Antiviral activities of Radix Isatidis polysaccharide against type II herpes simplex virus in vitro

Wang, Chunmei; Ruan, Shiman; Gu, Xun; Zhu, Bin

doi:10.1590/1678-457x.19317

Cited by 13 publications

(6 citation statements)

References 12 publications

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“…The polysaccharide compounds contained in I. radix also have anti-influenza virus activity, as demonstrated by in vitro investigations. It has been reported that a polysaccharide isolated from I. radix inhibited the attachment of the influenza virus to the red blood cells, which promoted the generation of anti-influenza viral IgG antibodies [88]. In a study carried out by Li et al [87], I. radix polysaccharides showed potent anti-influenza A virus activity against human seasonal influenza viruses (H1N1 and H3N2) and avian influenza viruses (H6N2 and H9N2).…”

Section: Antimicrobial and Antiviral Activitiesmentioning

confidence: 97%

“…The in vitro antiviral efficacy of the I. radix polysaccharide against type II herpes simplex virus (HSV-2) has been recently demonstrated [88]. Using the 3-(4,5-dimethylthiazole-2-yl)-2,5diphenyltetrazolium bromide (MTT) assay, this effect was shown to occur mainly by inhibiting the viral duplication and adsorption.…”

Section: Antimicrobial and Antiviral Activitiesmentioning

confidence: 99%

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Isatis tinctoria L. (Woad): A Review of Its Botany, Ethnobotanical Uses, Phytochemistry, Biological Activities, and Biotechnological Studies

Speranza

Miceli

Taviano

et al. 2020

Plants

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Isatis tinctoria L. (Brassicaceae), which is commonly known as woad, is a species with an ancient and well-documented history as an indigo dye and medicinal plant. Currently, I. tinctoria is utilized more often as medicinal remedy and also as a cosmetic ingredient. In 2011, I. tinctoria root was accepted in the official European phytotherapy by introducing its monograph in the European Pharmacopoeia. The biological properties of raw material have been known from Traditional Chinese Medicine (TCM). Over recent decades, I. tinctoria has been investigated both from a phytochemical and a biological point of view. The modern in vitro and in vivo scientific studies proved anti-inflammatory, anti-tumour, antimicrobial, antiviral, analgesic, and antioxidant activities. The phytochemical composition of I. tinctoria has been thoroughly investigated and the plant was proven to contain many valuable biologically active compounds, including several alkaloids, among which tryptanthrin, indirubin, indolinone, phenolic compounds, and polysaccharides as well as glucosinolates, carotenoids, volatile constituents, and fatty acids. This article provides a general botanical and ethnobotanical overview that summarizes the up-to-date knowledge on the phytochemistry and biological properties of this valuable plant in order to support its therapeutic potential. Moreover, the biotechnological studies on I. tinctoria, which mainly focused on hairy root cultures for the enhanced production of flavonoids and alkaloids as well as on the establishment of shoot cultures and micropropagation protocols, were reviewed. They provide input for future research prospects.

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Section: Antimicrobial and Antiviral Activitiesmentioning

confidence: 97%

Section: Antimicrobial and Antiviral Activitiesmentioning

confidence: 99%

Isatis tinctoria L. (Woad): A Review of Its Botany, Ethnobotanical Uses, Phytochemistry, Biological Activities, and Biotechnological Studies

Speranza

Miceli

Taviano

et al. 2020

Plants

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show abstract

“…It has the effects of clearing heat, detoxifying, and cooling blood, which can be used for wind-heat cold, epidemic encephalitis, mumps, and hepatitis [2,3]. Modern pharmacological research has confirmed that polysaccharides present in R. isatidis and F. isatidis show antibacterial, antiviral, and immuneenhancing biological activities [4][5][6], which are consistent with the efficacy of CBG. As a result, it is more scientific and reasonable to use polysaccharides analysis as an indicator to evaluate and control the quality of CBG.…”

Section: Introductionmentioning

confidence: 85%

Establishment and application of characteristic degradation fingerprint for the quality control of Compound Banlangen Granules polysaccharides

Liu

et al. 2023

J of Separation Science

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Compound Chinese medicine preparation is a complex multi-component system. The traditional methods such as physicochemical identification and quantification of several main index components cannot provide adequate quality evaluation for Compound Banlangen Granules. The objective of this work was to establish a characteristic degradation fingerprint of Compound Banlangen Granules polysaccharides, and the reference fingerprint was obtained from the model samples prepared using prescription medicinal herbs from different origins. The partial degradation products of Compound Banlangen Granules polysaccharides were profiled by capillary zone electrophoresis, and the quality difference of polysaccharides of these preparations was compared by cluster analysis and principal component analysis. It was found that the contents and the characteristic degradation fingerprints of the polysaccharides from 25 batches of Compound Banlangen Granules of 17 manufacturers were significantly different.The quality of Compound Banlangen Granules polysaccharides was evaluated by the characteristic degradation fingerprint tool with satisfactory results. The present method provides a reference for the quality control strategy development of polysaccharides in other compound Chinese medicine preparations.

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“…It is likely that realgar interacts with bacterial proteins and enzyme proteins, hindering the exchange of substances between bacteria and their environment, thereby exerting bactericidal effects. [19,20] Realgar has also been shown to enhance the defense of Caenorhabditis elegans against Enterococcus faecalis by eliciting immune responses and inducing protective reactions. [21] However, the specific antibacterial and antiviral mechanisms of realgar require further exploration.…”

Section: Modern Pharmacological Research On Realgarmentioning

confidence: 99%

Realgar toxicity in terms of its chemical characterization, pharmacological mechanisms, and metabolic profile: A review

Yi,

Li,

Zhao

et al. 2023

Sci Tradit Chin Med

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Realgar is an arsenic-containing Chinese medicine known for its toxin-removing, phlegm-dispelling, and malaria-intercepting effects. It has proven to be effective in the treatment of acute promyelocytic leukemia. However, because of the harmful nature of arsenic to human health, realgar is considered a “poison” in many countries, raising concerns about the toxicity and safety of realgar and its preparations. The Shuifei process (grinding with water) of realgar plays a crucial role in ensuring its safety as a Chinese medicine. The major ingredient of realgar, As4S4, is water insoluble and poorly absorbed by the human body. Therefore, it is important to note that the toxicity and health risks of realgar to humans are overestimated by solely considering the amount of arsenic. Realgar processing is an indispensable method to ensure the quality of medicinal realgar, involving purification, powdering, detoxification, and synergism. This article not only highlights possible mechanisms through which realgar exerts pharmacological effects but also reviews the literature regarding its toxic features and potential mechanisms. Currently, realgar toxicity research primarily relies on animal experiments, and clinical data on its adverse reactions are relatively limited. The toxicity of arsenic is closely related to the form and valence of its major metabolites in the body. Animal studies have confirmed that, when realgar enters the body, the major form of arsenic metabolized is dimethylarsenic acid; therefore, it was considered that the toxicity of realgar induced by high doses might be associated with the accumulation of dimethylarsenic acid produced in the methylation pathway of inorganic arsenic. Realgar is generally less toxic when used in safe doses, but prolonged use may pose a significant risk. It is rarely used alone and is often combined with other Chinese medicines in an attempt to reduce toxicity. Scientifically and reasonably limiting the arsenic content of realgar-containing Chinese patent medicines is an effective way to improve the safety of realgar in clinical medication.

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Antiviral activities of Radix Isatidis polysaccharide against type II herpes simplex virus in vitro

Cited by 13 publications

References 12 publications

Isatis tinctoria L. (Woad): A Review of Its Botany, Ethnobotanical Uses, Phytochemistry, Biological Activities, and Biotechnological Studies

Isatis tinctoria L. (Woad): A Review of Its Botany, Ethnobotanical Uses, Phytochemistry, Biological Activities, and Biotechnological Studies

Establishment and application of characteristic degradation fingerprint for the quality control of Compound Banlangen Granules polysaccharides

Realgar toxicity in terms of its chemical characterization, pharmacological mechanisms, and metabolic profile: A review

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