Prescription drug use by pregnant women should be viewed as a public health issue, since there are numerous gaps in knowledge on the consequences for both the mother and the fetus. Pharmacoepidemiological studies can help minimize the inherent risks in drug treatment by establishing a profile of drug consumption during pregnancy, providing an evaluation of this service, and identifying intervention measures. The purpose of this study was to establish a prescription profile for pregnant women treated under the National Health System (SUS) in Piracicaba, São Paulo State, Brazil, using prescription indicators recommended by the World Health Organization and the U.S. Food and Drug Administration classification of medicines according to risk to the fetus. According to the current study, during prenatal consultations 44.7% of the women received drug prescriptions, and the most widely prescribed group of drugs were those acting on the hematopoietic system (34.9%). Of this total, 26.0% of the drugs were included in fetal risk category C, 1.5% in category D, and 1.5% in category E. These data point to the medicalization of pregnancy and the need for intervention measures aimed at rational prescription drug use during the prenatal period.
Introduction: Synthetic phosphoethanolamine (SP), known as "the cancer pill", was presented as a promising medicine for the treatment of tumors. This substance directs its mechanism of action towards the cell membranes by the transduction of signals and metabolism of lipids, which results in apoptosisinduction. Objective: The present study evaluated articles that indicated the use of SP as an inhibitor of the progression and dissemination of tumor cells. It also reviewed the possible mechanisms associated with the action of the molecule on the treatment of tumors. Method: The work is a narrative, exploratory and integrative bibliographic review, based on the following databases: Virtual Health Library, Google Academic, PubMed and Scientific Electronic Library Online (SciELO). Inclusion criteria: complete articles available in Brazilian and international literature, with the words: SP and tumors. Results: The search found a total of65 articles, and, after an analysis of the sources using the method described above, 19 articles describing the effects of synthetic phosphoethanolamine and the possible mechanisms associated with the action of SP on tumors were selected. Conclusion: Phosphoethanolamine is a lipid compound found in high concentration in tumors and is associated with a high rate of apoptosis. Preclinical research studies seek to validate the use of SP for tumor treatment. To date, there is no evidence that supports the efficacy of SP in neoplasms. Clinical studies showing the use of SP to treat tumors are essential for the validation of SP. In April 2017, as SP did not show any clinical efficacy in preliminary trials and clinical trials supported by São Paulo Cancer Institute, studies were suspended with the agreement of the Brazilian Health Regulatory Agency (ANVISA, Brazil). Keywords: ethanolamines; drug evaluation; antineoplastic agents; neoplasms; apoptosis; drug screening assays, antitumor. RESUMO Introdução:A fosfoetanolamina sintética (FS), conhecida como pílula do câncer, foi apresentada como promissora do tratamento de tumores. Essa substância tem seu mecanismo de ação voltado para as membranas celulares pela transdução de sinais e metabolismo de lipídeos que resultam na indução da apoptose. Objetivo: O presente trabalho avaliou os artigos da literatura que relacionam o uso da substância fosfoetanolamina sintética (FS) como inibidor da progressão e disseminação de células tumorais no Brasil. Buscou-se também descrever os possíveis mecanismos associados com a ação da molécula para tratamento de tumores. Método: O trabalho é uma revisão bibliográfica, narrativa, exploratória e integrativa, nas bases de dados Biblioteca Virtual de Saúde, Google acadêmico, Pubmed e Scientific Electronic Library Online (SciELO). Critérios de inclusão: artigos completos disponíveis na literatura nacional e internacional, com palavras FS e tumores. Resultados: A partir de resultados de busca com 65 artigos, foram selecionados 19 artigos. Após análises das fontes de informações acima, foram selecionados os art...
Objetivo: o presente trabalho teve por objetivo descrever a utilização e os resultados obtidos com o instrumento Medical Outcomes Study Short Form -36 item (SF-36) para avaliação de qualidade de vida de pessoas em situação de uso, abuso ou dependência de substâncias psicoativas (SPA). Método: realizou-se um levantamento bibliográfico em artigos e revistas científicas, dissertações e monografias. Resultados: os estudos mostram que o uso de substâncias psicoativas traz prejuízos para saúde e qualidade de vida das pessoas. Conclusão: observa-se que o instrumento SF-36 se mostra válido e confiável para a avaliação da qualidade de vida entre consumidores de SPA e possui em seus domínios algumas dimensões que são bastante sensíveis a avaliação de aspectos da qualidade de vida desta população.
Estudos em ratos realizados antes da liberação do medicamento mostraram toxicidade aguda muito débil. Os Estados Unidos baseado em perícias realizadas pelo Food and Drug Administration (FDA) que demonstraram alterações neurológicas em coelhos adultos proibiram sua comercialização. A França também não permitiu seu uso. (PRESCRIRE INTERNA TIONAL, 1998).
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