Bioactive glass in cavitary bone defects: a comparative experimental study in rabbits

Abstract

OBJECTIVES: To compare bioactive glass and autograft regarding their histomorphometric characteristics. METHODS: The authors conducted a prospective case-control experimental study on animals in order to compare the histomorphometric characteristics of bioactive glass versus autograft. Eight rabbits underwent surgery in which a cavitary defect was created in both proximal femurs. One side was filled with bioactive glass granules and the other, with autograft grafted from the contralateral side. The sides were randomized. Fourteen days after surgery, the animals were euthanized. RESULTS: Histologic analysis revealed that bone neoformation was equivalent among the two groups and the osteoblasts cell-count was higher in the femurs treated with bioactive glass. The osteocytes cell-count, however, was lower. The similarity in bone formation between both groups was consistent to literature findings. CONCLUSION: Bioactive glass is similar to autograft regarding bone neoformation in this animal model of cavitary bone defects. Level of Evidence III, Case-Control Study.

Effect of S53P4 bioactive glass and low-level laser therapy on calvarial bone repair in rats submitted to zoledronic acid therapy

“…The bioactive material is composed of several ionic compounds (SiO 2 , Na 2 O, CaO, P 2 O 5 ) which when implanted to the receptor surface releases alkaline ions, cause an abrupt pH increase, thus allowing inhibition of bacterial growth through osmotic and acid-base imbalance generated in the local, not being dependent on local antibiotics applications 39,40 . The osteoconductive capacity of bioactive glass has been demonstrated in several previous scientific studies (Table 2) [41][42][43][44][45][46][47][48] , which is consistent with our research data, since it was observed a statistically significant difference in bone neoformation after 14-day and 28-day period in the groups filled with the bioactive glass (submitted or not to PBMT) when compared with the control group AZC. Glass granules can only conduct bone growth efficiently, as long as a direct contact between the glass and the bone can be achieved.…”

Injectable bioactive glass-based pastes for potential use in bone tissue repair

“…The following histological scoring scale for the presence and intensity of bone formation was used for statistical analysis [29,30]: 1. no osteogenesis, 2. weak osteogenesis, 3. medium-low osteogenesis, 4 medium-high osteogenesis, 5. good-low osteogenesis, 6. good-high osteogenesis, 7. perfect osteogenesis. For this purpose, each slide of histopathological sections was divided into four segments to be observed in detail while the average of the scores of the four quadrants represents the score given to the slide [29].…”

“…Since there were two groups -one was the control and the other was the experimental one treated with BG-gly paste, statistical analysis was performed by using Wilcoxon-Mann-Whitney test [29]. The tests were performed with a level of significance of 5%.…”

Osteomyelitis: Recent advances in pathophysiology and therapeutic strategies

“…Preliminary human studies have demonstrated promising results. [76][77][78][79] The current understanding of the differences in biological properties between non-absorbable PMMA and absorbable biomaterials for treatment of PJI is summarized in Fig. 2.…”