“…Acute or chronic exposure of fish to endosulfan can cause structural modifications to the gills and, with changes to the osmotic equilibrium, impair gas exchange, although it depends on the concentration (Capkin et al, 2006). Morphological changes in the liver may include the appearance of vacuolization of hepatocytes, glycogen depletion, alteration of capillary sinusoids, change in size of hepatocytes, and necrosis (Cengiz et al, 2001;Glover et al, 2007) which, according to some authors, may influence the synthesis of vitellogenin in the liver and the formation of vitellogenic follicles (Al-Ghais, 2013;Barni et al, 2014;Marcon et al, 2014Marcon et al, , 2015. Furthermore, hepatic physiology can be compromised differently depending on the period of exposure to pesticides, the concentration of the contaminant, and dietary habits (Ribeiro et al, 2006;Al-Ghais, 2013;Barni et al, 2014;Benze et al, 2014).…”