Clinical characteristics of women with gestational diabetes - comparison of two cohorts enrolled 20 years apart in southern Brazil

Reichelt, A.; Weinert, Letícia Schwerz; Mastella, Lívia Silveira; Gnielka, Vanessa; Campos, Maria Amélia; Hirakata, Vânia Naomi; Oppermann, Maria Lúcia Rocha; Silveiro, Sandra Pinho; Schmidt, María Inês

doi:10.1590/1516-3180.2016.0332190317

Cited by 16 publications

(18 citation statements)

References 24 publications

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“…За формирование макросомии при ДФ отвечают соматомедины, синтез которых повышается на фоне фетальной гиперинсулинемии и гипергликемии [3,27,29]. Развитие макросомии также связано с чрезмерной пролиферацией клеток плаценты [30].…”

Section: таблицаunclassified

“…Ряд ученых доказали роль инсулиноподобного фактора роста (IGF-2) при формировании макросомии [30]. Ученые исследовали роль IGF-2-производного (интронного miR-483-3p) у 30 беременных с фетальной макросомией и у 30 здоровых беременных.…”

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Physical development of newborns born to mothers with different carbohydrate metabolism disorders

Харитонова¹,

Папышева²,

Богомаз³

et al. 2019

Eksp. Klin. Gastroenterol.

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РезюмеВведение: ежегодно от 50 до 150 тысяч младенцев рождается от матерей с сахарным диабетом. В настоящее время нет сомнений в том, что состояние новорожденных, родившихся от матерей с сахарным диабетом требует особого внимания из-за повышенного риска развития заболеваний дыхательных путей, сердечно-сосудистой системы, головного мозга, почек, а также различных нарушений нутритивного статуса Цель: Изучить состояние физического развития и нутритивного статуса у детей, родившихся от матерей с различными нарушениями углеводного обмена Материалы и методы: 350 доношенных детей от матерей с сахарным диабетом, родившихся в родильном доме ГКБ им. Н. Э. Баумана. Оценка физического развития детей проводилась в соответствии со стандартами ВОЗ WHO Anthro (2006). Сравнительный анализ показателей детей в разных группах проводился с помощью T-критерия Стьюдента. Использовалась программа Statistica 10.Результаты: масса тела 350 обследованных новорожденных варьировала в пределах 1590-4710 г, в среднем составила 3421.1 ± 543.99 г. Было 67 (19,1%) детей с массой тела менее 3000 г и 46 (13,1%) более 4000 г. Значения роста 350 новорожденных составляли от 40 до 57 см, в среднем -51,21 ± 2,54 см. Были изучены показатели физического развития и проведен анализ во всех группах детей в зависимости от пола (массы тела (м), длины тела (Н), ИМТ; отношения массы тела к длине тела) в экспериментальной и контрольной группах.

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Section: таблицаunclassified

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Physical development of newborns born to mothers with different carbohydrate metabolism disorders

Харитонова¹,

Папышева²,

Богомаз³

et al. 2019

Eksp. Klin. Gastroenterol.

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show abstract

“…DM and its complications are among the leading causes of death in most countries -based on estimates, DM is responsible for 1 out of 12 adult deaths worldwide [1]. Obstetric history of gestational diabetes mellitus (GDM) is the major risk factor for the development of type 2 diabetes and metabolic syndrome among women [1,2].…”

Section: Introductionmentioning

confidence: 99%

Gestational and Previous Diabetes in Pregnancy: Perinatal Results

Ja¹,

Gqa²,

Pm³

et al. 2020

Asp Biomed Clin Case Rep

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Objective: Evaluating the association between gestational diabetes and fetal/maternal complications such as poor obstetric outcomes. Methods: Historical cohort comprising patients from the High-Risk Service of Federal University of Juiz de Fora (UFJF,) who were diagnosed with diabetes (exposed), as well as patients from the Low-Risk Service of UFJF (non-exposed). Data generated through anamnesis, physical examination and medical conduct, as well as data of newborns such as fetal weight, ICU admission and fetal/neonatal death), were collected and stored in the Epi Info software (version 6.0); p < 0.05. Results: 176 patients treated in the aforementioned services, 108 diabetic, and 68 non-diabetics, were investigated in the current study. In total, 92 (52.2%) of them were diagnosed with Gestational Diabetes Mellitus (GDM); 6 had DM type 1 (3.4%) and 10 had DM type 2 (5.6%). Therefore, 68 patients (38.6%) presented normal glucose metabolism. The mean age of the patients was 30.27 ± 6.77 years, the mean number of births was 1.06 ± 1.20. Macrosomia was diagnosed in 6.81% (n = 6) of the cases; it was associated with maternal glycemia (p < 0.05). D- and F-class pregnant women, who had been previously diagnosed with diabetes, presented lower fetal weight than other pregnant women (p = 0.03). Treatment was based on diet, insulin or metformin, whenever necessary. Fasting glycemia levels decreased throughout the gestational trimesters. Eighteen (10.2%) preterm fetuses were identified; 12 were born from diabetic mothers and 6 were born from non-diabetic ones (p = 0.01; X2 = 10.51). All infants hospitalized in the neonatal ICU (n = 10) were born from diabetic mothers; their mean gestational age was 36.28 + 2.9 weeks, whereas the mean gestational age of infants who were not hospitalized in the ICU was 38.31 ± 1.5 (p = 0.005; T = 12.58). Cesarean section was the most common way of delivery adopted for diabetic pregnant women (p = 0.04). Conclusion: Based on the results, gestational diabetes (GDM) is a predisposing factor to fetal macrosomia, prematurity, and hospitalization in neonatal ICUs. Pregnant women subjected to proper glycemic control in the current study presented lower complication rates in comparison to other studies in the literature.

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“…7 Quanto aos fatores de risco para o desenvolvimento da doença, citam-se: idade (35 anos ou mais), sobrepeso, obesidade ou ganho excessivo de peso na gravidez atual, deposição central exclusiva de gordura corporal, história familiar de diabetes em parentes de primeiro grau, crescimento fetal excessivo, polidrâmnio, hipertensão ou pré-eclâmpsia na gravidez atual, antecedentes obstétricos de abortamento de repetição, malformações, morte fetal ou neonatal, macrossomia, síndrome de ovários policísticos e baixa estatura (menos de 1,5m). [8][9][10] O Ministério da Saúde recomenda que as gestantes cumpram o mínimo de seis consultas de pré-natal, nas quais o profissional de saúde deve realizar o acompanhamento e a evolução da gestação, com a avaliação do estado nutricional da mulher prévio à gestação e no momento da consultautilizando o índice de massa corporal e, também, o índice de massa corporal, segundo a idade gestacionalobtidos através de medidas de peso e estatura, e a partir destes, faça a orientação dietética de acordo com as necessidades de cada gestante. 11 Mulheres que apresentam o estado nutricional inadequado, ou seja, baixo peso ou sobrepeso ou obesidade, estão mais susceptíveis a comorbidades durante a gestação, tais como o diabetes mellitus gestacional e a síndrome hipertensiva específica da gestação 12 , e no caso do diabetes, mulheres que apresentaram a doença durante a gestação.…”

Section: Introductionunclassified

Diabetes Gestacional e estado nutricional materno em um hospital universitário de Niterói

Guerra¹,

Alves²,

Rodrigues³

et al. 2018

J Nurs Health

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Objetivo: identificar o número de casos de diabetes gestacional e correlacionar estado nutricional pré-gestacional e diabetes mellitus gestacional em mulheres atendidas no ambulatório de Ginecologia e Obstetrícia de um Hospital Universitário em Niterói, Brasil. Método: transversal, analítico e retrospectivo. Pesquisa realizada em prontuários de mulheres assistidas durante o parto no ano de 2013, que realizaram no mínimo uma consulta de pré-natal na unidade. As análises estatísticas foram realizadas com o software estatístico Stata 20.0, considerando nível de significância de 5%. Aprovado pelo Comitê de ética em pesquisa sob parecer 1.354.164/2015. Resultados: 14% (n=25) desenvolveram diabetes gestacional; 24% iniciaram a gestação com sobrepeso e 29,5%, com obesidade. Conclusão: estudos que evidenciam o número de casos do diabetes gestacional a associação a fatores de risco, são importantes, principalmente para melhoria da assistência prestada e elaboração de novas estratégias de cuidado.

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Clinical characteristics of women with gestational diabetes - comparison of two cohorts enrolled 20 years apart in southern Brazil

Cited by 16 publications

References 24 publications

Physical development of newborns born to mothers with different carbohydrate metabolism disorders

Physical development of newborns born to mothers with different carbohydrate metabolism disorders

Gestational and Previous Diabetes in Pregnancy: Perinatal Results

Diabetes Gestacional e estado nutricional materno em um hospital universitário de Niterói

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