Characterization of polyherbal-incorporated polycaprolactone nanofibrous mat for biomedical applications

Ramamoorthy, Rajalakshmi; Andiappan, Muthumanickkam; Muthalagu, Murugesan

doi:10.1177/0883911519876065

Cited by 5 publications

(6 citation statements)

References 13 publications

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“…From the results, it could be observed that pure PVA shows low hemolytic activity compared to the herbal drug loaded PVA nanofibrous mat which is attributed to the change in the surface of the nanofibrous mat. 34 While comparing the samples, the PVA + CQ:GP(100:0) has shown low hemolytic activity than all other samples (Table 2). However, as per the ASTM standard, the ideal biomaterial should possess less than 5% hemolysis rate and could be considered as good blood compatible material.…”

Section: Blood Compatibilitymentioning

confidence: 94%

“…However, as per the ISO 10993-5 standard, the cell viability of the biomaterial should be more than 80% for non-toxic materials and could be considered as good biocompatible material. 34,37 Hence, all the herbal drug loaded nanofibrous mat samples exhibited high biocompatibility.…”

Section: Cell Viabilitymentioning

confidence: 96%

“…The rate of drug release depends on the diameter of the fiber, in such a way that the smaller diameter fibers are densely packed, which inhibits the matrix swelling and erosion of the molecules. 33,34 Generally, in aqueous media the PVA gets eroded to release the drug, 35 but the addition of GP in the PVA mat decreased the fiber diameter thereby reducing the erosion and rate of drug release (Figure 2). The drug release rate was decreased according to the following order PVA + CQ:GP(1 00:0) ˃ PVA + CQ:GP(70:30) ˃ PVA + CQ:GP(50 :50) ˃ PVA + CQ:GP(30:70) > PVA + CQ:GP(0:1 00).…”

Section: Thermal Analysis Of Nanofibersmentioning

confidence: 99%

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Synthesis, characterization, and antimicrobial properties of novel dual drug loaded electrospun mat for wound dressing applications

Andra¹,

Balu

Ramamoorthy

et al. 2021

Journal of Bioactive and Compatible Polymers

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Wound healing properties of some herbs have been known for decades. Recently, electrospun mats have been used as a wound dressing material due to the high surface area of fiber and ease of incorporation of drug into the fiber matrix. In this aspect, the incorporation of herbal extracts in electrospun matrix could provide synergistic effect for wound healing. In the present work, extracts from Cissus quadrangularis (CQ) and Galinsoga parviflora Cav (GP) were loaded into the PVA solution in different proportions. These solutions were used to produce nanofibrous mat in electrospinning and the characteristics of the mat were analyzed. The morphology of the fiber was analyzed using scanning electron microscope (SEM), the presence of functional groups was identified using Fourier transform infrared spectroscopy (FTIR). The result of drug release shows that the GP extract loaded PVA nanofibrous mat has sustained drug release of 28% after 8 h of incubation compared to CQ loaded PVA nanofibrous mat. This trend follows as the concentration of GP increases in the mixture. The antimicrobial efficiency of the prepared mat was evaluated against both Gram-negative bacteria E. coli and Gram-positive bacteria S. aureus. The prepared nanofibrous mat has shown excellent antibacterial activity, cell viability, hemocompatibility, and sufficient tensile properties which indicates that it could be a promising biomaterial for wound dressing application.

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Section: Blood Compatibilitymentioning

confidence: 94%

Section: Cell Viabilitymentioning

confidence: 96%

Section: Thermal Analysis Of Nanofibersmentioning

confidence: 99%

See 1 more Smart Citation

Synthesis, characterization, and antimicrobial properties of novel dual drug loaded electrospun mat for wound dressing applications

Andra¹,

Balu

Ramamoorthy

et al. 2021

Journal of Bioactive and Compatible Polymers

Self Cite

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“…The sample is calibrated at 50º before analysis. This process shows X-ray diffraction, which is then recorded as a diffraction pattern [16,17].…”

Section: X-ray Diffraction (Xrd) Analysismentioning

confidence: 99%

“…This software is a predictions strategies which evaluated designed inhibitors by using Lipinski's rule of five. 16 Swiss ADME software is a web/online based device used to estimate the behaviour of medicinal compounds [18].…”

Section: Pharmacokinetic Bioinorganic Compound and Admet Properties P...mentioning

confidence: 99%

Identification and Characterization of Shogaol and 6-Gingerol Complex From Madurese Herbal Medicine

et al. 2021

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Ginger (Zingiber officinale) and meniran (Phyllanthus niruri L.) is a cultural heritage in Madura ethnic, Indonesia. Madurese herbs were traditionally boiled using pottery which is made from clay. Clay consists of Silica (SiO2), Aluminum silicate (Al2O3), Magnesium (MgO), Calcium (CaO),) Iron (Fe2O3) and Potassium (K2O). This component contributes to the efficacy of traditional Madurese herbal medicine by forming bioinorganic complex compounds. The present study aimed to characterize the bioinorganic complex compounds from Madurese herbal medicine and predict their pharmacokinetics activity. Madurese traditional herbal medicine composition was determined using Liquid Chromatography-Mass Spectrometry/Mass Spectrometry (LC-MS/MS). Then, Fourier-Transform Infrared Spectroscopy (FITR), X-Ray Fluorescence (XRF), Scanning Electron Microscopy (SEM) and X-Ray Diffraction (XRD) analysis were used to determine the functional group, transition metal composition, morphology, and the crystal structure of bioinorganic complex compounds from Madurese traditional herbal medicine, respectively. The pharmacokinetic activity was predicted using ADMET software. The results showed that Fe and Mn bind to hydroxyl groups (-OH) in the 6-gingerol and shogaol compounds to form bioinorganic complex compounds. The morphological structure of Madurese herbal powder was porous slabs. The crystal structures of Madurese herbal powder were amorphous and uniform in size. The pharmacokinetic activity analysis showed that Madura traditional herbal has a high solubility in water and easily absorbed by the body. In conclusion, bioinorganic complex compounds of Madurese traditional herbal medicine can be considered as a therapeutic agent in further research.

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Development of Cissus quadrangularis-Loaded POSS-Reinforced Chitosan-Based Bilayer Sponges for Wound Healing Applications: Drug Release and In Vitro Bioactivity

Aker,

Tamburaci,

Tihminlioglu

2023

ACS Omega

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Nowadays, antibiotic-loaded biomaterials have been widely used in wound healing applications. However, the use of natural extracts has come into prominence as an alternative to these antimicrobial agents in the recent period. Among natural sources, Cissus quadrangularis (CQ) herbal extract is used for treatment of bone and skin diseases in ayurvedic medicine due to its antibacterial and anti-inflammatory effects. In this study, chitosan-based bilayer wound dressings were fabricated with electrospinning and freeze-drying techniques. CQ extract-loaded chitosan nanofibers were coated on chitosan/POSS nanocomposite sponges using an electrospinning method. The bilayer sponge is designed to treat exudate wounds while mimicking the layered structure of skin tissue. Bilayer wound dressings were investigated with regard to the morphology and physical and mechanical properties. In addition, CQ release from bilayer wound dressings and in vitro bioactivity studies were performed to determine the effect of POSS nanoparticles and CQ extract loading on NIH/3T3 and HS2 cells. The morphology of nanofibers was investigated with SEM analysis. Physical characteristics of bilayer wound dressings were determined with FT-IR analysis, swelling study, open porosity determination, and mechanical test. The antimicrobial activity of CQ extract released from bilayer sponges was investigated with a disc diffusion method. Bilayer wound dressings' in vitro bioactivity was examined using cytotoxicity determination, wound healing assay, proliferation, and the secretion of biomarkers for skin tissue regeneration. The nanofiber layer diameter was obtained in the range of 77.9−97.4 nm. The water vapor permeability of the bilayer dressing was obtained as 4021 to 4609 g/m 2 day, as it is in the ideal range for wound repair. The release of the CQ extract over 4 days reached 78−80% cumulative release. The release media were found to be antibacterial against Gramnegative and Gram-positive bacteria. In vitro studies showed that both CQ extract and POSS incorporation induced cell proliferation as well as wound healing activity and collagen deposition. As a result, CQ-loaded bilayer CHI-POSS nanocomposites were found as a potential candidate for wound healing applications.

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Characterization of polyherbal-incorporated polycaprolactone nanofibrous mat for biomedical applications

Cited by 5 publications

References 13 publications

Synthesis, characterization, and antimicrobial properties of novel dual drug loaded electrospun mat for wound dressing applications

Synthesis, characterization, and antimicrobial properties of novel dual drug loaded electrospun mat for wound dressing applications

Identification and Characterization of Shogaol and 6-Gingerol Complex From Madurese Herbal Medicine

Development of Cissus quadrangularis-Loaded POSS-Reinforced Chitosan-Based Bilayer Sponges for Wound Healing Applications: Drug Release and In Vitro Bioactivity

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