphasic calcium phosphate (HA/βTCP) scaffold with HLA provides more osteoconductive property when compared to samples without HLA. 5 The bone density and new bone formation measurements of Hyaluronic acid /biphasic calcium phosphate (HLA/HA-βTCP) treated samples was higher by 1.7 and 1.78 times respectively, than that of the HLA free samples at 2 weeks. 10,12 In an animal study, Sasaki et al (1995) concluded the osteoinductive action of HLA at 2 weeks by accelerating new bone formation of rat femur through stimulating undifferentiated mesenchymal cells (UMC).…”

“…In the field of oral surgery, it demonstrated anti-inflammatory, antioxidant, antibacterial properties, and offers a beneficial effect after wisdom tooth extraction surgery and meniscus repair. [5][6][7][8][9] It is widely used for bone tissue engineering with excellent viscoelasticity, water solubility and osteogenetic properties. 10,11 Subsequently, HLA treatment can save the amount of bone graft used and offers ease of use.…”

“…10 HLA-based materials were applied into bone defects alone or in association to scaffolds in experimental animals. 5 Osteoconductive scaffold mixed with HLA can improve the rate of bone formation by enhancing osteogenic cell adhesion, proliferation, and migration. 9,10 ELkarargy 2013, demonstrated that biphasic calcium phosphate (HA/βTCP) scaffold with HLA provides more osteoconductive property when compared to samples without HLA.…”

“…13 Moreover, Yazan et al demonstrated HLA bone induction by stimulating (UMC) around dental implant in rabbit's mandibular molar area. 5,14 HLA levels are dramatically elevated immediately after tooth extraction. It aids both soft tissue and bone healing.…”

The separation of microscale HA in aqueous solution by foam separation technique

“…Hyaluronic acid (HA) is an advanced acid straightlinked mucopolysaccharide composed of d-glucuronic acid and n-acetylglucosamine, which has important applications in health care products, cosmetics and clinical medicine [1][2][3] . At present, the main production mode of HA is microbial fermentation, and the separation and purifi cation of hyaluronic acid from fermentation liquor mainly includes quaternary ammonium salt method, chloroform method, ion exchange chromatography, ethanol precipitation method, and mass dilution membrane fi ltration method, etc 4-6 .…”