In vitro screening for growth inhibition activity on cancer cell lines of northern Chile highlands shrubs

González, Luis Bustos; Simirgiotis, Mario J.; Parra, Claudio; Alfaro-Lira, Susana; Soto, Emilio; Echiburú-Chau, Carlos

doi:10.1590/0103-8478cr20190757

Cited by 3 publications

(1 citation statement)

References 23 publications

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“…Lutein is recognized for its anti-inflammatory and antioxidant properties [25]. The different concentrations of the compounds identified in this species depend on multiple factors, such as different extraction methods and experimental protocols and harvest time, growth stage, altitude, and climate [37]. In this context, the unique characteristics of the Cape gooseberry produced in this desertic growing area make the fruit an important natural source of phenolic compounds, as was proven for other species cultivated in desertic extreme habitats [38].…”

Section: Chemical Compositionmentioning

confidence: 99%

Chemical Characterization, Nutritional and Bioactive Properties of Physalis peruviana Fruit from High Areas of the Atacama Desert

Muñoz

Parra

Simirgiotis

et al. 2021

Foods

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Physalis peruviana L. belongs to the Solanaceae family and produces a spherical fruit used to treat various diseases. However, the chemical composition, nutritional characterization, and bioactive properties of the P. peruviana growing in the Andean region of the Atacama Desert have not been conducted so far. The results showed clear differences in the nutritional and bioactive characteristics of the fruits grown in arid environmental conditions, which were comparable to those from countries with a production tradition. The fruits studied showed a higher Ca, Cu, Mn, P, and Zn content and bioactive compounds such as flavonoids and tannins than those reported in the literature. UHPLC was performed to determine the main phenols. Gallic acid was identified as the predominant phenolic compound in this species (303.63 mg/100 g FW), of which to our knowledge no previous study has reported similar concentrations in this species. Moreover, Cape gooseberry extract has antioxidant and antimicrobial activity against Gram-positive and Gram-negative bacteria. Pseudomonas syringae (MIC 0.313 mg/mL and MBC 1.25 mg/mL) was the most susceptible bacterium. Meanwhile, Erwinia rhapontici was the most resistant bacterium (MIC and MIB 5.00 mg/mL). Furthermore, it was found to inhibit α-amylase activity with an IC50 value (39.28 µg/mL) similar to that of acarbose (35.74 µg/mL). These results expand the knowledge of the species cultivated in arid environmental conditions and suggest an alternative for the potential use of this fruit to manage chronic diseases such as diabetes.

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Section: Chemical Compositionmentioning

confidence: 99%

Chemical Characterization, Nutritional and Bioactive Properties of Physalis peruviana Fruit from High Areas of the Atacama Desert

Muñoz

Parra

Simirgiotis

et al. 2021

Foods

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Impacts of the Use of Brazilian Fauna and Flora in Food and Medicinal Use

Da Costa,

Araújo,

Carvalho

et al. 2023

RGSA

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Objective: To describe the main repercussions of the use of Brazilian fauna and flora for food and medicinal purposes. Method: This is an integrative literature review with a descriptive and qualitative approach. Searches were conducted in the Virtual Health Library system of the Ministry of Health using the following descriptors: medicinal teas, phytotherapeutic medication, and medicinal plants. Initially, 415 results were found without filters, and after applying the filters, the number of studies reduced to 74. From these, the titles from the database search were read, resulting in a final sample of only 15 articles for qualitative synthesis. Results and conclusion: Through the conducted searches, it was found that the use of plants as medicines dates back to prehistoric times when humans began to utilize nature to cure their illnesses. Currently, medicinal plants are widely used in different parts of the world and are important sources of new bioactive molecules that can be used in the development of new medicines, dietary supplements, and natural cosmetics. Research implications: The study highlights the richness and diversity of Brazilian flora, emphasizing the importance of preserving these natural resources. This is crucial for the conservation of unique plant and animal species in Brazil. Originality/value: The study emphasizes the need for policies for the preservation and sustainable use of Brazilian fauna and flora resources. This is essential to ensure the survival of these species and to provide safe and effective treatments for people.

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UHPLC-DAD Characterization of Origanum vulgare L. from Atacama Desert Andean Region and Antioxidant, Antibacterial and Enzyme Inhibition Activities

et al. 2021

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The Lamiaceae family is an important source of species among medicinal plants highly valued for their biological properties and numerous uses in folk medicine. Origanum is one of the main genera that belong to this family. The purpose of the study was to determine the phenolic composition of the Origanum vulgare extract and evaluate the antimicrobial, antioxidant, and inhibitory activities of this species that grows in the Andean region of the Atacama Desert. High-performance liquid chromatography was performed to determine the main phenols. Rosmarinic acid was identified as the predominant phenolic compound in this species (76.01 mg/100 g DW), followed by protocatechuic acid, which to our knowledge, no previous study reported similar concentrations in O. vulgare. The oregano extract exhibited a content of total phenolic (3948 mg GAE/100 g DW) and total flavonoid (593 mg QE/100 g DW) with a higher DPPH antioxidant activity (IC50 = 40.58 µg/mL), compared to the same species grown under other conditions. Furthermore, it was found to inhibit α-glucosidase activity with an IC50 value (7.11 mg/mL) lower than acarbose (129.32 mg/mL). Pseudomonas syringae and Pantoea agglomerans (both MIC 0.313 mg/mL and MBC 1.25 mg/mL) were the bacteria most susceptible to oregano extract with the lowest concentration necessary to inhibit bacterial growth. These results open the door for the potential use of this plant to manage chronic diseases, and they expand the knowledge of the species cultivated in arid environmental conditions.

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In vitro screening for growth inhibition activity on cancer cell lines of northern Chile highlands shrubs

Cited by 3 publications

References 23 publications

Chemical Characterization, Nutritional and Bioactive Properties of Physalis peruviana Fruit from High Areas of the Atacama Desert

Chemical Characterization, Nutritional and Bioactive Properties of Physalis peruviana Fruit from High Areas of the Atacama Desert

Impacts of the Use of Brazilian Fauna and Flora in Food and Medicinal Use

UHPLC-DAD Characterization of Origanum vulgare L. from Atacama Desert Andean Region and Antioxidant, Antibacterial and Enzyme Inhibition Activities

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