Effect of S53P4 bioactive glass and low-level laser therapy on calvarial bone repair in rats submitted to zoledronic acid therapy

Abstract

To evaluate the influence of bioactive glass and photobiomodulation therapy (PBMT) in calvarial bone repair process in rats submitted to zoledronic acid therapy. Methods: Twenty-four rats were selected and treated with the dose of 0.035 mg/kg of zoledronic acid every two weeks, totalizing eight weeks, to induce osteonecrosis. After the drug therapy, surgical procedure was performed to create 5-mm diameter parietal bone defects in the calvarial region. The rats were then randomly assigned to groups according to the following treatments: AZC: control group, treated with blood clot;

The additive effects of bioactive glasses and photobiomodulation on enhancing bone regeneration

“…Recently, some studies combined biomaterials with PBM and have achieved positive results in tissue regeneration [ 48–50 ]. However, some other studies showed that the superiority of PBM cannot be exploited when combined with biomaterials, which may be related to the excessive stimulation of tissue caused by the inappropriate dosage of biomaterials and PBM [ 51 ].…”

The additive effects of photobiomodulation and bioactive glasses on enhancing early angiogenesis

“…In recent years, some studies have combined PBM and biomaterials to observe their effects on wound healing and tissue regeneration. Several studies achieved good results and found that PBM improved bone repair process together with biomaterials [20][21][22][23]. In other studies, however, the combination of PBM and biomaterials did not show the expected effects of promoting tissue regeneration [24][25][26][27].…”