Diosgenin normalization of disrupted behavioral and central neurochemical activity after single prolonged stress
Hurmat Malik,
Muhammad Usman,
Mehreen Arif
et al.
Abstract:Introduction: Post-traumatic stress disorder (PTSD) is a chronic mental illness triggered by traumatic experiences such as wars, natural disasters, or catastrophes, and it is characterized by anxiety, depression and cognitive impairment. Diosgenin is a steroidal sapogenin with known neuroprotective and antioxidant properties. This study aimed to assess the pharmacological potential of diosgenin in a single prolonged stress (SPS) model of PTSD, plus other behavioral models along with any consequent alterations … Show more
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