Determination of Ochratoxin A Levels in Mixed Feed and Feed Stuffs Used in Some Laying Hens and Ruminant Enterprises of Sivas City

Gümüş, Recep; Ercan, Nazlı; İmik, Halit

doi:10.1590/1806-9061-2017-0674

Cited by 13 publications

(9 citation statements)

References 26 publications

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“…OTA is also found in feed and feedstuffs. A study showed that OTA in mixed feed and feedstuffs used in some laying hens was found to be positive in 64 of the 89 samples analyzed ( Gumus et al., 2018 ). In another study from South America published by Magnoli et al.…”

Section: Otamentioning

confidence: 99%

Ochratoxin A: its impact on poultry gut health and microbiota, an overview

et al. 2021

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Ochratoxin A ( OTA ) is a widespread mycotoxin, that has strong thermal stability, and is difficult to remove from feed. OTA is nephrotoxic, hepatotoxic, teratogenic, immunotoxic, and enterotoxic to several species of animals. The gut is the first defense barrier against various types of mycotoxins present in feed that enter the body, and it is closely connected to other tissues through enterohepatic circulation. Compared with mammals, poultry is more sensitive to OTA and has a lower absorption rate. Therefore, the gut is an important target tissue for OTA in poultry. This review comprehensively discusses the role of OTA in gut health and the gut microbiota of poultry, focusing on the effect of OTA on digestive and absorptive processes, intestinal barrier integrity, intestinal histomorphology, gut immunity, and gut microbiota. According to the studies described to date, OTA can affect gut dysbiosis, including increasing gut permeability, immunity, and bacterial translocation, and can eventually lead to gut and other organ injury. Although there are many studies investigating the effects of OTA on the gut health of poultry, further studies are needed to better characterize the underlying mechanisms of action and develop preventative or therapeutic interventions for mycotoxicosis in poultry.

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Section: Otamentioning

confidence: 99%

Ochratoxin A: its impact on poultry gut health and microbiota, an overview

et al. 2021

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“…Chemical name for Ochratoxin A contains 7-carboxy-5-chloro-8-hydroxy-4,4-dihydro-3(R)-methyl isocoumarin (Ochratoxin α; OTα) that is linked through the 7-carboxy group to l-β-phenylalanine by a peptide bond. Briefly, the chemical abstract number, molecular formula and molecular mass of each Ochratoxins type is described in table 1 [10]. On the other hand in acidic and alkaline solution Ochratoxin A shows different properties.…”

Section: Ochratoxin Amentioning

confidence: 99%

“…Ochratoxin A is one of the secondary metabolite of mycotoxin group and can be existed in several agricultural products and in animal feeds [10]. Number of studies finding report indicate that Ochratoxin A was existed in several processed and unprocessed food stuffs, species and different alcoholic beverage.…”

Section: Occurrence Of Ochratoxin a In Food And Feedsmentioning

confidence: 99%

A Review of Ochratoxin A Occurrence, Condition for the Formation and Determination Methods

Atumo¹

2020

JDDMC

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“…Three yeast cell wall-based mycotoxin adsorbent products were tested, which were classified as yeast cell wall (YCW), yeast cell wall extract (YCWE), and a postbiotic yeast cell wall-based blend (PYCW). Four mycotoxins—deoxynivalenol (DON), beauvericin (BEA), ochratoxin A (OTA), and citrinin (CIT)—were selected for their significance based on public concern, their occurrence in ruminant feed or feedstuff [ 1 , 34 , 35 , 36 , 37 , 38 ], their known toxic effects [ 23 , 39 , 40 , 41 ], and their agri-economic significance [ 2 , 42 ]. The present study not only sheds light on the potential multi-mycotoxin interaction capacity of the tested binder products, especially for novel adsorbent compositions such as PYCW, but also provides insight into BEA and CIT mitigation, which has not been widely studied.…”

Section: Introductionmentioning

confidence: 99%

Comparative Assessment of Different Yeast Cell Wall-Based Mycotoxin Adsorbents Using a Model- and Bioassay-Based In Vitro Approach

Yiannikouris

Shandilya

et al. 2023

Toxins

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Frequently reported occurrences of deoxynivalenol (DON), beauvericin (BEA), and, to a lesser extent, ochratoxin A (OTA) and citrinin (CIT) in ruminant feed or feedstuff could represent a significant concern regarding feed safety, animal health, and productivity. Inclusion of yeast cell wall-based mycotoxin adsorbents in animal feeds has been a common strategy to mitigate adverse effects of mycotoxins. In the present study, an in vitro approach combining adsorption isotherm models and bioassays was designed to assess the efficacy of yeast cell wall (YCW), yeast cell wall extract (YCWE), and a postbiotic yeast cell wall-based blend (PYCW) products at the inclusion rate of 0.5% (w/v) (ratio of adsorbent mass to buffer solution volume). The Hill’s adsorption isotherm model was found to best describe the adsorption processes of DON, BEA, and CIT. Calculated binding potential for YCW and YCWE using the Hill’s model exhibited the same ranking for mycotoxin adsorption, indicating that BEA had the highest adsorption rate, followed by DON and CIT, which was the least adsorbed. PYCW had the highest binding potential for BEA compared with YCW and YCWE. In contrast, the Freundlich isotherm model presented a good fit for OTA adsorption by all adsorbents and CIT adsorption by PYCW. Results indicated that YCW was the most efficacious for sequestering OTA, whereas YCWE was the least efficacious. PYCW showed greater efficacy at adsorbing OTA than CIT. All adsorbents exhibited high adsorption efficacy for BEA, with an overall percentage average of bound mycotoxin exceeding 60%, whereas moderate efficacies for the other mycotoxins were observed (up to 37%). Differences in adsorbent efficacy of each adsorbent significantly varied according to experimental concentrations tested for each given mycotoxin (p < 0.05). The cell viability results from the bioassay using a bovine mammary epithelial cell line (MAC-T) indicated that all tested adsorbents could potentially mitigate mycotoxin-related damage to bovine mammary epithelium. Results from our studies suggested that all tested adsorbents had the capacity to adsorb selected mycotoxins in vitro, which could support their use to mitigate their effects in vivo.

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Determination of Ochratoxin A Levels in Mixed Feed and Feed Stuffs Used in Some Laying Hens and Ruminant Enterprises of Sivas City

Cited by 13 publications

References 26 publications

Ochratoxin A: its impact on poultry gut health and microbiota, an overview

Ochratoxin A: its impact on poultry gut health and microbiota, an overview

A Review of Ochratoxin A Occurrence, Condition for the Formation and Determination Methods

Comparative Assessment of Different Yeast Cell Wall-Based Mycotoxin Adsorbents Using a Model- and Bioassay-Based In Vitro Approach

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