Chronic kidney disease - determinants of progression and cardiovascular risk. PROGREDIR cohort study: design and methods

Domingos, Maria Alice Muniz; Goulart, Alessandra Carvalho; Lotufo, Paulo A; Benseñor, Isabela Judith Martins; Titan, Silvia Maria de Oliveira

doi:10.1590/1516-3180.2016.0272261116

Cited by 11 publications

(11 citation statements)

References 25 publications

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“…Details of the methods have been published elsewhere. 9 Briefly, patients attending the outpatient service of Hospital das Clínicas, São Paulo, a quaternary-level care facility, were invited to participate in the study.…”

Section: Methodsmentioning

confidence: 99%

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Dietary intake of non-dialysis chronic kidney disease patients: the PROGREDIR study. A cross-sectional study

et al. 2018

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Section: Methodsmentioning

confidence: 99%

“…7 PROGREDIR is a cohort study that was designed to evaluate the determinants of CKD progression and mortality risk among CKD patients. 9 The cohort essentially comprises people with CKD classes 3…”

Section: Introductionmentioning

confidence: 99%

Dietary intake of non-dialysis chronic kidney disease patients: the PROGREDIR study. A cross-sectional study

et al. 2018

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“…When the FFQ used by Lew et al [ 11 ] was validated, energy and de-attenuated CC for nutrients ranged from 0.24 to 0.79 [ 58 ]. The SFFQ used by Domingos et al [ 16 ] had ICC in the validation study that ranged between 0.17 (selenium) to 0.66 (calcium) [ 59 ]. Reproducibility results of the FFQ used by Diaz-Lopez et al [ 13 ] were slightly higher than ours [ 57 ], but participants were specifically asked not to modify their dietary habits during the study’s 1-year duration.…”

Section: Discussionmentioning

confidence: 99%

“…Food Frequency Questionnaires (FFQs) have been previously developed in the CKD context but most of them are long questionnaires (around 150 items) [ 1 , 10 – 13 ] or focus on the estimation of specific nutrient/food intakes [ 14 , 15 ]. One SFFQ of 76 food items was developed in the Brazilian context [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Validity and reproducibility of a short food frequency questionnaire among patients with chronic kidney disease

et al. 2017

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BackgroundA balanced diet is essential to slowing the progression of chronic kidney disease (CKD) and managing the symptoms. Currently, no tool is available to easily and quickly assess energy and macronutrient intake in patients with non end-stage CKD.We aimed to develop and evaluate the validity and reproducibility of a new short 49-item food frequency questionnaire (SFFQ) adapted to patients with CKD.MethodsThe CKD-REIN study is a prospective cohort that enrolled 3033 patients with moderate or advanced CKD from a national sample of nephrology clinics. A sub-sample of 201 patients completed the SFFQ twice, at a one-year interval and were included in the reproducibility study. During this interval, 127 patients also completed six 24-h recalls and were included in the validity study. Main nutrient and dietary intakes were computed. Validity was evaluated by calculating crude, energy-adjusted and de-attenuated correlation coefficients (CC) between FFQ and the mean of the 24-h recall results. Bland-Altman plots were performed and cross-classification into quintiles of consumption of each nutrient and food group was computed. Reproducibility between the two SFFQs was evaluated by intraclass CC (ICC).ResultsRegarding validity, CC ranged from 0.05 to 0.79 (unadjusted CC, median: 0.40) and 0.10 to 0.59 (de-attenuated CC, median: 0.35) for food group and nutrient intakes, respectively. Five of the most important nutrients of interest in CKD, i.e. protein, calcium, phosphorus, potassium, and sodium had de-attenuated CC of 0.46, 0.43, 0.39, 0.32, and 0.12, respectively. The median of classification into the same or adjacent quintiles was 68% and 65% for food and nutrient intakes, respectively, and ranged from 63% to 69% for the five nutrients mentioned before. Bland-Altman plots showed good agreement across the range of intakes. ICC ranged from 0.18 to 0.66 (median: 0.46).ConclusionsThe CKD-REIN SFFQ showed acceptable validity and reproducibility in a sample of patients with CKD, notably for CKD nutrients of importance. It can now be used in large-scale epidemiological studies to easily assess the relations between diet and CKD outcomes as well as in clinical routine. It may also serve as a basis for the development of FFQs in international CKD cohort networks.Electronic supplementary materialThe online version of this article (10.1186/s12882-017-0695-2) contains supplementary material, which is available to authorized users.

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“…The PROGREDIR study is a cohort set in São Paulo, Brazil, comprising essentially participants with CKD classes 3 and 4 who are participating in ongoing follow-up [ 27 ]. This study aimed to evaluate cross-sectionally the association between macro- and micronutrient intakes, via a food frequency questionnaire (FFQ) and baseline coronary artery calcification (CAC), in this population.…”

Section: Introductionmentioning

confidence: 99%

Association between Dietary Intake and Coronary Artery Calcification in Non-Dialysis Chronic Kidney Disease: The PROGREDIR Study

et al. 2018

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Coronary artery calcification (CAC) is a widespread condition in chronic kidney disease (CKD). Diet may play an important role in CAC, but this role is not clear. This study evaluated the association between macro-and micronutrient intakes and CAC in non-dialysis CKD patients. We analyzed the baseline data from 454 participants of the PROGREDIR study. Dietary intake was evaluated by a food frequency questionnaire. CAC was measured by computed tomography. After exclusion of participants with a coronary stent, 373 people remained for the analyses. The highest tertile of CAC was directly associated with the intake of phosphorus, calcium and magnesium. There was a higher intake of pantothenic acid and potassium in the second tertile. After adjustments for confounding variables, the intake of pantothenic acid, phosphorus, calcium and potassium remained associated with CAC in the generalized linear mixed models. In order to handle the collinearity between these nutrients, we used the LASSO (least absolute shrinkage and selection operator) regression to evaluate the nutrients associated with CAC variability. In this approach, the nutrients that most explained the variance of CAC were phosphorus, calcium and potassium. Prospective studies are needed to confirm these findings and assess the role of interventions regarding these micronutrients on CAC prevention and progression.

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Chronic kidney disease - determinants of progression and cardiovascular risk. PROGREDIR cohort study: design and methods

Abstract: The PROGREDIR cohort is a promising prospective study that will allow better understanding of CKD determinants and validation of candidate biomarkers for the risks of CKD progression and mortality.

Cited by 11 publications

References 25 publications

Dietary intake of non-dialysis chronic kidney disease patients: the PROGREDIR study. A cross-sectional study

Dietary intake of non-dialysis chronic kidney disease patients: the PROGREDIR study. A cross-sectional study

Validity and reproducibility of a short food frequency questionnaire among patients with chronic kidney disease

Association between Dietary Intake and Coronary Artery Calcification in Non-Dialysis Chronic Kidney Disease: The PROGREDIR Study

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