Vacina como agente de imunização contra o HPV

Abstract

vacina como agente de imunização contra o HPvVaccines as an agent for immunization against HPV

Knowledge and attitudes about human papillomavirus and vaccination

“…5, 21 However, the use of condoms, male and female, must no be forgotten, as another resource in the fight against infection, as mentioned by the participants. Even partially protecting against contamination, due to the possibility of contact with lesions that may be discovered, until then it is considered an important ally to avoid the contagion during intercourse with penetration.…”

Papilomavírus Humano: Prevenção E Diagnóstico

“…Podendo desta forma ser transmitido durante o parto, devido contato da região genital, ressalta-se que algumas mulheres infectadas por HPV, não possuem sintomas (assintomática), o que dificulta o diagnóstico precoce, que evita ou retarda a progressão para o câncer invasivo, que pode ocorrer em qualquer idade. 6,11,25 Em relação ao HPV de alto risco, que se integra no núcleo celular, se mantendo forma de epissomo, o mesmo amplia o genoma viral em milhões de cópias por célula, independente do genoma da célula hospedeira, assim, gradativamente evolui para um câncer de colo de útero, em contrapartida, as infecções por HPV de baixo risco, a paciente desenvolve condilomas e verrugas, acrescentando que as infecções em locais não genitais, incluindo a boca, orofaringe são raras, porém ocorre mais em crianças, caracterizando um modo não sexual de transmissão.…”

Estratégia de vacinação contra HPV

“…HPV is associated with cervical cancer, one of the major public health problems responsible for female deaths. 1 According to data from the World Health Organization (WHO) 2 , cervical cancer is the second most common cancer in women living in less developed regions, after breast cancer. In 2012, a total of 445,000 new cases per year were estimated in these regions, accounting for 84% of new cases worldwide.…”

“…Other HPVrelated neoplasms, such as the vulva, vagina, and anus, are also at increased risk with age in women previously infected with the virus. 1 Vaccination is an effective and costeffective method to combat a disease of infectious etiology. 3 In 2006, the Food and Drug Administration (FDA) approved the quadrivalent vaccine as an immunizing agent against HPV 4 , and in that same year National Agency of Sanitary Surveillance of Brazil (Anvisa) regulated the commercialization of this vaccine.…”

“…1,20 It has been proven in other countries that the HPV vaccine (HPV-B and HPV-Q) prevents cervical cancer and other HPV-related cancers with moderate to high efficacy. Also, Brazil…”