Detection of serum amyloid-A concentration in the calf clinically diagnosed with pneumonia, enteritis and pneumoenteritis

Kabu, Mustafa; Elitok, Bülent; Küçükkurt, İ̇smail

doi:10.1590/0103-8478cr20150571

Cited by 8 publications

(7 citation statements)

References 24 publications

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“…In veterinary medicine, SAA is considered the major APP in horses and one of the major APPs in cattle and pigs (Hulten and Demmers, 2002; Pradeep, 2014). Its concentration rises in experimental and natural infections of different natures (Campbell et al ., 2005; Kabu et al ., 2016; Joshi et al ., 2018), including viral infections (Heegaard et al ., 2000; Sánchez-cordón et al ., 2007) and other conditions such as local aseptic inflammation, traumatic reticuloperitonitis, non-infectious diarrhea, or surgery (Nunokawa et al ., 1993; Jacobson et al ., 2001; Parra et al ., 2006; Pourjafar et al ., 2011; Baydar and Dabak, 2014). In some of these cases, SAA can remain high for some time after the trigger has disappeared (Aitken et al ., 2019).…”

Section: Traditional Biomarkers Of Sepsismentioning

confidence: 99%

Biomarkers of sepsis in pigs, horses and cattle: from acute phase proteins to procalcitonin

López-Martínez

Franco‐Martínez

Martínez-Subiela

et al. 2022

Anim. Health. Res. Rev.

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Sepsis is a complex clinical syndrome triggered by an inflammatory host response to an infection. It is usually complicated to detect and diagnose, and has severe consequences in human and veterinary health, especially when treatment is not started early. Therefore, efforts to detect sepsis accurately are needed. In addition, its proper diagnosis could reduce the misuse of antibiotics, which is essential fighting against antimicrobial resistance. This case is a particular issue in farm animals, as antibiotics have been traditionally given massively, but now they are becoming increasingly restricted. When sepsis is suspected in animals, the most frequently used biomarkers are acute phase proteins such as C-reactive protein, serum amyloid A and haptoglobin, but their concentrations can increase in other inflammatory conditions. In human patients, the most promising biomarkers to detect sepsis are currently procalcitonin and presepsin, and there is a wide range of other biomarkers under study. However, there is little information on the application of these biomarkers in veterinary species. This review aims to describe the general concepts of sepsis and the current knowledge about the biomarkers of sepsis in pigs, horses, and cattle and to discuss possible advances in the field.

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Section: Traditional Biomarkers Of Sepsismentioning

confidence: 99%

Biomarkers of sepsis in pigs, horses and cattle: from acute phase proteins to procalcitonin

López-Martínez

Franco‐Martínez

Martínez-Subiela

et al. 2022

Anim. Health. Res. Rev.

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“…In the other study, significant increases were observed in serum Hp and SAA concentrations in calves suspected from Bovine respiratory disease (10). Also significant increase in the SAA concentration had been observed in calves with enteritis and pneumonia compared to the control group (11). Coşkun et al (4) reported that SAA and Hp levels in both of the blood serum and the bronchoalveolar lavage were higher in calves with bronchopneumonia than in healthy calves.…”

Section: Discussionmentioning

confidence: 82%

Determination of serum amyloid A, haptoglobin and hepcidin levels in calves with endemic viral pneumonia

Dörtkardeş

Şahinduran

2020

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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The aim of this study was to investigate serum amyloid A, haptoglobin and hepcidin levels in respiratory infections caused by various viral agents in calves. Pneumonia is an infectious or non-infectious disease affecting the lungs of all animals, and during the inflammation, blood levels of acute phase proteins increase rapidly. Hepcidin is a hormone that has many functions and is known as type II acute phase reactant. The blood samples were collected from a total of 20 calves to form the study group. The control group consisted of 10 healthy animals. Sera were analyzed with ELISA for antigen detection. According to the results, Bovine herpesvirus type-1 (BHV-1) was positive in 3 calves, Bovine viral diarrhea virus (BVDV) was positive in 3 calves, Bovine respiratory syncytial virus (BRSV) was positive in 1 calf, and Bovine parainfluenza virus type 3 (BPI3) was positive in 1 calf. Adenovirus infection was detected in 5 animals together with other viruses. Mixed infections were observed in 12 calves. Haptoglobin, serum amyloid A and hepcidin values were measured in sera. According to the results, statistically significant differences were observed between the two groups for the haptoglobin (P<0.01), serum amyloid A (P<0.05) and hepcidin (P<0.05). It was concluded that these parameters can be used to support the diagnosis of respiratory infections of the calves.

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“…During rotavirus, coronavirus and E.coli infections, a significant increase in SAA concentrations as well as diarrhea were observed in calves (Balikci and Al 2014). In case of naturally occurring rotavirus or coronavirus coinfection with Cryptosporidium versus mono-infection, significantly higher SAA concentration increase has been previously reported (Eckersall et al, 2001;Kabu et al 2016). In a previous study Molina et al (2014) established that SAA concentration significantly increased in animals infected with bovine viral diarrhea virus.…”

Section: Resultsmentioning

confidence: 88%

Determining Serum Amyloid-A (SAA), Haptoglobin (Hp), Tumor Necrosis Factor (TNF-α) and Interleukins-1 (IL-1β) and 6 (IL-6) Levels in Neonatal Calves with Amoebiasis

Kabu

Koca

Sayber

2022

IJAR

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Background: Amoebiasis is a pathogen organism which is well-known both in human and veterinary medicine. The aim of this study was to determine serum amyloid-A (SAA), haptoglobin (Hp), tumor necrosis factor (TNF-α) and interleukins-1 (IL-1β) and 6 (IL-6) levels in neonatal calves which were naturally infected with amoebiasis. Methods: In the study, 40 one to four-week-old calves with amoebiasis which were clinically diagnosed with diarrhea and were non-responsive to the treatment, and 10 healthy calves were used. From the stool samples taken from the calves which were clinically diagnosed with diarrhea, Entamoeba histolytica was detected by using ELISA kit. Serum was obtained from the blood taken from vena jugularis from all calves. Concentrations of SAA, Hp, TNF-α, IL-1β and IL-6 in serum were measured in ELISA by using commercial kits. Also, some enzymes measurements were made from serum. Result: Concentrations of SAA, Hp, TNF-α, IL-1β and IL-6 in calves with amoebiasis were higher (p less than 0.05) in comparison to the control group. To conclude, amoebiasis led to an increase in the concentrations of SAA, Hp, TNF-α, IL-1β and IL-6 in neonatal calves. We suggest that this might have stemmed from the inflammatory response against amoebiasis.

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Detection of serum amyloid-A concentration in the calf clinically diagnosed with pneumonia, enteritis and pneumoenteritis

Cited by 8 publications

References 24 publications

Biomarkers of sepsis in pigs, horses and cattle: from acute phase proteins to procalcitonin

Biomarkers of sepsis in pigs, horses and cattle: from acute phase proteins to procalcitonin

Determination of serum amyloid A, haptoglobin and hepcidin levels in calves with endemic viral pneumonia

Determining Serum Amyloid-A (SAA), Haptoglobin (Hp), Tumor Necrosis Factor (TNF-α) and Interleukins-1 (IL-1β) and 6 (IL-6) Levels in Neonatal Calves with Amoebiasis

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