Effects of stress hormones on the production of volatile sulfur compounds by periodontopathogenic bacteria

Calil, Caroline Morini; Oliveira, Gisele Mattos; Cogo, Karina; Pereira, Antônio Carlos; Marcondes, Fernanda Klein; Groppo, Francisco Carlos

doi:10.1590/1807-3107bor-2014.vol28.0008

Cited by 22 publications

(18 citation statements)

References 28 publications

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“…Moreover, cortisol, noradrenaline, and adrenaline were able to reduce the growth of F . nucleatum and Porphyromonas endodontalis , while increasing the production of H 2 S by these bacteria [19]. These studies corroborate our findings, showing that VSCs levels could be altered even when bacterial loads are not altered.…”

Section: Discussionsupporting

confidence: 89%

Changes in salivary microbiota increase volatile sulfur compounds production in healthy male subjects with academic-related chronic stress

Nani¹,

Lima²,

Marcondes³

et al. 2017

PLoS ONE

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ObjectiveTo investigate the associations among salivary bacteria, oral emanations of volatile sulfur compounds, and academic-related chronic stress in healthy male subjects.Materials and methodsSeventy-eight healthy male undergraduate dental students were classified as stressed or not by evaluation of burnout, a syndrome attributed to academic-related chronic stress. This evaluation was carried out using the Maslach Burnout Inventory—Student Survey questionnaire. Oral emanations of hydrogen sulfide, methyl mercaptan, and dimethyl sulfide were measured using an Oral Chroma™ portable gas chromatograph. The amounts in saliva of total bacteria and seven bacteria associated with halitosis were quantified by qPCR. The in vitro production of H2S by S. moorei and/or F. nucleatum was also measured with the Oral Chroma™ instrument.ResultsThe stressed students group showed increased oral emanations of hydrogen sulfide and dimethyl sulfide, together with higher salivary Solobacterium moorei levels (p < 0.05, Mann Whitney test). There were moderate positive correlations between the following pairs of variables: Fusobacterium nucleatum and S. moorei; F. nucleatum and hydrogen sulfide; Tannerella forsythia and F. nucleatum; T. forsythia and S. moorei. These correlations only occurred for the stressed group (p < 0.05, Spearman correlation). The in vitro experiment demonstrated that S. moorei increased H2S production by F. nucleatum (p < 0.05, ANOVA and Tukey’s test).ConclusionThe increased amount of S. moorei in saliva, and its coexistence with F. nucleatum and T. forsythia, seemed to be responsible for increased oral hydrogen sulfide in the healthy male stressed subjects.

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Section: Discussionsupporting

confidence: 89%

Changes in salivary microbiota increase volatile sulfur compounds production in healthy male subjects with academic-related chronic stress

Nani¹,

Lima²,

Marcondes³

et al. 2017

PLoS ONE

Self Cite

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“…Though it has been known for a long time that hormones had some effect on the metabolism of 151 bacteria 7,[25][26][27] , the mechanisms by which this cross-talk happens to remain mostly unknown. As we 152 deepen our understanding of the precise roles of the microbiome in health and disease, we expect that 153 new mechanisms will be shown to involve host hormones, including novel interactions.…”

Section: ): 129mentioning

confidence: 99%

The effect of the stress hormone cortisol on the metatranscriptome of the oral microbiome

Duran-Pinedo

Solbiati

Frias-Lopez

2018

Preprint

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“…Halitosis can also be affected by the general hygiene of the body (i.e., dehydration, starvation, and high physical exertion), advanced age, bleeding gums, decreased brushing frequency, but also by stress [3,[13][14][15][16]. Produced during stress, catecholamines and cortisol increased hydrogen sulfide production by sub-gingival anaerobic bacteria [17]. The medications which can cause extra-oral halitosis were categorized into 10 groups: acid reducers, aminothiols, anticholinergics, antidepressants, antifungals, antihistamines and steroids, antispasmodics, chemotherapeutic agents, dietary supplements, and organosulfur substances [18].…”

Section: Introductionmentioning

confidence: 99%

The Role of Oral Microbiota in Intra-Oral Halitosis

Hampelska

Jaworska

Babalska

et al. 2020

JCM

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Halitosis is a common ailment concerning 15% to 60% of the human population. Halitosis can be divided into extra-oral halitosis (EOH) and intra-oral halitosis (IOH). The IOH is formed by volatile compounds, which are produced mainly by anaerobic bacteria. To these odorous substances belong volatile sulfur compounds (VSCs), aromatic compounds, amines, short-chain fatty or organic acids, alcohols, aliphatic compounds, aldehydes, and ketones. The most important VSCs are hydrogen sulfide, dimethyl sulfide, dimethyl disulfide, and methyl mercaptan. VSCs can be toxic for human cells even at low concentrations. The oral bacteria most related to halitosis are Actinomyces spp., Bacteroides spp., Dialister spp., Eubacterium spp., Fusobacterium spp., Leptotrichia spp., Peptostreptococcus spp., Porphyromonas spp., Prevotella spp., Selenomonas spp., Solobacterium spp., Tannerella forsythia, and Veillonella spp. Most bacteria that cause halitosis are responsible for periodontitis, but they can also affect the development of oral and digestive tract cancers. Malodorous agents responsible for carcinogenesis are hydrogen sulfide and acetaldehyde.

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Effects of stress hormones on the production of volatile sulfur compounds by periodontopathogenic bacteria

Cited by 22 publications

References 28 publications

Changes in salivary microbiota increase volatile sulfur compounds production in healthy male subjects with academic-related chronic stress

Changes in salivary microbiota increase volatile sulfur compounds production in healthy male subjects with academic-related chronic stress

The effect of the stress hormone cortisol on the metatranscriptome of the oral microbiome

The Role of Oral Microbiota in Intra-Oral Halitosis

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