Neuroprotective potential of lignan-rich fraction of Piper cubeba L. by improving antioxidant capacity in the rat's brain

Abstract

Piper cubeba contains various types of lignans. These compounds have been found to have potential pharmacological activities, one being a neuroprotector through an antioxidant mechanism, especially in the brain. This study examined the antioxidant activity of the lignan-rich fraction of P. cubeba (LF) in rat brains. The rats were given LF (200 and 400 mg/kg), Vitamin C (200 mg/kg), and a carrier as the control group for one-week p.o. The following day, rat brains were collected for antioxidant tests, including examining lipid peroxide inhibition, superoxide dismutase and catalase activity, and determination of nitric oxide (NO) concentration. The phytochemical compounds were analyzed with thin-layer chromatography (TLC), ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS), and gas chromatography-mass spectrometry (GC-MS). Test results show that the LF of both doses of 200 and 400 mg/kg could significantly increase antioxidant activity in the brain by inhibiting lipid peroxidation. LF could also increase catalase, despite the decrease in superoxide dismutase activity. Reduction in NO only occurred in the LF-200 group, while LF-400 showed insignificant results compared to the control group. In conclusion, LF showed potential as an antioxidant in the brain and could be beneficial for treating neurological diseases.

Diosgenin normalization of disrupted behavioral and central neurochemical activity after single prolonged stress

“…Increased oxidative stress is responsible for neuronal damage in the frontal cortex and hippocampus ( MacPherson et al, 2005 ), which is likely to impair learning. Vitamin C has an antioxidant potential that helps to oppose neurodegeneration in several ailments by conserving the antioxidant mechanism in the brain, imparting neuroprotection ( Dwita et al, 2023 ), and ameliorating memory by restoring antioxidant mechanisms in the hippocampus. Through oxidation, vitamin C is hypothesized to shield cellular DNA, lipids, and proteins from oxidative damage caused by ROS and this can improve cognition ( Alqudah et al, 2018 ).…”

Eco-Friendly Piper cubeba official extract corrosion inhibition of c-steel in 1M sulphamic acid

“…In addition to rutin (8 ppm) and catechin (5 ppm), researchers found that the aqueous extract of piper cubeba fruits also contained gallic acid (8 ppm), caffeic acid (13 ppm), syringic acid (3 ppm), and ferulic acid (11 ppm[21]. The aqueous extract from the same study contained 2.11 mg/g of total phenols [22].In some literature, oxygen atoms, and aromatic rings are considered the centers of adsorption in the four ingredients [22,23]. As a result, (P.cubebaOE) may be studied as an environmentally friendly corrosion inhibitor.…”

The study of identification, collection, and authentication of fruits of Piper cubeba

“…Additionally, some unanswered questions and possible applications for the future are highlighted. Dwita, Lusi & Iwo, M. &Mauludin, R. (2022) [4] Piper cubeba has a large diversity of lignans. These chemicals have antioxidant properties that could be useful in medicine, especially in the brain where they prevent neuronal damage.…”