Changes in oxidative markers, endogenous antioxidants and activity of the enzyme acetylcholinesterase in farmers exposed to agricultural pesticides - a pilot study

Murussi, Camila; Horn, Roberta Cattaneo; Santi, Adriana; Clasen, Bárbara; Reis, Gabriel Lasmar dos; Souza, Daniela; Bortolotto, Josiane Woutheres; Manfio, Cândida Elisa; Loro, Vânia Lúcia

doi:10.1590/0103-8478cr20130516

Cited by 24 publications

(15 citation statements)

References 25 publications

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“…24 Furthermore, excess of body fat also affects the mitochondrial metabolism and promotes hyperleptinemia, thus favoring the occurrence of oxidative stress. [8][9][10] The formation of lipid peroxidation (LPO) products is one of the consequences from oxidative stress.…”

Section: Figurementioning

confidence: 99%

“…29 CPs are quickly formed and widely used as protein oxidative damage markers. 24,30 According to Uzun et al, 31 the excess of nutrients consumed by obese patients appears to contribute to ROS overproduction and, consequently, to oxidative stress occurrence. This explains the high CP levels in the pre-surgical obese group assessed in the current study, as well as the reduced protein damages after the surgery, since the patients had already shown weight loss by then.…”

Section: Figurementioning

confidence: 99%

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Obesity, bariatric surgery and oxidative stress

Horn

Gelatti

Mori

et al. 2017

Rev. Assoc. Med. Bras.

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Introduction: Obesity refers to the accumulation of fatty tissues and it favors the occurrence of oxidative stress. Alternatives that can contribute to body weight reduction have been investigated in order to reduce the production of reactive oxygen species responsible for tissue damage. The aim of the current study was to assess whether the oxidant and antioxidant markers of obese women before and after bariatric surgery were able to reduce oxidative damage. Method:We have assessed 16 morbidly obese women five days before and 180 days after the surgery. The control group comprised 16 non-obese women. Levels of thiobarbituric acid-reactive substances, carbonylated proteins, reduced glutathione and ascorbic acid were assessed in the patients' plasma. Results: Levels of lipid peroxidation and protein carbonylation in the pre-surgical obese women were higher than those of the controls and post-surgical obese women. Levels of reduced glutathione in the pre-surgical obese women were high compared to the controls, and declined after surgery. Levels of ascorbic acid fell in the pre--surgical obese women compared to the control and post-surgical obese women. Conclusion: Body weight influences the production of reactive oxygen species. Bariatric surgery, combined with weight loss and vitamin supplementation, reduces cellular oxidation, thus reducing tissue damage.

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Section: Figurementioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Obesity, bariatric surgery and oxidative stress

Horn

Gelatti

Mori

et al. 2017

Rev. Assoc. Med. Bras.

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“…Herbicides are agrochemicals used for controling the growth of harmful, undesirable weeds, and they are intended to significantly increase crop yields (Murussi et al, 2014). Most of such compounds are little molecules that normally do not cause intrinsic toxic effects.…”

Section: Introductionmentioning

confidence: 99%

Research on the Effect of Antioxidant Tabernaemontana catharinensis (Apocynaceae) on Erythrocytes Exposed to the Herbicide 2,4-Dichlorophenoxyacetic Acid

Horn¹,

Junges²,

Magni³

et al. 2016

JAS

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With the purpose of finding an alternative to mitigate the damaging effect of intoxication with 2,4-D (2,4-Dichlorophenoxyacetic acid), this research aims to determine whether Tabernaemontana catharinensis (cobrina) increases the antioxidant capacity and/or lowers the oxidative effects generated by the exposure to this herbicide. For the above purpose, blood samples were obtained from healthy volunteers. The erythrocytes were separated, exposed to the 2,4-D and treated with different concentrations of infusions of cobrina. Tests were conducted in a water bath at 37 °C for one hour. After the analytical determinations, it was verified that, with the duration of this test, the cobrina -even containing flavonoids in its composition-increased the oxidative damages in the proteins and lipids of the erythrocytes tested.

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“…Being the result of one from three factors: (1) Increase in the generation of EROs and/or of nitrogen (ERNs), through the accumulation of reactive intermediaries; (2) Prejudice of the antioxidant defense system (inhibition of antioxidant enzymes, depletion of non-enzymatic antioxidants); (3) Incapability to repair oxidative damage (Araújo, 2002). Considering that, increase in ERs or the antioxidant system of the body deficiency lead to the development of oxidative stress that can damage lipids, proteins or DNA (Murussi et al, 2014). The antioxidant system of the organism can be divided into enzymatic and non-enzymatic.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Effect of Physalis Peruviana Fruit Aqueous Extract − The Antioxidant Effect of Physalis

Horn¹,

Soares²,

Mori³

et al. 2015

JAS

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The acid 2,4-dichlorophenoxyacetic (2,4-D), agrochemical widely applied to the improvement of the agricultural productivity, is recognized as extremely toxic, once that its effects are accompanied by the occurrence of oxidative stress. On this context it becomes fundamental to explore components that are able to reduce the damages caused to the organism by this pesticide. The P. Peruviana, is a plant known that it presents components which contribute to the neutralization of the reactive species. Thus, this study had as purpose to evaluate the effect of P. Peruviana fruit aqueous extract on the bio-markers of oxidative stress in erythrocytes exposed to the 2,4-D. The exposition of samples to the 2,4-D has been done, followed to the treatment of these ones with different concentrations of the P. Peruviana Extract (1; 10; 25; 50 e 83 g/L). The results show an increase of the TBARS, PCs, and GSH after the exposure to the 2,4-D. On the other hand, after the treatment of the samples there was a reduction of the PCs and GSH levels in all the treated groups, and a decrease of the lipid peroxidation levels on the groups that were exposed to the Extract on the concentrations of 1 and 10g/L. The results show that the P. Peruviana owns an effect on the antioxidant system of the organism, viewing that it stimulated the consumption of GSH and thus it was able to fix damages in lipids and proteins provoked by 2,4-D specially on the concentrations of 1 and 10 g/L.

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Changes in oxidative markers, endogenous antioxidants and activity of the enzyme acetylcholinesterase in farmers exposed to agricultural pesticides - a pilot study

Abstract: Agricultural practices are directly related to the use of pesticides, which indiscriminately and without due care may contribute to the occurrence of numerous intoxications. Several studies have demonstrated the relationship of certain pesticides

Cited by 24 publications

References 25 publications

Obesity, bariatric surgery and oxidative stress

Obesity, bariatric surgery and oxidative stress

Research on the Effect of Antioxidant Tabernaemontana catharinensis (Apocynaceae) on Erythrocytes Exposed to the Herbicide 2,4-Dichlorophenoxyacetic Acid

Antioxidant Effect of Physalis Peruviana Fruit Aqueous Extract − The Antioxidant Effect of Physalis

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