Antiulcerogenic and antioxidant activities of Plantago ovata ethanolic extract in rats

Abstract

This study aimed to determine the antiulcerogenic and antioxidant activities of Psyllium (Plantago ovata Forssk) seed ethanolic extract in rats. We assessed the antioxidant potential using free radical scavenging on DPPH, β-carotene bleaching activity, ferric reducing power, and hydroxyl radical scavenging activity. In the antiulcerogenic study, pre-treatment with Plantago ovata seeds ethanolic extract (POE) (400 mg/kg b.wt) significantly protected against ethanol-induced gastric ulcer in rats by decreasing the ulcer index value and preserving the integrity of the gastric mucosa. The oxidative stress status in the stomach tissues showed a significant increase in the antioxidant enzyme levels of superoxide dismutase, catalase, and glutathione peroxidase with a significant decrease in lipid peroxidation during pre-treatment with POE. In conclusion, the POE protects against gastric ulcer due to its antioxidant potential and presence of bioactive molecules.

Therapeutic Efficacy of a Formulation Prepared with Linum usitatissimum L., Plantago ovata Forssk., and Honey on Uncomplicated Pelvic Inflammatory Disease Analyzed with Machine Learning Techniques

“…Khedher et al determined the antioxidant and antiulcerogenic properties of psyllium seed ethanolic extract in rats and reported that during pre-treatment with psyllium, the oxidative stress status in the stomach tissues showed a significant increase in SOD, CAT, and GPx (antioxidant enzyme levels) with a significant decrease in lipid peroxidation. In conclusion, psyllium extract protects against gastric ulcers because of its antioxidant effect and the presence of bioactive molecules [ 21 ]. The phytochemical evaluation of the psyllium extract exhibited high numbers of flavonoids, polyphenols, and tannins possibly responsible for its anti-oxidative effect [ 95 ].…”

“…Tannins are recognized to ‘tan’ the mucosal outermost layer, interpreting it as less permeable and more resistant to injury or irritation [ 108 ]. The protective effects are associated with the antioxidant activities and antiradical power of psyllium extract [ 21 ]. The anti-inflammatory potential of honey is due to its phenolic content [ 109 ].…”

“…Then onwards, all the participants were advised to take a tablet of pantoprazole 20 mg twice daily before eating food to avoid side effects. Khedher [ 21 ] investigated and tested animals that received different doses of Psyllium extract (100–1000 mg/kg). The data showed no acute toxicity or lethality up to 1000 mg/kg.…”

“…Pharmacologically, psyllium has been proven to have antibacterial, analgesic, antipyretic, and anti-inflammatory properties, and nephroprotective and hepatoprotective properties [ 17 ] in mice. Other studies on P. ovata have also proven it to have antimicrobial [ 18 , 19 ], anti-inflammatory, antipyretic [ 20 , 21 ] and antioxidant activities [ 22 ]. The aucubin in the seeds is responsible for its antibacterial properties.…”

Role of Psyllium Husk (Plantago ovata) on Liver Function Alterations Induced by Carbon Tetrachloride (CCl4) in Adult Male Albino Rats

“…Species of Plantago are characterized by the presence of phenolic compounds that play important roles in absorbing and neutralizing free radicals, quenching singlet and triplet oxygen, or decomposing peroxides. Phenolics, flavonoids and condensed tannins have shown ideal structural chemistry for free radical scavenging activity (Khedher et al,2022).…”