Oral Nodular Lesions in Patients with Sjögren’s Syndrome: Unusual Oral Implications of a Systemic Disorder

Pinheiro, Juliana Barchelli; Tirapelli, Camila; Silva‐Lovato, Cláudia Helena; Komesu, Marilena Chinali; Petean, Flávio Calil; Louzada‐Júnior, Paulo; León, Jorge Esquiche

doi:10.1590/0103-6440201601013

Cited by 4 publications

(5 citation statements)

References 13 publications

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“…However, there were no reports with MRI findings of the submandibular or sublingual glands in patients with SS pertaining to the retention of saliva. However, two case reports of three cases of ranula similar to our cases were found (Katayama et al, ; Pinheiro et al, ).…”

Section: Discussionsupporting

confidence: 84%

“…All of the cases presented with undiagnosed SS at the initial examination. MRI was performed to determine the extent of the lesions and complications of neoplastic lesions, and the findings led (Katayama et al, 1993;Pinheiro et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…No studies pertaining to SS and MRI findings of the submandibular and sublingual gland regions were found (#1). However, three cases in two case reports (Katayama, Yamazaki, & Nishioka, 1993;Pinheiro et al, 2017) of mucocele of the floor of the mouth with concomitant SS were found (#2).…”

Section: Liter Ature Re Vie Wmentioning

confidence: 99%

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Sjögren’s syndrome and ranula development

et al. 2019

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Objectives We hypothesized that the extravasation of saliva from damaged ducts with lymphocytic infiltration in patients with Sjögren's syndrome causes ranulas. There are too many uncertainties to support this hypothesis. The aim of this study was to investigate whether there is an association between Sjögren's syndrome and ranulas. Materials and Methods We observed three cases of patients with ranulas who were also diagnosed with Sjögren's syndrome at the same facility. These cases led to the question of whether there are other such cases, and thus, an exhaustive literature search was conducted. Results Three cases in two case reports of mucocele of the floor of the mouth associated with adult Sjögren's syndrome were noted. Including our cases, until now, there have been six cases of ranula with adult Sjögren's syndrome. Conclusions It could be useful to investigate whether patients presenting with a ranula are also affected by Sjögren's syndrome and, conversely, investigate patients with Sjögren's syndrome longitudinally to see whether they develop ranulas.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

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Sjögren’s syndrome and ranula development

et al. 2019

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“…Similarly, Pinheiro JB et al . described a 37 years old woman presenting a single mucocele on the floor of the mouth 12 months after SS initial diagnosis ( 17 ). It is important to highlight that none of such cases were considered SM.…”

Section: Discussionmentioning

confidence: 99%

Superficial mucoceles in cancer patients: a retrospective series from a Stomatology unit

Heguedusch

Tomo²,

Almeida³

et al. 2020

Med Oral

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Background The aim of this study is to relate all the superficial mucoceles found in a cancer center, described the association with oncological conditions, and discuss its etiology and pathology that we found in the past few years. Material and Methods Sixteen cases of superficial mucocele were retrieved from the patients’ records of the Stomatology Department of the A. C. Camargo Cancer Center, São Paulo, Brazil, and demographic and clinical data were collected from electronic medical records. Results There were 16 patients, 8 patients were men and 8 women, with ages varying from 26 to 70 years old. Superficial mucoceles were observed in patients submitted to head and neck radiotherapy ( n =6), graft versus host disease ( n =4), one associated with oral mucositis related to allogenic bone marrow stem cells transplantation ( n =1), systemic lupus ( n =1), Sjögren’s syndrome ( n =1), oral lichenoid lesion associated with pembrolizumab ( n =1) and no local or systemic inflammatory associated found ( n =2). Conclusions This study reports a series of superficial mucoceles from a single stomatology unit. Most patients had superficial mucoceles secondary to head and neck radiotherapy and graft versus host diseases. However, two patients (12.5%) had mucoceles related to systemic inflammatory conditions (Sjögren’s Syndrome and Systemic Lupus). Key words: Superficial mucocele, oncological treatment, oral lesions.

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“…Tylko u 3 pacjentów ranule wykryto po rozpoznaniu pSS. Wyniki te sugerują, że ranule mogą być wczesnymi objawami klinicznymi pSS [12,13].…”

Section: Ranula a Zespół Sjögrenaunclassified

Ranula as an early symptom of Sjögren’s syndrome

Aleksandrowicz

Zielińska

Zarankiewicz

et al. 2022

J Educ Health Sport

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Introduction and purpose: Sjögren's syndrome is an autoimmune disease affecting exocrine glands, mainly salivary glands. A ranula is a type of retention cyst associated with salivary extravasation that develops within the large salivary glands. The most common reason of developing ranula is trauma of bottom of the oral cavity. Damaging the sublingual gland, due to changes in Sjögren’s syndrome, may lead to the development of ranula. The aim of this review is to analyze the possible impact of ranulas on early diagnosis of Sjögren's syndrome. Material and method: This review was based on articles collected in PubMed and published in the years 2003-2021 and books from 2009 and 2018. Articles were chosen using keywords such as "Sjögren's syndrome", "ranula", “mucocele” and "early diagnosis". Results: Ranulas are considered to be early clinical signs of Sjögren's syndrome. Undergoing diagnostic imaging in patients with ranulas allows to diagnose Sjögren's syndrome in early stage and implement appropriate therapy. Conclusion: Identification of ranula should suggest implementation of diagnostics of Sjögren's syndrome using imaging methods such as magnetic resonance imaging or ultrasonography. Early diagnosis of Sjögren's syndrome is crucial to start the adequate treatment and get better results. It is recommended to include imaging tests in the diagnostic criteria of adolescent and adult SS in order to facilitate the diagnosis at an earlier stage of the disease.

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Oral Nodular Lesions in Patients with Sjögren’s Syndrome: Unusual Oral Implications of a Systemic Disorder

Cited by 4 publications

References 13 publications

Sjögren’s syndrome and ranula development

Sjögren’s syndrome and ranula development

Superficial mucoceles in cancer patients: a retrospective series from a Stomatology unit

Ranula as an early symptom of Sjögren’s syndrome

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