São Paulo School of Advanced Sciences on Vaccines: an overview

Bioinformática como ferramenta na análise de epitopos antigênicos no design de vacinas contra Anaplasma marginale, Leishmania spp., SARS-Cov-2 e toxina de Clostridium septicum / Bioinformatics as a tool in the analysis of antigenic epitopes in the design of vaccines against Anaplasma marginale, Leishmania spp., SARS-Cov-2, and Clostridium septicum toxin

“…Os anticorpos exibem várias funções, tais como; neutralizar a entrada de patógenos na célula hospedeira, opsonização de antígenos e, consequentemente, estimulam a fagocitose, ativação do sistema complemento e/ou Brazilian Journal of Development, Curitiba, v.7, n.4, p. 41634-41650 apr 2021 provocar citotoxicidade na célula alvo. Antígenos capazes de induzir resposta humoral protetora satisfatória são alvos tanto na vacinologia convencional quanto na reversa (SORGI et al, 2020). As sequências proteicas com maiores escores para prováveis antígenos protetores obtidos estão listados na Tabela 2).…”

Immune System Modulation by the Adjuvants Poly (I:C) and Montanide ISA 720

“…Vaccination is undoubtedly among the public health interventions that have mainly contributed to preventing several life-threatening or disabling diseases caused by infectious agents ( 2 ). In the specific case of vaccines against protozoan parasites, such as Plasmodium spp, several factors hampered the development of effective formulations, like the complex life cycle of the parasites, antigenic variability, and poor immunogenicity of potentially protective antigens ( 3 ). In this sense, alternative adjuvants could be the key to obtaining effective vaccine formulations ( 4 ).…”