Thymomodulin in association with antifungal drugs in the therapy of cats with disseminated cutaneous sporotrichosis: a prospective study

Abstract

Feline sporotrichosis is a relevant mycose in veterinary medicine due to its severity and zoonotic potential and the fact that it can be difficult to treat. The immune status of the animal exerts influence on the prognosis of the disease and determines its clinical outcome. This study evaluated the efficacy of the immunomodulatory thymomodulin as an adjunct to antifungal therapy in cats with disseminated sporotrichosis; thymomodulin was used in association with itraconazole (ITL) and potassium iodide (KI) to treat this fungal disease in the feline patient. Thirty-one cats (n=31) diagnosed with disseminated cutaneous sporotrichosis were divided into two groups as follows: Group 1 (G1) (n=16), which included those animals that were treated with thymomodulin in association with ITL and KI, and Group 2 (G2) (n=15) which had pacientsthat received ITL and KI only. The response to different treatment modalities was assessed, considering the survival rate, time frame for the lesions to respond to therapy, and clinical improvement or deterioration according to a body condition score system. Animals from G1 had a survival rate of nearly 100% (93.6%) that was approximately twice higher than the survival rate of those animals from G2 (53%). Moreover, patients from G1 had a significantly better prognosis, improved body condition, and shorter time for remission of the extra cutaneous clinical signs (p<0.02). Our findings showed that the association of thymomodulin with ITL and KI improves the prognosis of cats with disseminated cutaneous sporotrichosis.

Feline sporotrichosis: Review

“…Sendo o G1, felinos tratados com itraconazol, iodeto de potássio associada à timomodulina e o grupo G2 somente itraconazol e iodeto de potássio. Os resultados constataram que os gatos do G1 apresentaram maior taxa de sobrevivência e aprimoramento do escore de condição corporal, em comparação com os felinos do G2 (Forlani et al, 2021). Vale enfatizar, que o prognóstico está diretamente relacionado aos fatores de patogenicidade do agente etiológico, pacientes imunocompetentes, período longo ou curto para o diagnóstico definitivo e se a abordagem terapêutica foi seguida pela orientação do médico veterinário (Cavalcanti et al, 2018).…”