Fertility Enhancing Potency of Omega-3 Fatty Acids in Male Rats

Abstract

Cases of some grave side effects of some allopathic medicines used in treatment of infertility has caused a global need for alternatives with minimal or no side effect, hence the demand to evaluate the fertility enhancing potential of omega-3 fatty acids (O3FA) in male rats. This study evaluated the fertility enhancing potential of omega-3 fatty acids (O3FA) in male rats. Seventy-two sexually mature male albino rats 11-13 weeks of age, weighing between 171-180 g were assigned into six groups (I-VI) fed graded doses of O3FA. Administration of O3FA lasted twenty-eight days at 48 hour intervals. At the end of the treatment, organosomatic index of testes, testicular and epididymis sperm cells counts and testicular histology were assessed following standard methods. The actual and relative testicular weights, testicular and epididymis sperm counts of all O3FA treated rats were significantly increased (p < 0.05) when compared with the control group rats. The photomicrographs of testes in O3FA treated rats showed normal spermatogonial cell layers and active spermatogenesis with appearance of spermatids in the lumen of some tubules.

Omega-3 fatty acids dietary intake for oocyte quality in women undergoing assisted reproductive techniques: A systematic review

“…The interest was raised by the recent and promising findings of both animal and human studies. As a first step, multiple animal studies were conducted to test the biological plausibility of the relation between omega-3 intake and fertility focusing on their action on key processes such as steroidogenesis, oocyte maturation and embryo implantation but also male potency and sperm quality [7,32,37,39,41]. As a recent remark, alterations in the murine ovarian gene expression after a highfat diet was improved upon supplementation with omega-3 FAs [16].…”

Infertilidade masculina: principais causas e terapêuticas emergentes, uma revisão

“…As descobertas deste estudo revelam que o O3FA possui a potência de aumentar vários índices de fertilidade em ratos machos com relação ao peso total e relativo dos testículos e contagem de espermática. Ele também pode melhorar a histoarquitetura e a função testicular (Nnamonu et al, 2019).…”

Evaluation of lambda-cyhalothrin oxidative stress and gonad histoarchitecture toxicity potency in Clarias gariepinus

“…Toxically LCT forms a high level of free radicals, which induce oxidative stress. Exposure to toxic chemicals and environmental pollutants damage the histoarchitecture of gonads (Nnamonu, Mgbenka, & Mbegbu, 2019). Gonads are highly susceptible to oxidative stress because their plasma membranes contain high concentration of polyunsaturated fatty acids (Alvarez & Storey, 1995;Nnamonu et al, 2019), and their cytoplasm contains low concentrations of scavenging enzymes (De Lamirande & Gagnon, 1995;Nnamonu et al, 2019).…”