Antioxidant activities and lutein content of 11 marigold cultivars (Tagetes spp.) grown in Thailand

Ingkasupart, Pajaree; Manochai, Benya; Song, Woo Tae; Hong, Jeong Hee

doi:10.1590/1678-457x.6663

Cited by 43 publications

(22 citation statements)

References 29 publications

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“…Generally speaking, flowers of T. erecta showed a great variability regarding the phenolic content. For example, some studies reported higher TPC values than our data [5,23] while others showed lower ones [6,24] and others found values in the same range [25]. The study carried out by Li et al deserves a particular mention [23].…”

Section: Resultsmentioning

confidence: 47%

Edible Flowers of Tagetes erecta L. as Functional Ingredients: Phenolic Composition, Antioxidant and Protective Effects on Caenorhabditis elegans

et al. 2018

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Tagetes erecta L. has long been consumed for culinary and medicinal purposes in different countries. The aim of this study was to explore the potential benefits from two cultivars of T. erecta related to its polyphenolic profile as well as antioxidant and anti-aging properties. The phenolic composition was analyzed by LC-DAD-ESI/MSn. Folin-Ciocalteu, DPPH·, and FRAP assays were performed in order to evaluate reducing antiradical properties. The neuroprotective potential was evaluated using the enzymes acetylcholinesterase and monoamine oxidase. Caenorhabditis elegans was used as an in vivo model to assess extract toxicity, antioxidant activity, delayed aging, and reduced β-amyloid toxicity. Both extracts showed similar phenolic profiles and bioactivities. The main polyphenols found were laricitin and its glycosides. No acute toxicity was detected for extracts in the C. elegans model. T. erecta flower extracts showed promising antioxidant and neuroprotective properties in the different tested models. Hence, these results may add some information supporting the possibilities of using these plants as functional foods and/or as nutraceutical ingredients.

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Section: Resultsmentioning

confidence: 47%

Edible Flowers of Tagetes erecta L. as Functional Ingredients: Phenolic Composition, Antioxidant and Protective Effects on Caenorhabditis elegans

et al. 2018

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“…Lutein is known for its antioxidant activity. 7 The cytochrome P450 enzymes are the main players in Phase I metabolism and also involved in the oxidation and elimination of a wide array of xenobiotics such as drugs and toxins. 8 A number of therapeutic agents such as quinidine, vinblastine, ergotamine, berberine, and colchicines synthetic agents such as nifedipine and diazepamare the main substrates of CYP3A4.…”

Section: Discussionmentioning

confidence: 99%

Effect of Lutein on Cytochrome P450 (Isoform CYP3A4) - An in vitro Study

Meenapriya¹,

Anitha²,

Lakshmi³

2018

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Background: Lutein is a carotenoids vitamin rich in many fruits and vegetables and also available in multivitamin products. It is consumed for its effect on eye disease, cancer, diabetes and other health conditions. Recently, herbal preparations are increasingly used in healthcare systems and concomitant administration of synthetic medications may cause pharmacokinetic or pharmacodynamic interactions leading to very serious medical problems. Understanding the ability of herbal extracts and preparations to modulate the metabolizing enzymes can help the health system for proper treatment of patients and thereby can avoid many adverse effects associated with it. The aim of the study was to find the effect of lutein isolated from Tagetes erecta L on cytochrome P450 isoform CYP3A4. Materials and Methods: The different concentrations of lutein (5-100µg/ml), potassium phosphate buffer, CYP450 reagent and substrate 7-Benzyloxy-4-trifluoromethylcoumarin (BFC) were added to a 96-well plate. The fluorescent intensities of the products were measured by Perkin Elmer Enspire fluorescence reader using an excitation and emission wavelength of 405 nm and 460 nm, respectively to examine the effect of lutein on Cytochrome P 450 isoform CYP3A4 and the IC 50 was calculated by plotting concentrations of lutein against the corresponding percent inhibition. Results: All the tested concentrations of lutein showed potent inhibition against CYP3A4 in a dose-dependent manner. The IC 50 value was found to be 35.27µg/ml. Conclusion: The inhibitory effect of lutein indicates the possibilities of herb-drug interaction if it is co-administered with prescribed drugs that are normally metabolised by CYP3A4 enzyme.

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“…65 Bunga marigold merupakan bahan baku potensial lutein, [66][67][68] dimana sebagian besar suplemen lutein yang ditemui menggunakan lutein ester dari ekstrak bunga marigold. 19,69 Proses hidrolisis basa menggunakan pelarut etanol yang mengandung kalium hidroksida dapat memutuskan ikatan antara lutein dan ester asam lemak sehingga dapat dihasilkan lutein bebas, 70 namun perlu diperhatikan bioavailabilitas dan kestabilan lutein ketika diaplikasikan pada berbagai bidang, khususnya dalam pembuatan suplemen. 67 Pemanfaatan bunga marigold varietas lokal dapat menjadi alternatif dalam mengembangkan suplemen kesehatan lutein, yang mampu bersaing dengan suplemen kesehatan lain dari luar negeri.…”

Section: Tabel 1 Peran Lutein Dalam Berbagai Bagian Dan Sel Otak 15unclassified

Telaah Literatur Potensi Lutein dari Bunga Marigold Lokal sebagai Suplemen Kesehatan

Kurniawan

Yusuf

Heriyanto

et al. 2020

mpk

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Abstract Lutein is a type of xanthophyll that accumulated predominantly in eye macula, and is distributed in several parts of the human body, such as skin and brain. Lutein accumulation in the human body is associated with the health benefits of lutein, including being an antioxidant and protecting, the eyes and skin from exposure to blue light, and playing an important role to maintain human cognitive health. Lutein cannot be synthesized by human, so consumption of lutein can be obtained from foods such as fruits and green vegetables, as well as from supplements. The purpose of writing this article was to increase awareness of the importance of adequate lutein intake early in the body, as well as increased research interest in exploring local resources as a potential source of lutein, the Mega Orange marigold from Bali as a raw material for health supplements. The potential lutein article as health supplement was prepared by reviewing articles from international journals and followed by testing the composition of carotenoids in Mega Orange marigolds and a health supplement product by HPLC analysis. Various studies and article publications regarding the health benefits of lutein have been found in the last decade. There are at least two main benefits of lutein, namely as an antioxidant and to maintain the health of organs such as the eyes, brain and skin. Meanwhile, the local marigold flower variety of Mega Orange contains carotenoids lutein and zeaxanthin up to 13.88 mg/g dry weight, and this result is in the range of lutein concentrations in marigold flowers that grow in Thailand. Mega Orange marigold is a potential source of lutein that can be used as raw materials for health supplement products. The importance of lutein intake for the human body makes the use of lutein from local marigolds in the manufacture of health supplements needs to be optimized and utilized. Abstrak Lutein termasuk jenis xantofil yang terakumulasi secara dominan pada makula, serta terdistribusi pada beberapa bagian tubuh manusia seperti kulit dan otak. Akumulasi lutein pada tubuh manusia dikaitkan dengan manfaat kesehatan lutein, diantaranya sebagai antioksidan serta melindungi mata dan kulit dari paparan sinar biru, dan memainkan peranan penting untuk menjaga kesehatan kognitif manusia. Lutein tidak dapat disintesis oleh manusia, sehingga konsumsi lutein dapat diperoleh dari makanan seperti buah dan sayuran hijau, serta dari suplemen. Tujuan penulisan artikel ini adalah untuk meningkatkan kesadaran akan pentingnya kecukupan asupan lutein sejak dini dalam tubuh, serta menambah minat penelitian akan eksplorasi sumber daya lokal yang sebagai sumber potensial lutein yaitu bunga marigold Mega Orange dari Pulau Bali sebagai bahan baku suplemen kesehatan. Artikel potensi lutein sebagai suplemen kesehatan ini disusun dengan menelaah artikel-artikel pada jurnal internasional dan diikuti dengan pengujian komposisi karotenoid pada bunga marigold Mega Orange dan satu produk suplemen kesehatan dengan analisis Kromatografi Cair Kinerja Tinggi (KCKT). Berbagai penelitian dan publikasi artikel mengenai manfaat kesehatan lutein telah banyak ditemukan dalam dekade terakhir. Setidaknya terdapat dua manfaat utama lutein, yaitu sebagai antioksidan dan untuk menjaga kesehatan organ tubuh seperti mata, kulit, dan otak. Adapun, bunga marigold lokal varietas Mega Orange mengandung karotenoid lutein dan zeaksantin hingga 13,88 mg/g berat kering, dan hasil ini berada pada rentang konsentrasi lutein dalam bunga marigold yang tumbuh di Thailand. Bunga marigold Mega Orange merupakan sumber potensial lutein yang dapat digunakan sebagai bahan baku produk suplemen kesehatan. Pentingnya asupan lutein bagi tubuh manusia menjadikan pemanfaatan lutein dari bunga marigold lokal dalam pembuatan suplemen kesehatan perlu dioptimalkan dan dimanfaatkan.

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Antioxidant activities and lutein content of 11 marigold cultivars (Tagetes spp.) grown in Thailand

Cited by 43 publications

References 29 publications

Edible Flowers of Tagetes erecta L. as Functional Ingredients: Phenolic Composition, Antioxidant and Protective Effects on Caenorhabditis elegans

Edible Flowers of Tagetes erecta L. as Functional Ingredients: Phenolic Composition, Antioxidant and Protective Effects on Caenorhabditis elegans

Effect of Lutein on Cytochrome P450 (Isoform CYP3A4) - An in vitro Study

Telaah Literatur Potensi Lutein dari Bunga Marigold Lokal sebagai Suplemen Kesehatan

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