Prevalence of Hashimoto's thyroiditis in psoriasis patients

Abstract

OBJECTIVE:To study the prevalence of Hashimoto's Thyroiditis in a sample of psoriasis patients.METHODS: Cross-sectional observational study of 120 individuals (60 with psoriasis and 60 control subjects) paired by gender and age for thyroid function (thyroid stimulating hormone, free T4), antithyroperoxidase and antithyroglobulin tests and physical examination. Psoriasis Area and Severity Index and Nail Psoriasis Severity Index were evaluated simultaneously. Epidemiological, clinical and treatment data was collected from medical records. Patients with documented hypothyroidism and/or goiter associated with positive antithyroperoxidase antibody were considered to have Hashimoto's Thyroiditis. RESULTS:The prevalence of Hashimoto's Thyroiditis in the group with psoriasis was 21.6%; in the control group, it was 4/60 (6.6%) with p=0. 03 (OR=3.8;). In the group of patients with psoriasis, Hashimoto's Thyroiditis was more common in women (p=0.002) and less common in those who had polyarticular arthropathic psoriasis (p=0.05) and plaque psoriasis (p=0.005). A logistic regression showed that the only independent variable associated with Hashimoto's thyroiditis was plaque psoriasis.CONCLUSIONS: There is a high prevalence of Hashimoto's Thyroiditis in psoriatic patients, especially in women. Hashimoto's Thyroiditis is less common in patients with the plaque form of psoriasis.

Prevalence of autoimmune thyroid disease in patients with psoriasis: a meta-analysis

“…After screening the titles and abstracts, the remaining 42 studies underwent further full-text screening. Eventually, 11 studies8–16 21 22 that met the inclusion criteria were included in the final analysis (figure 1).…”

“…However, the study reported by Tsai et al 9 pointed that the association between psoriasis and AITD was limited. In recent years, several observational studies regarding the association between psoriasis and AITD were published in succession, but the results of the studies were inconsistent 10–16. In addition, Karadag et al reported that the commonly administered acitretin treatment for psoriasis system treatment affects the levels of free T4 (thyroid hormone) 17.…”