The effect of the stress hormone cortisol on the metatranscriptome of the oral microbiome

Duran-Pinedo, Ana E.; Solbiati, José O.; Frias-Lopez, Jorge

doi:10.1101/339325

Cited by 10 publications

(14 citation statements)

References 32 publications

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“…[109][110][111] It was recently suggested that oral microorganisms can directly respond to the presence of stress hormones, a field termed "microbial endocrinology". 112 gression. 10,113 Further studies aimed at understanding the effects of stress on the oral microbiome are warranted.…”

Section: Stressmentioning

confidence: 99%

“…In the late 1990s, reports identified that stress associated with financial strain and inadequate coping behaviors was significantly associated with increased severity of periodontal disease 109‐111 . It was recently suggested that oral microorganisms can directly respond to the presence of stress hormones, a field termed “microbial endocrinology” 112 . Recent functional analysis of the effect of the stress‐related hormone cortisol on oral microorganisms (metatranscriptomics) identified that members of the phylum Fusobacteria become more active in the presence of cortisol 112 .…”

Section: Pregnancymentioning

confidence: 99%

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Impact of systemic factors in shaping the periodontal microbiome

Teles

Wang

Hajishengallis

et al. 2020

Periodontology 2000

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Since 2010, next‐generation sequencing platforms have laid the foundation to an exciting phase of discovery in oral microbiology as it relates to oral and systemic health and disease. Next‐generation sequencing has allowed large‐scale oral microbial surveys, based on informative marker genes, such as 16S ribosomal RNA, community gene inventories (metagenomics), and functional analyses (metatranscriptomics), to be undertaken. More specifically, the availability of next‐generation sequencing has also paved the way for studying, in greater depth and breadth, the effect of systemic factors on the periodontal microbiome. It was natural to investigate systemic diseases, such as diabetes, in such studies, along with systemic conditions or states, , pregnancy, menopause, stress, rheumatoid arthritis, and systemic lupus erythematosus. In addition, in recent years, the relevance of systemic “variables” (ie, factors that are not necessarily diseases or conditions, but may modulate the periodontal microbiome) has been explored in detail. These include ethnicity and genetics. In the present manuscript, we describe and elaborate on the new and confirmatory findings unveiled by next‐generation sequencing as it pertains to systemic factors that may shape the periodontal microbiome. We also explore the systemic and mechanistic basis for such modulation and highlight the importance of those relationships in the management and treatment of patients.

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Section: Stressmentioning

confidence: 99%

Section: Pregnancymentioning

confidence: 99%

Impact of systemic factors in shaping the periodontal microbiome

Teles

Wang

Hajishengallis

et al. 2020

Periodontology 2000

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“…Accordingly, the impact of cortisol on the community-wide transcriptome of the oral microbiome has been recently investigated and shifts in the gene expression profiles of the oral microbiota have been reported in a similar manner to those observed in vivo during periodontitis. 99 The authors found that pure cultures of F.…”

Section: Psycholog I C Al S Tre Ss and Periodontal Microb Iomementioning

confidence: 99%

Environmental factors and periodontal microbiome

Buduneli

2020

Periodontology 2000

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Periodontal diseases are chronic inflammatory, multifactorial diseases where the major triggering factors for disease onset are bacteria and their toxins, but the major part of tissue destruction occurs as a result of host response towards the periodontal microbiome. Periodontal microbiome consists of a wide range of microorganisms including obligate and facultative anaerobes. In health, there is a dynamic balance between the host, environment, and the microbiome. Environmental factors, mainly tobacco smoking and psychological stress, disrupt the symbiotic relationship. Tobacco smoke and its components alter the bacterial surface and functions such as growth. Psychological stressors and stress hormones may affect the outcome of an infection by changing the virulence factors and/or host response. This review aims to provide currently available data on the effects of the major environmental factors on the periodontal microbiome.

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“…Indeed, a significant enhancement for P. micra growth and an inhibitory effect for A. actinomycetemcomitans and some bacteria of the red and orange complexes were described [ 18 , 52 ]. A recent study based on a metatranscriptomic approach showed that glucocorticoids can directly induce changes in gene expression profiles of the oral microbiome, similar to those observed in periodontitis patients [ 53 ]. Moreover, patients suffering from periodontitis with a high-stress level exhibited a significant correlation between cortisol levels and T. forsythia detection compared to patients with low-stress levels or stress-managed patients.…”

Section: Discussionmentioning

confidence: 94%

Relations of Psychosocial Factors and Cortisol with Periodontal and Bacterial Parameters: A Prospective Clinical Study in 30 Patients with Periodontitis Before and After Non-Surgical Treatment

Dubar

Clerc‐Urmès²,

Baumann³

et al. 2020

IJERPH

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(1) Background: The progression of periodontitis, induced by polymicrobial dysbiosis, can be modified by systemic or environmental factors such as stress or anxiety affecting host response. The purpose of this study is to evaluate the potential associations between psychosocial factors scores or salivary cortisol levels with clinical periodontal parameters and bacterial environment in patients with periodontitis; (2) Methods: Subgingival microbiota was collected in two pathological and one healthy sites from thirty diseased patients (before/after scaling and root planing (SRP)) and from one healthy site from thirty control patients. Usual clinical periodontal parameters were recorded, and a saliva sample was harvested. Patients completed stress and anxiety self-assessment questionnaires. Cortisol concentrations were determined by ELISA and bacteria were identified by PCR; (3) Results: No correlation between salivary cortisol and the stress-anxiety self-declared was found (p > 0.05), but high concentrations of this molecule were associated positively and linearly with periodontal pocket depth (p = 0.04). It appeared that certain psychosocial stressors are associated with a modulation of the bacterial colonization of pockets of diseased group (before/after SRP), notably concerning Tannerella forsythia (p = 0.02), Porphyromonas gingivalis (p = 0.03), Fusobacterium nucleatum (p = 0.049) and Campylobacter rectus (p = 0.01). (4) Conclusion: This study reveals associations between bacteria colonization and psychosocial parameters in periodontitis that needs to be further investigated.

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The effect of the stress hormone cortisol on the metatranscriptome of the oral microbiome

Abstract: 15

Cited by 10 publications

References 32 publications

Impact of systemic factors in shaping the periodontal microbiome

Impact of systemic factors in shaping the periodontal microbiome

Environmental factors and periodontal microbiome

Relations of Psychosocial Factors and Cortisol with Periodontal and Bacterial Parameters: A Prospective Clinical Study in 30 Patients with Periodontitis Before and After Non-Surgical Treatment

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