Association between Hemogram Parameters and Coronary Collateral Development in Subjects with Non-ST-Elevation Myocardial Infarction

Abstract

SUMMARY OBJECTIVE Coronary collateral development (CCD) predicts the severity of coronary heart disease. Hemogram parameters, such as mean platelet volume (MPV), eosinophil, red cell distribution width, and platelet distribution width (PDW), are supposed novel inflammatory markers. We aimed to compare hemogram parameter values in patients presenting with non-ST-elevation myocardial infarction (NSTEMI) with adequate or inadequate CCD. METHODS A total of 177 patients with NSTEMI undergoing coronary arteriography were enrolled and divided into two groups based on the development of CCD: one group with adequate CCD (n=88) and the other with impaired CCD (n=89). RESULTS Baseline demographics and clinical risk factors were similar between the groups. Hemogram parameters were not significantly different between the two groups. However, compared to the inadequate CCD group, the median PDW was significantly higher in the adequate CCD group, 17.6 (1.4) vs. 17.8 (1.6) p=0.004. In a multivariate analysis, PDW (p=0.001, 95% CI for OR: 0.489(0,319-0,750) was found to be significantly different in the adequate CCD group compared to the inadequate CCD group. Pearson’s correlation analysis revealed that PDW was significantly correlated with the Rentrop score (r=0.26, p<0.001). CONCLUSIONS We suggest that since PDW is an index that is inexpensive and easy to assess, it could serve as a marker of CCD in patients with NSTEMI.

White blood cells and platelet profiles of diabetic patients at University of Gondar specialized referral hospital: A comparative cross‐sectional study

“…Similarly, no significant association was found between MPV and type-II DM, 39 myocardial infarction patients, 40 and acute coronary syndrome. 41 In the present study, WBC indices (WBC count, lymphocyte, and mixed number) increased significantly in the DM patients compared with the control group.…”

Predictive value of red blood cell distribution width in septic shock patients with thrombocytopenia: A retrospective study using machine learning

“…High oxidative stress leading to elevated RDW through increasing the destruction of normal RBCs and the release of large premature RBCs into the circulation can be observed in sepsis 48 . Although RDW will increase in the status of inflammation and oxidative stress as mentioned above, it is also elevated in some non‐inflammatory diseases, such as acute coronary syndromes among elderly patients, anemia in postmenopausal women, and non‐ST‐elevation myocardial infarction 49‐51 . We infer that only combined with other indicators can take maximum advantage of RDW.…”

“… 48 Although RDW will increase in the status of inflammation and oxidative stress as mentioned above, it is also elevated in some non‐inflammatory diseases, such as acute coronary syndromes among elderly patients, anemia in postmenopausal women, and non‐ST‐elevation myocardial infarction. 49 , 50 , 51 We infer that only combined with other indicators can take maximum advantage of RDW.…”

The Association Between Red Blood Cell Distribution Width and the Severity of Diabetic Chronic Kidney Disease

“…Increased RDW values have also been reported in end-stage renal disease (ESRD) patients of hemodialysis, 20 which indicated the association between RDW and renal functions. However, there have been some contrary reports to note that RDW was not associated with inflammatory conditions such as 21 and vitamin D deficiency, 22 because accompanied diseases, such as iron deficiency anemia, might also affect RDW values as well as, which caused an enhance in RDW. Therefore, our conclusion needs to be confirmed by more related studies.…”