The polyherbal-loaded polycaprolactone nanofibrous mat was prepared by electrospinning technique, and physical and chemical characteristics of nanofibrous mats were studied using scanning electron microscopy, x-ray diffraction, thermogravimetric analyzer, and Fourier transform infrared spectroscopy. The presence of various phytochemicals in the crude monoherbal and polyherbal extracts was analyzed. The antimicrobial activity and biocompatibility of the polyherbal-loaded nanofibrous mats were studied. The drug release pattern of the polyherbal-loaded nanofibrous mats was studied at different time intervals. The 5% drug-loaded nanofibrous mat shows higher sustainable drug release rate than 1% and 3% drug-loaded nanofibrous mats. The cell viability was found to be 98.91%, 98.77%, 98.5%, and 98.22% for polycaprolactone and 1%, 3%, and 5% for polyherbal-loaded nanofibrous mats, respectively.
Wound healing properties of some herbs have been known for decades. Recently, electrospun mats have been used as a wound dressing material due to the high surface area of fiber and ease of incorporation of drug into the fiber matrix. In this aspect, the incorporation of herbal extracts in electrospun matrix could provide synergistic effect for wound healing. In the present work, extracts from Cissus quadrangularis (CQ) and Galinsoga parviflora Cav (GP) were loaded into the PVA solution in different proportions. These solutions were used to produce nanofibrous mat in electrospinning and the characteristics of the mat were analyzed. The morphology of the fiber was analyzed using scanning electron microscope (SEM), the presence of functional groups was identified using Fourier transform infrared spectroscopy (FTIR). The result of drug release shows that the GP extract loaded PVA nanofibrous mat has sustained drug release of 28% after 8 h of incubation compared to CQ loaded PVA nanofibrous mat. This trend follows as the concentration of GP increases in the mixture. The antimicrobial efficiency of the prepared mat was evaluated against both Gram-negative bacteria E. coli and Gram-positive bacteria S. aureus. The prepared nanofibrous mat has shown excellent antibacterial activity, cell viability, hemocompatibility, and sufficient tensile properties which indicates that it could be a promising biomaterial for wound dressing application.
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