Prevalence of autoimmune thyroid disease in patients with psoriasis: a meta-analysis

Abstract

ObjectivePsoriasis is a chronic inflammatory disease with autoimmune aetiology. A possible link between psoriasis and autoimmune thyroid disease (AITD) has been suggested in some studies with inconsistent findings. This meta-analysis aims to determine the association between psoriasis and AITD.DesignA meta-analysis of observational studies.Data sourcesPubMed, EMBASE, Scopus and the Cochrane Library were searched up to 1 November 2021.Eligibility criteria for selecting studiesWe included non-randomised studies, each with over 50 cases in every group, focusing on the rate of comorbidity between psoriasis and AITD.Data extraction and synthesisTwo independent reviewers screened the articles and extracted data. The restricted maximum-likelihood was applied to perform the meta-analysis. OR and 95% CIs were pooled to compare the prevalence of AITD in psoriasis and control groups. Heterogeneity was assessed with I2 statistic. The Newcastle-Ottawa Scale and Agency for Healthcare Research and Quality were applied for quality assessment. The risk of bias was assessed with Risk Of Bias In Non-randomised Studies-of Interventions (ROBINS-I).ResultsEleven available studies with data on 253 313 patients with psoriasis and 1 376 533 controls were included. Meta-analysis showed that patients with psoriasis had a higher prevalence of AITD (OR 1.76, 95% CI 1.35 to 2.28, Z=4.25, p<0.01), especially loss-of-function disorder of the thyroid gland. Both thyroglobulin antibodies positive rate (OR 1.98, 95% CI 1.27 to 3.10, Z=3.00, p<0.01) and thyroid peroxidase antibodies positive rate (OR 2.15, 95% CI 1.31 to 3.52, Z=3.05, p<0.01) were also increased in the psoriasis group compared with the control group.ConclusionsOur study indicates that the rate of co-occurring AITD was significantly increased in patients with psoriasis. It suggests that the increased risk of AITD should be concerned in patients with psoriasis.PROSPERO registration numberCRD42020206005.

Knowledge Mapping and Research Hotspots of Comorbidities in Psoriasis: A Bibliometric Analysis from 2004 to 2022

“…Patients with psoriasis have been reported to suffer from a higher frequency of autoimmune diseases (#6), such as uveitis [ 60 ], inflammatory bowel disease [ 61 ], multiple sclerosis [ 62 ], Hashimoto’s thyroiditis [ 63 ], bullous pemphigoid [ 64 ], vitiligo [ 65 ], and alopecia areata [ 66 ]. The association between them is exerted through intricate immunopathological pathways and mechanisms, which have not yet been fully elucidated [ 67 ].…”

Risk of cancer in Korean patients with psoriatic arthritis: a nationwide population-based cohort study

“…Such an incidence rate may have contributed to the distinct difference between patients with PsA and controls without PsA. In patients with PsO and PsA, few studies exist on the association with thyroid cancer compared with the evidence for association with autoimmune thyroid disorders 29–33. Future research will be necessary on the association between PsO, PsA and thyroid cancer and whether autoimmune thyroid disorders are involved in this association.…”