Iron supplementation for lambs experimentally infected by Haemonchus contortus: response to anemia and iron store in the bone marrow

Casanova, Valeska Paula; Aires, Adelina Rodrigues; Collet, Silvana Giacomini; Krause, Alexandre; Moresco, Rafael Noal; Bochi, Guilherme Vargas; Silva, Aleksandro S.; Leal, Marta L.R.

doi:10.1590/1678-5150-pvb-5490

Cited by 8 publications

(5 citation statements)

References 18 publications

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“…The significantly lower serum Zn and Fe levels of the infected lambs relative to the control suggest a disturbance in their metabolism caused by H. contortus . Both mixtures had high iron contents, so differences between unsupplemented infected lambs and infected lambs supplemented with a herbal mixture could influence the serum Fe status during treatment [58]. Some medicinal herbs from central Europe containing essential microelements have been reported to possess antioxidant capacity which is correlated with the content of total phenolic compounds [59].…”

Section: Discussionmentioning

confidence: 99%

Natural chemotherapeutic alternatives for controlling of haemonchosis in sheep

et al. 2019

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Background Parallel in vitro and in vivo experiments were designed to evaluate promising chemotherapeutic alternatives for controlling haemonchosis in ruminants. In vitro anthelmintic activities (egg hatch test – EHT; larval development test – LDT) of aqueous and methanolic herbal extracts Mix1 and Mix2 were investigated. The in vivo effects of dietary supplementation with Mix1 and Mix2 on the parasitological status, inflammatory response, antioxidant parameters and microbial community of the lambs infected experimentally with Haemonchus contortus were investigated . Lambs were divided into four groups for the in vivo study: uninfected control lambs (C), infected lambs (I), infected lambs supplemented with Mix1 (I + Mix1) and infected lambs supplemented with Mix2 (I + Mix2). The experimental period was 70 days. Results The number of eggs per gram (EPG) of feces was quantified 22, 30, 37, 44, 51, 58, 65 and 70 days post-infection, and mean abomasal worm counts were assessed 70 days post-infection. Quantitative analyses identified 57.3 and 22.2 mg/g phenolic acids, 41.5 and 29.5 mg/g flavonoids and 1.4 and 1.33 mg/g protoberberine-type alkaloids in Mix1 and Mix2, respectively. The methanolic extracts of the herbal mixtures in both in vitro tests had higher anthelmintic effects ( P < 0.01) than the aqueous extracts, but the effects did not differ significantly between Mix1 and Mix2 ( P > 0.05). I + Mix1 and I + Mix2 lowered mean EPGs between 44 and 70 d by 58.1 and 51.6%, respectively. The level of IgG antibodies against H. contortus increased significantly after infection in each infected group. Conclusion These results represent the first monitoring of the in vitro anthelmintic effects of herbal mixtures on H. contortus . The in vivo experiment indicated that the anthelmintic effect was not sufficient for the elimination of parasites, but this herbal treatment may affect the host over a longer term, reducing the parasitic infection in the host.

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Section: Discussionmentioning

confidence: 99%

Natural chemotherapeutic alternatives for controlling of haemonchosis in sheep

et al. 2019

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“…An increase in red blood cells had been previously reported in iron supplemented lambs (Casanova et al, 2018). This probably occurs since iron is an important component of nonenzymatic metalloproteins such as hemoglobin, ferredoxin and ferritin.…”

Section: Discussionmentioning

confidence: 71%

“…These consist of vitamin and mineral supplements which improve coagulation and stimulate erythropoiesis. This has a positive impact on blood cell counts, and on the sheep's energetic recovery (MOTTIN et al, 2019;CASANOVA et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Vitamin and mineral supplementation improves erythrocytic recovery and productive performance of infected by gastrointestinal parasites

Farias

Cardoso

Feijó

et al. 2021

Rev. bras. saúde prod. anim.

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The objective of the present study was to evaluate the effect of a vitamin and mineral complex, associated with the application of an efficient anthelmintic, in parasitized lambs, with characteristic signs of gastrointestinal nematode infection, on hematological clinical parameters of clinical improvementand weight gain. 60 lambs Australian Merino breed, with 8 and 9 months of age, were segregated in four groups: control (no supplemetation); formula 1 (Iron Dextran, Organic Phosphorus, Cyanocobalamin and Vitamin k); formula 2 (Iron Dextran, Organic Phosphorus and Cyanocobalamin); and formula 3 (Vitamin k). Hematocrit, prothrombin time, total plasma proteins, color of the conjunctiva and weight gain were analyzed. The results were submitted to analysis of variance (ANOVA) through the repeated measures test. There was no statistical difference between treatments for the variables of hematocrit (P = 0.564), prothrombin time (P = 0.911) and plasma proteins (P = 0.6), for the conjunctiva color variable there was a difference (P = 0.052 ), with greater results for the groups supplemented with Vitamin K, Butafosfan, Cyanocobalamin and Iron (groups F1 and F3), as well as those same groups reached higher body weight at D35 (P = 0.023). It can be concluded that the administration of vitamin and mineral complex, associated with efficient anthelmintic, promoted a better performance in parasitized lambs.

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“…Two of the hemograms performed showed microcytic erythrocytes, a characteristic alteration of iron deficiency. Lambs infected with H. contortus and supplemented with iron had less severe anemia than those not supplemented (Casanova et al 2018). This data may indicate that the association of supplements containing iron, minerals, amino acids, and vitamins is interesting with respect to increasing the speed of recovery of sick cattle.…”

Section: Discussionmentioning

confidence: 89%

Mortality caused by gastrointestinal nematodes in beef cattle submitted to an inadequate sanitary protocol

et al. 2022

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The aim of this study was to describe the epidemiological, clinical, and pathological findings of two outbreaks of gastrointestinal nematode infections in beef cattle kept under an inadequate sanitary protocol. An outbreak of trichostrongylosis occurred in Amambai, Mato Grosso do Sul (MS), from May to July 2016. The herd consisted of 3,000 Nellore cows, and of these, fifteen died after showing emaciation and diarrhea and remaining in recumbency. At necropsy, the abomasum showed edema in the folds, white, raised areas, multifocal to coalescent, and small ulcers. Histopathology showed larvae compatible with trichostrongylid nematodes were present inside the abomasum glands. Trichostrongylus axei was identify in the abomasum. The hemonchosis outbreak began in October 2018, in a breeding and finishing property in Santa Rita do Pardo, MS. Of 4,000 cattle aged 8 to 18 months, 673 became ill and 117 died. Clinical signs were emaciation, weakness, dehydration, submandibular edema, and soft stools. At necropsy, large numbers of nematodes were found in the abomasum; they were morphologically classified as Haemonchus placei. Both outbreaks were caused by failures in the parasite control protocol. However, in Outbreak I, frost and immune stress caused by lack of food may have contributed to the deaths. In Outbreak I, the main failure in the devermination protocol was the use of anthelmintics without carrying out an efficacy test. In Outbreak II, there was no parasite control protocol in the rearing and finishing property, and in the breeding property, there was resistance to the anthelmintic used (ivermectin). The two outbreaks highlight the importance of gastrointestinal nematode control protocols in cattle and demonstrate that infections by T. axei and H. placei can be lethal for this species.

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Iron supplementation for lambs experimentally infected by Haemonchus contortus: response to anemia and iron store in the bone marrow

Cited by 8 publications

References 18 publications

Natural chemotherapeutic alternatives for controlling of haemonchosis in sheep

Natural chemotherapeutic alternatives for controlling of haemonchosis in sheep

Vitamin and mineral supplementation improves erythrocytic recovery and productive performance of infected by gastrointestinal parasites

Mortality caused by gastrointestinal nematodes in beef cattle submitted to an inadequate sanitary protocol

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