Solvent extraction effects on phytochemical constituents profiles, antioxidant and antimicrobial activities and functional group analysis of Ecballium elaterium seeds and peels fruits

Felhi, Samir; Daoud, A.; Hajlaoui, Hafedh; Mnafgui, Kais; Gharsallah, Néji; Kadri, Adel

doi:10.1590/1678-457x.23516

Cited by 131 publications

(97 citation statements)

References 36 publications

(38 reference statements)

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“…Extract yields were found to be higher in root as comparison of leaf in both extracts. These results coincide with several previous reports [Felhi et al 2017, Tatiya et al 2011. Higher yield in water can be attributed to their high di electric constant which responsible for solubility of bioactive compounds [Adhikari, 2018].…”

Section: Biochemical Activitiessupporting

confidence: 94%

Population Status, Distribution, Antioxidant Properties and Antibacterial Activity of Threatened Herb Gentiana kurroo Royle

Lal¹,

Kumari²,

Samant³

et al. 2019

JBCC

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Sustainable utilization and conservation of the threatened species is a major challenge for conservationists. For the conservation and reintroduction of species, comprehensive information on the ecological elements, potential habitats and pharmaceutical importance of the species is essentially required. This has necessitated initiating studies on habitat and population ecology of the threatened species. In view of the above, the present study investigated populations of Gentian kurroo representing different habitats and aspects in Himachal Pradesh. Among the populations, mean density of G. kurroo 80.75 Ind per 100m 2 and range varied from 63.0-110.0 Ind 100m-2. The density showed direct relation with soil, slope, aspect and habitat. The particular geographical distribution of the species was sub tropical indicated species habitat specificity. Biological features, aspects, slope and pressure contributed to the critical population status of the G.. kurroo. The present investigation clearly showed that G.. kurroo populations occurred in fragmented pattern in the subtropical ecosystem. Species re-introduction should therefore carefully select suitable habitat with suggested setting in this study. The present study confirmed that population ecology, habitat distribution modelling provide assistance in the species recovery plan. The study would not only help in ecorestoration of the species and habitats but also in recovering the species population and improving its conservation.

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Section: Biochemical Activitiessupporting

confidence: 94%

Population Status, Distribution, Antioxidant Properties and Antibacterial Activity of Threatened Herb Gentiana kurroo Royle

Lal¹,

Kumari²,

Samant³

et al. 2019

JBCC

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“…Saponins, steroids, and anthraquinones were absent in acetone crude extract, but only alkaloids, tannins, and phenols were presented in n-hexane fraction. The capacity of methanol solvent in extracting more percent of extract yield and phytochemical constituents is in agreement with the ndings of Felhi et al [9] from Tunisia and Truong et al [43]…”

Section: Discussionsupporting

confidence: 91%

“…The augmentations of antimicrobial resistances have harmed both human and animal health, exposing to longer periods of hospitalization, and affect treatment costs [3,4,5]. Alternative medicines have been screening from a variety of plants for their pharmacological potential as secondary metabolites are less in drug adverse effects, resistances, and residues [6,7,8,9].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of in-vitro antibacterial and antifungal activities of crude extracts and solvent fractions of methanol extract of leaves of Ricinus communis Linn (Euphorbiaceae) against selected pathogens

Kebede¹

2020

Preprint

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Background Impacts of infectious diseases are reduced due to development of antimicrobial agents. However, the effectiveness of the antimicrobial agents is reduced over time because of the emergence of antimicrobial resistance.To overcome these problems scholars have been searching for alternative medicines, particularly focusing on traditionally used medicinal plants. Ricinus communis Linn is used as a traditional treatment for bovine mastitis, wound infection, and other medicinal purposes. Moreover, the antimicrobial activity of Ricinus communis Linn leaf at crude extract level has been confirmed against human originated pathogens in the previous studies. The objective of the present study was to further evaluate the antimicrobial activities of Ricinus communis Linn leaf extracts and fractions. The Ricinus communis Linn leaves were macerated in absolute methanol and acetone solvents. The methanol crude extract was shown best antimicrobial activity and exposed to further fractionation via increasing polarity of solvents (n-hexane, chloroform, ethyl acetate, and aqueous). Test microorganisms included in the study were six laboratory reference bacteria (E. coli, S. aureus, S. agalactiae, K. pneumoniae, P. aeruginosa, and S. Pyogenes), two clinical isolate bacteria (E. coli and S. aureus), and Candida albicans. The agar well diffusion method was employed to determine antimicrobial activity. The minimum inhibitory concentrations (MIC) and minimum bactericidal/fungicidal concentrations (MBC/MFC) were determined through broth microdilution method. Results The results indicated that the best antimicrobial activity(based on zone of inhibition) for ethyl acetate fraction ranging from 14.67 mm (clinical E. coli) to 20.33 mm (S. aureus) at 400mg/ml however, n-hexane exhibited lowest antimicrobial activity. Among tested fractions, ethyl acetate fraction was produced lowest MIC values ranging from 1.5625mg/ml (S. aureus) to 16.67 mg/ml (Candida albicans). The ethyl acetate fraction showed bactericidal activity against all tested microorganisms. Conclusion Methanol extract of Ricinus communis Linn leaf exhibited better antimicrobial activity than acetone extract. Hence, ethyl acetate fraction of crude methanol extract exhibited best antimicrobial activity indicating its potential for development of antimicrobial products.

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“…In addition, it is of less cost and free from ethical issues compared to ethanol [29]. The results of previous studies have also proved the efficiency of methanol in extracting the antimicrobial principle [30].…”

Section: Extraction and Phytochemical Investigationmentioning

confidence: 99%

Investigation on antimicrobial, antioxidant and cytotoxicity properties of triple bark extract formulated using traditional medicinal plants

et al. 2019

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Since ancient times, medicinal plants have been widely used against dreadful pathogens due to their ability to kill microbes. Also, the limitations of the present treatment methods have led the researchers to explore for new formulations with aspects of better wound healing and control of infections. In the present study antimicrobial, antioxidant and cytotoxicity properties of a polyherbal formulation prepared from the barks of three medicinal plants for treating wound infection were investigated. The polyherbal formulation was tested for broad spectrum antimicrobial activity against gram-positive bacteria Methicillin-Resistant Staphylococcus aureus (MRSA) and gram-negative bacteria such as Pseudomonas aeruginosa, Escherichia coli, Salmonella typhi and antifungal activity against Fluconazole resistant Candida albicans. The result reveals that the polyherbal formulation exhibited antimicrobial activity against antibiotic resistant gram-positive MRSA and C. albicans and moderate against gram-negative P. aeruginosa, E. coli and S. typhi. The antioxidant activities like 1,1′-diphenyl-2-picrylhydrazyl and hydrogen peroxide scavenging ability of the formulation was compared with standard ascorbic acid. The higher antioxidant activity was found mostly due to the presence of higher amount of phenols and flavonoids. The phenol was found to be 48.63 ± 0.35 mg/g and flavonoids was 29.52 ± 1.13 mg/g. The polyherbal formulation helps in the proliferation of fibroblast cells without affecting the viability. The above result reveals that the formulation has good antimicrobial and antioxidant activity without affecting the viability of the cell.

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Solvent extraction effects on phytochemical constituents profiles, antioxidant and antimicrobial activities and functional group analysis of Ecballium elaterium seeds and peels fruits

Cited by 131 publications

References 36 publications

Population Status, Distribution, Antioxidant Properties and Antibacterial Activity of Threatened Herb Gentiana kurroo Royle

Population Status, Distribution, Antioxidant Properties and Antibacterial Activity of Threatened Herb Gentiana kurroo Royle

Evaluation of in-vitro antibacterial and antifungal activities of crude extracts and solvent fractions of methanol extract of leaves of Ricinus communis Linn (Euphorbiaceae) against selected pathogens

Investigation on antimicrobial, antioxidant and cytotoxicity properties of triple bark extract formulated using traditional medicinal plants

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