Omega-3 fatty acids dietary intake for oocyte quality in women undergoing assisted reproductive techniques: A systematic review

Abodi, Martina; Cosmi, Valentina De; Parazzini, Fabio; Agostoni, Carlo

doi:10.1016/j.ejogrb.2022.06.019

Cited by 9 publications

(8 citation statements)

References 47 publications

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“…Similarly, in humans, women who were obese had lower levels of saturated fatty acids and polyunsaturated n-3 fatty acids across all studied stages of oocyte development, and https://doi.org/10.1017/S000711452300017X Published online by Cambridge University Press overweight women had lower n-3 fatty acids in Metaphase II oocytes, which can contribute to alter embryo development and metabolism at the cell signaling level (70) . LC n-3 PUFAs given to infertile women improve oocyte quality (71) , so that, beyond their positive effect on fertility, they could also participate to improve fetal programming in obese.…”

Section: Discussionmentioning

confidence: 99%

Long-chainn-3 PUFA given before and throughout gestation and lactation in rats prevent high-fat diet-induced insulin resistance in male offspring in a tissue-specific manner

Guriec¹,

Foll

Delarue

2023

Br J Nutr

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This study investigated whether long chain n-3 polyunsaturated fatty acids (LC n-3 PUFAs) given to pregnant rats fed a high fat (HF) diet may prevent fetal programming in male offspring at adulthood. Six weeks before mating, and throughout gestation and lactation, female nulliparous Sprague-Dawley rats were given a chow (C) diet, HF (60.6% fat from corn, rapeseed oils and lard) or HF in which one third of fat was replaced by fish oil (HF n-3). At weaning, the 3 offspring groups were randomly separated in 2 groups fed C diet, or HF without LC n-3 PUFAs, for 7 weeks until adulthood. Glucose tolerance and insulin sensitivity were assessed by an oral glucose tolerance test both at weaning and at adulthood. Insulin signaling was determined in liver, muscle and adipose tissue by quantification of the phosphorylation of Akt on Ser 473 at adulthood. At weaning, as at adulthood, offspring from HF-fed dams were obese, and displayed glucose intolerance (GI) and insulin-resistance (IR), but not those from HFn-3 fed dams. Following the post-weaning C diet, phosphorylation of Akt was strongly reduced in all tissues of offspring from HF dams, but to a lesser extent in liver and muscle of offspring from HFn-3 dams. However, it was abolished in all tissues of all offspring groups fed the HF post-weaning diet. Thus, LC n-3 PUFAs introduced in a HF in dams, partially prevented the transmission of GI and IR in adult offspring even though they were fed without LC n-3 PUFAs from weaning.

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Section: Discussionmentioning

confidence: 99%

Long-chainn-3 PUFA given before and throughout gestation and lactation in rats prevent high-fat diet-induced insulin resistance in male offspring in a tissue-specific manner

Guriec¹,

Foll

Delarue

2023

Br J Nutr

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“…Oocytes can accommodate large amounts of lipid droplets, and their absorption in the embryos is critical, being the main factor responsible for the accumulation of ATP through mitochondrial oxidation [42]. Abazarikia et al [43] state that the inclusion of CLA in oocyte maturation and in vitro embryo culture can affect the modulation of lipogenesis.…”

Section: Discussionmentioning

confidence: 99%

Gastric administration of Cis-9, trans-11 and trans-10, cis-12 conjugated linoleic during the pregestational and gestational periods does not influence the follicular endowment of the progeny

Freitas

Lopes

Nascimento

et al. 2022

Preprint

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Fetal programming suggests that maternal stimulation and nutrition during the period of fetal development can program the progeny. Conjugated linoleic acid (CLA), an isomer of linoleic acid, has been characterized in several aspects, but few studies have been performed on its involvement in reproduction and fetal programming. The aim of this study was to evaluate the F1, F2 and F3 progeny of female mice supplemented with CLA during the pregestational and gestational periods with respect to biometric and reproductive parameters, as well as ovarian morphophysiology. The F1 progeny of mothers supplemented with CLA exhibited stable weight gain, while the F2 progeny showed no effects (P=0.0187 and P=0.0245, respectively). A reduction in Lee's Index was observed in both generations at the second post-weaning evaluation week in the animals treated with CLA (P=0.0100 and P=0.0078, respectively). The F2 generation showed an increase in the anogenital index in both sexes of the animals treated with CLA (P= 0.0114 and P<0.0001, female and male respectively). CLA administration to mothers did not affect any of the following in their progeny: ovarian follicle mobilization (P>0.05), follicle number (P>0.05) and the integrated density of the lipid content of oocytes included in antral follicles (P>0.05). This study evaluated the use of CLA in mothers and found that it did not affect the progeny regarding murine reproductive performance, suggesting that this supplement can be used safely.

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“…Types of fats have different effects on male reproduction functions, such as saturated fats (SFs), trans fatty acids (TFA) and polyunsaturated fatty acids (PUFAs). Studies on using saturated fat to treat male infertility are conflicting [ 9 ]. Previous investigations exhibited a significant correlation between the intakes of increased SFs to deteriorating sperm accounts by 38%.…”

Section: Dietary Nutrientsmentioning

confidence: 99%

“…As it is well known, food is critical for all people to get energy and carry out all indispensable developments, such as reproduction [ 8 ]. Providing many active nutrients is essential for all the developmental periods in humans, including growth, puberty, maturity, and reproduction [ 9 ]. Following nutritious/well-proportioned food and being physically active are two centers of a healthy lifestyle.…”

Section: Introductionmentioning

confidence: 99%

“…Thus, diet fortifications with antioxidants have exhibited a constructive influence on fertility competence. More randomized controlled studies are desirable to validate the efficiency and safety of micronutrients and antioxidant additions in decreasing male infertility, as well as to discover the optimum dose of each antioxidant and micronutrient to increase fertility competence [ 9 , 13 ]. Results demonstrated a potentially great public interest since fluctuations in diet over the last periods may be part of the clarification for the recently described high incidence of subnormal human sperm amounts.…”

Section: Introductionmentioning

confidence: 99%

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The Role of Dietary Nutrients in Male Infertility: A Review

Almujaydil

2023

Life

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Male infertility is the main health issue with economic, psychological, and medical attributions. Moreover, it is characterized by an inability to produce a sufficient amount of sperm for the fertilization of an oocyte. Dietary nutrients (DN) have a great effect on male reproductive potential. Observations have indicated that adding DN may protect or treat male infertility. The scope of this criticism is to scrutinize the DN, such as omega-3 fatty acids, vitamins, minerals and other phytochemicals, in enhancing the semen attributes, sperm bioenergetics and sperm functionality in male infertility. It seems that diets rich in omega-3 fatty acids affect sperm quality and maintain the sperm membrane and mitochondria stability. An administration of phytochemicals caused an escalation in sperm mitochondrial function and a decrease in oxidative damage. Furthermore, sundry dietary natural phytochemicals differentially affect (negatively or positively) sperm motility, semen quality, and mitochondrial function, dependent on their levels. Vitamins and trace elements are also nutritional modulators in reducing oxidative stress, thereby enhancing sperm quality, which is accurately connected with sperm mitochondrial function. Also, we described the different types of DN as mitochondrial enhancer for sperm functionality and health. We believe that understanding the DN supports sperm mitochondria and epigenetic modulators that may be responsible for sperm quality and health, and will lead to more embattled and efficient therapeutics for male infertility.

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Omega-3 fatty acids dietary intake for oocyte quality in women undergoing assisted reproductive techniques: A systematic review

Cited by 9 publications

References 47 publications

Long-chainn-3 PUFA given before and throughout gestation and lactation in rats prevent high-fat diet-induced insulin resistance in male offspring in a tissue-specific manner

Long-chainn-3 PUFA given before and throughout gestation and lactation in rats prevent high-fat diet-induced insulin resistance in male offspring in a tissue-specific manner

Gastric administration of Cis-9, trans-11 and trans-10, cis-12 conjugated linoleic during the pregestational and gestational periods does not influence the follicular endowment of the progeny

The Role of Dietary Nutrients in Male Infertility: A Review

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