Anticonvulsant effects of desvenlafaxine on modulating brain monoamine and oxidative stress in mice

Alharbi, Khalid Saad

doi:10.1590/1519-6984.246194

Cited by 2 publications

(3 citation statements)

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“…In this investigation 80 mg/kg of pioglitazone was dissolved in 0.1% carboxymethyl cellulos (w/v) and given to the mice orally (Rajaba et al, 2014). To induce seizure, 400 mg/kg of pilocarpine (a single dose) was administered intraperitoneally (IP) (Figure 1) (Alharbi, 2021).…”

Section: Methodsmentioning

confidence: 99%

“…Seizures, Alzheimer's disease, stroke, and migraine are the most common neurological ailments related to epilepsy (Farrell et al, 2017;Azimi and Asgarpanah, 2021;Alharbi, 2021). According to research, seizures have been demonstrated to attack neurons by causing oxidative stress and generating free radicals (Patel, 2002(Patel, , 2004Lin et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

“…84, e260091 2/6 Abdelbasset, W.K. et al pilocarpine in large dosages harms the hippocampus's GABAergic (gamma-aminobutyric acidergic) neurons, which finally leads to status epilepticus is one way to induce seizure in rodents (Freitas et al, 2004;Alharbi, 2021). Pioglitazone, an agonist of the Peroxisome Proliferator-Activated Receptor -γ nuclear receptor, improves insulin receptor sensitivity and is used to treat type 2 diabetes (Yap et al, 2020).…”

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confidence: 99%

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Treatment of pilocarpine-induced epileptic seizures in adult male mice

et al. 2024

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Epilepsy is one of the most common neurological disorders affecting most social, economic and biological aspects of human life. Most patients with epilepsy have uncontrolled seizures and drug side effects despite the medications. Patients with epilepsy often have problems with attention, memory, and information processing speed, which may be due to seizures, underlying causes, or anticonvulsants. Therefore, improving seizure control and reducing or changing the anti-epileptic drugs can solve these problems, but these problems will not be solved in most cases. In this work, we looked at the effects of pioglitazone, a Peroxisome Proliferator-Activated Receptor agonist used to treat type 2 diabetes, on pilocarpine-induced seizures in mice. The Racine scale was used to classify pilocarpine-induced convulsions. After that, all of the animals were beheaded, and the brain and hippocampus were dissected. Finally, biochemical techniques were used to determine the levels of Malondialdehyde and Catalase activity, as well as Superoxide Dismutase and Glutathione Reductase in the hippocampus. The results of this investigation suggest that pioglitazone's antioxidant action may play a key role in its neuroprotective properties against pilocarpine-induced seizure neuronal damage.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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confidence: 99%

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Treatment of pilocarpine-induced epileptic seizures in adult male mice

et al. 2024

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Anticonvulsive and Antioxidant Effects of Pioglitazone on Pilocarpine-induced Seizures in Mice

Rostamian

Hedayati

Khosraviani

et al. 2021

IJT

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Background: Epilepsy is a neurological disorder caused by uncontrollable discharge of action potentials from neurons in the brain. After a seizure, oxidative stress may cause a significant neuronal damage. In the current study, we assessed the anticonvulsant and antioxidant properties of pioglitazone, a peroxisome proliferated activated receptor-γ (PPAR-γ) agonist that is used in type-2 diabetes, on pilocarpine-induced seizure in mice. Methods: Pilocarpine (400 mg/kg) or normal saline was injected intraperitoneally 4 hours after oral administration of Pioglitazone (80 mg/kg). Also, carboxymethyl cellulose was administered orally in control and Pilocarpine groups. After the administration of Pilocarpine all of the mice were observed for 1 hour to measure the seizure latency time. Pilocarpine-induced seizures were categorized using the Racine scale. Then all animals were decapitated, brain was removed and hippocampus was dissected. Finally, the level of Malondialdehyde (MDA) and Catalase (CAT) activity, Superoxide Dismutase (SOD), and Glutathione Reductase (GR) levels were quantified in hippocampus by biochemical methods. Results: Pioglitazone significantly increased the latency to seizure onset of stages 1-4 (P≤0.01-0.001). Also, pioglitazone prevented the development of stage 5 of the pilocarpine-induced seizure. After the seizure, pioglitazone significantly decreased the level of MDA (P<0.01) and elevated the levels of CAT (P<0.01), SOD (P<0.01) and GR (P<0.001) enzymes in the mice hippocampus compared to those in the pilocarpine group. Conclusion: The findings of this study indicate that the antioxidant effect of pioglitazone may play an important role in its protective effects against neuronal damage caused by pilocarpine-induced seizure.

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Anticonvulsant effects of desvenlafaxine on modulating brain monoamine and oxidative stress in mice

Cited by 2 publications

References 31 publications

Treatment of pilocarpine-induced epileptic seizures in adult male mice

Treatment of pilocarpine-induced epileptic seizures in adult male mice

Anticonvulsive and Antioxidant Effects of Pioglitazone on Pilocarpine-induced Seizures in Mice

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