Combate à deficiência de vitamina A: linhas de ação e perspectivas

Diniz, Alcides da Silva

doi:10.1590/1519-38292001000100004

Rev. Bras. Saude Mater. Infant.

2001

DOI: 10.1590/1519-38292001000100004

|View full text |Cite

Combate à deficiência de vitamina A: linhas de ação e perspectivas

Alcides da Silva Diniz

Abstract: Resumo A hipovitaminose A é um dos mais importantes problemas nutricionais nos países em desenvolvimento, tanto em termos de magnitude e distribuição espacial, quanto de efeitos deletérios à saúde. Constitui a principal causa de cegueira prevenível na infância. Estudos ep idemiológicos têm demonstrado o papel crucial da vitamina A na redução da mortalidade infantil e materna; embora os efeitos sobre a morbidade sejam menos consistentes. A distribuição universal de megadoses de vitamina A tem sido a medida emer… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2004

2022

Publication Types

Select...

Article5

Relationship

Self Cite0

Independent5

Authors

Journals

Cited by 6 publications

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Serum vitamin A in mothers and newborns in the city of Rio de Janeiro

Gomes

Saunders

Ramalho

et al. 2009

International Journal of Food Sciences and Nutrition

View full text Add to dashboard Cite

Retinol and carotenoid levels were determined spectrophotometrically in the blood of 222 mothers at delivery and in the umbilical cord of the newborns. We observed an important prevalence of vitamin A deficiency (VAD) among mothers and newborns (25.4% and 46.2%, respectively) as well as carotenoid inadequacy (52.3% and 92.6% in mothers and newborns, respectively), and an increased risk of VAD development among newborns whose mothers had VAD (odds ratio = 4.79). We found an increased risk of carotenoid inadequacy when VAD was already present in both groups (odds ratio = 2.21 and odds ratio = 6.85 in mothers and newborns, respectively). There were relationships between previous abortion and maternal VAD (P=0.022) and lower carotenoid levels among newborns (P=0.019), as well as inadequate maternal serum carotenoid levels and interdelivery interval less than 18 months. These findings suggest the need for interventional actions to prevent retinol and carotenoid inadequacy, and low antioxidant reserves.

show abstract

Serum vitamin A in mothers and newborns in the city of Rio de Janeiro

Gomes

Saunders

Ramalho

et al. 2009

International Journal of Food Sciences and Nutrition

View full text Add to dashboard Cite

show abstract

Impact of dietary vitamin A deficiency on body physiology and liver metabolism of Wistar rats

et al. 2022

View full text Add to dashboard Cite

Background: Studies suggest that vitamin A deficiency (VAD) can cause night blindness or xerophthalmia, hepatic and metabolic changes in the blood. Aim: Therefore, this work aimed to stablish a model of hypovitaminosis A in rats and to evaluate the effects of vitamin A deficiency on metabolic and oxidative parameters in the liver of rats. Methods: Male (n = 19), Wistar, rats (21-day-old) weighing 50g, divided into two experimental groups: Control Group (C), received AIN 93G diet and Vitamin A Deficiency Group (VAD), received AIN 93G vitamin A-free diet for 45 days. In this work, the parameters analyzed were: body mass, food and water intake, biochemical aspects in the blood, lipids and glycogen content, lipid peroxidation, carbonyl proteins and catalase activity in the liver. Results: In the VAD group, final body mass (9%), liver mass (28%), glycemia (14%), Total -cholesterol (17%), HDL -cholesterol (31%) and VLDL -cholesterol (30%) showed reduced ( p < 0.05). The liver lipid (64%) and glyceride-fatty acid (74%) contents were higher in the VAD group. The carbonyl proteins in liver were increased by 171% ( p < 0.05). Conclusion: In summary, these results suggest that the absence of vitamin A from the diet was effective in inducing characteristics of hypovitaminosis A in rats. This way, can be used for studies related to glucose and lipid metabolism.

show abstract

Prescrições de medicamentos para gestantes: um estudo farmacoepidemiológico

Carmo

Nitrini

2004

Cad. Saúde Pública

View full text Add to dashboard Cite

Prescription drug use by pregnant women should be viewed as a public health issue, since there are numerous gaps in knowledge on the consequences for both the mother and the fetus. Pharmacoepidemiological studies can help minimize the inherent risks in drug treatment by establishing a profile of drug consumption during pregnancy, providing an evaluation of this service, and identifying intervention measures. The purpose of this study was to establish a prescription profile for pregnant women treated under the National Health System (SUS) in Piracicaba, São Paulo State, Brazil, using prescription indicators recommended by the World Health Organization and the U.S. Food and Drug Administration classification of medicines according to risk to the fetus. According to the current study, during prenatal consultations 44.7% of the women received drug prescriptions, and the most widely prescribed group of drugs were those acting on the hematopoietic system (34.9%). Of this total, 26.0% of the drugs were included in fetal risk category C, 1.5% in category D, and 1.5% in category E. These data point to the medicalization of pregnancy and the need for intervention measures aimed at rational prescription drug use during the prenatal period.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Combate à deficiência de vitamina A: linhas de ação e perspectivas

Cited by 6 publications

References 20 publications

Serum vitamin A in mothers and newborns in the city of Rio de Janeiro

Serum vitamin A in mothers and newborns in the city of Rio de Janeiro

Impact of dietary vitamin A deficiency on body physiology and liver metabolism of Wistar rats

Prescrições de medicamentos para gestantes: um estudo farmacoepidemiológico

Contact Info

Product

Resources

About