Role of Psyllium Husk (Plantago ovata) on Liver Function Alterations Induced by Carbon Tetrachloride (CCl4) in Adult Male Albino Rats

Mostafa, Amna; Allam, Eman; Alghriany, Alshaimaa

doi:10.21608/eajbsd.2022.261160

Cited by 2 publications

(5 citation statements)

References 10 publications

(11 reference statements)

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“…Numerous essential biological components, including proteins, nucleic acids, lipids, amino acids, and nucleotides, interact with the trichloromethyl free radical. The trichloromethyl peroxy radical is produced from the free trichloromethyl radical (Mostafa et al, 2022). The trichloromethyl peroxy radical is far more likely than the trichloromethyl free radical to take hydrogen from polyunsaturated fatty acids, which starts the process of lipid peroxidation.…”

Section: Discussionmentioning

confidence: 99%

“…This could be explained by the fact that the intoxicated rats only got PSH for a brief period of time and that the amount of psyllium given to the CCl4+PS group was lower than that given to the PS+CCl4 group. ( Sharma & Shukla, 2011;Mostafa et al, 2022) found that the antioxidant was ineffective in treating the liver at low doses and that histology findings indicated modest generation.…”

Section: Discussionmentioning

confidence: 99%

“…PSH was ground into powder. Each rat got 0.5g/kg body weight (Ahmed et al, 2010;Mostafa et al, 2022)orally in 2ml of water, and weights were taken every week.…”

Section: Methodsmentioning

confidence: 99%

“…Two mg of CCl4 were mixed in two milliliters of olive oil, and each rat received 0.5 mg/kilogram of body weight of the prepared solution twice/week (EL Sayed et al, 2019;Mostafa et al, 2022).…”

Section: Ccl4 and Olive Oil Solution Preparationmentioning

confidence: 99%

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Ameliorative Role of Psyllium Husk on Hepatotoxicity Induced by CCL4 in Male Albino Rats: A Histological and Immunohistochemical Study

Mostafa

Allam

Alghriany

2023

Egyptian Academic Journal of Biological Sciences, B. Zoology

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Carbon tetrachloride (CCl4) is a strong hepatotoxin that is commonly used to induce experimental liver injury to investigate a substance's potential hepatoprotective effects. Plantago ovata husk (PSH) contains a variety of primary and secondary metabolites, as well as a number of bioactive compounds that have strong antioxidant properties. The goal of this study was to determine whether PSH powder could protect and treat adult male albino rats' livers from CCl4-induced damage. Five groups were created: A: (Control group) received nothing. Oil was administered in B (Oil treated group). C: (CCl4 treated) group. D: (PS+CCl4) treated group, which received daily PSH for six weeks and CCl4 for four weeks. E: (CCl4+PS) treated group, after giving them CCl4, they received daily PSH. Histological and immunohistochemical examinations were carried out. Homogenized liver samples were analyzed for antioxidant enzymes; statistical analysis was performed. The intraperitoneal injection of CCl4 resulted in a significant rise in SOD, GPx, and MDA, as well as various lesions in hepatocytes, including cytoplasmic vacuolations, leukocyte infiltration, necrosis, collagen deposition, and a high level of caspase-3. Treatment by PSH in both groups ameliorated the effect of CCl4 on decreasing antioxidant enzymes. PSH in the PS+CCl4 group showed nearly normal histological structure of the liver, collagen deposition, and Caspase-3 levels. It could be concluded that PSH powder acts as a strong antioxidant that can be used in daily life for protection and curation from liver diseases.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…PSH was ground into powder. Each rat got 0.5g/kg body weight (Ahmed et al, 2010;Mostafa et al, 2022)orally in 2ml of water, and weights were taken every week.…”

Section: Methodsmentioning

confidence: 99%

Section: Ccl4 and Olive Oil Solution Preparationmentioning

confidence: 99%

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Ameliorative Role of Psyllium Husk on Hepatotoxicity Induced by CCL4 in Male Albino Rats: A Histological and Immunohistochemical Study

Mostafa

Allam

Alghriany

2023

Egyptian Academic Journal of Biological Sciences, B. Zoology

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“…Various sources of free radicals or superoxide radicals can be neutralized by antioxidant enzymes. In CCl4-induced oxidative stress rats, Mostafa, et al [54] showed that GNL reversed the expression of catalase, glutathione peroxidase, and glutathione-S-transferase, and reduced glutathione in the liver tissues [54]. GNL also reverses isoproterenol's suppression of catalase, glutathione peroxidase and glutathione-S-transferase activity, and mRNA expression [55].…”

Section: Glutathione Modulation By Gnlmentioning

confidence: 99%

Potential Effects of Geraniol on Cancer and Inflammation-Related Diseases: A Review of the Recent Research Findings

Ammar

2023

Molecules

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Geraniol (GNL), a natural monoterpene, is found in many essential oils of fruits, vegetables, and herbs, including lavender, citronella, lemongrass, and other medicinal and aromatic plants. GNL is commonly used by the cosmetic and food industries and has shown a wide spectrum of pharmacological activities including anti-inflammatory, anticancer, antimicrobial, antioxidant, and neuroprotective activities. It represents a potential anti-inflammatory agent and a promising cancer chemopreventive agent, as it has been found to be effective against a broad range of cancers, including colon, prostate, breast, lung, skin, kidney, liver, and pancreatic cancer. Moreover, GNL scavenges free radicals and preserves the activity of antioxidant enzymes. In addition, GNL induces apoptosis and cell cycle arrest, modulates multiple molecular targets, including p53 and STAT3, activates caspases, and modulates inflammation via transcriptional regulation. In the present study, different modes of action are described for GNL’s activity against cancer and inflammatory diseases. This compound protects various antioxidant enzymes, such as catalase, glutathione-S-transferase, and glutathione peroxidase. Experiments using allergic encephalomyelitis, diabetes, asthma, and carcinogenesis models showed that GNL treatment had beneficial effects with low toxicity. GNL has been shown to be effective in animal models and tumor cell lines, but there have not been any clinical studies carried out for it. The aim of the present review is to provide updated data on the potential effects of GNL on cancer and inflammation, and to enhance our understanding of molecular targets, involved pathways, and the possible use of GNL for clinical studies and therapeutic purposes in the treatment of cancer and inflammation-related diseases.

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Role of Psyllium Husk (Plantago ovata) on Liver Function Alterations Induced by Carbon Tetrachloride (CCl4) in Adult Male Albino Rats

Abstract: Article History

Cited by 2 publications

References 10 publications

Ameliorative Role of Psyllium Husk on Hepatotoxicity Induced by CCL4 in Male Albino Rats: A Histological and Immunohistochemical Study

Ameliorative Role of Psyllium Husk on Hepatotoxicity Induced by CCL4 in Male Albino Rats: A Histological and Immunohistochemical Study

Potential Effects of Geraniol on Cancer and Inflammation-Related Diseases: A Review of the Recent Research Findings

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