Optical coherence tomography findings in conversion disorder: are there any differences in the etiopathogenesis of subtypes?

Abstract

Background: Optical coherence tomography is a contactless and fast neuroimaging method. Previous Studies have observed thinning of the ganglion cell layer and inner plexiform layer in many neurodegenerative diseases. Objective: The aim of this study was to compare the layers of ganglion cell complex in conversion disorder. Methods: This study involved 50 conversion disorder patients and 50 healthy volunteers as the control. The parameters were measured and recorded automatically by a spectral optical coherence tomography device. Results: There was no difference in the retinal nerve fiber layers between the conversion disorder group and the control group (p > 0.05). The left and right choroid layer thickness acquired from three regions of the choroid layer was higher in patients compared with controls (p < 0.05). The ganglion cell layer and inner plexiform layer volumes were also significantly lower in the patient group (p < 0.05). Discussion: These ganglion cell layer and inner plexiform layer findings suggest that neurodegeneration occurs during the course of conversion disorder especially in subtype involved motor component. The choroid seems to be more related to the sensory component and it may be used to determine the active stage of the disease and to monitor inflammatory process like other inflammation markers used in systemic inflammatory diseases.

Comparison of OCT findings of schizophrenia patients using FGA, Clozapine, and SGA other than Clozapine

“…Previous studies have found that RNFL damage can be detected by ophthalmologic examination only after 50% of the ganglion cells were damaged. This shows that the sensitivity of RNFL is low and may explain the absence of any difference between the patient subgroups 41,42 .…”

“…The choroid is one of the tissues with the most vascularization in the human body and is affected by any systemic event affecting the blood flow 41 . Recent studies suggest that the underlying pathogenesis mechanisms of neurodegenerative diseases and mental disorders may be related to neuronal inflammation 42 .…”

A Robustness Study of Machine Learning Based Methods for Macula Detection in Pathological Fundus Images

“… Intensity: the 'ganglion cell Layer' becomes thinner until disappearing in the fovea. Therefore, the macula appears as the darkest region [6] compared to other components of the retina with degradation in intensity until reaching the fovea, as shown in the fundus image of Figure 2(A) and the OCT in Figure 3 [7].  Lack of vessels inside: the macula is an area devoid of retinal vessels [8].…”

Fonksiyonel Nörolojik Semptom Bozukluğunda Bilişsel Davranışçı Tedavinin Bilişsel Hatalar Üzerine Etkisi

“…Fonksiyonel Nörolojik Semptom Bozukluğunda Bilişsel Davranışçı Tedavi GİRİŞ Fonksiyonel nörolojik semptom bozukluğu (FNSD), eski adıyla konversiyon bozukluğu, nörolojik yada başka tıbbi bir hastalıkla açıklanamayan sinir sistemi belirtilerini ifade eder (1). Bununla birlikte belirtiler gerçektir ve ciddi işlevsellik kaybına neden olurlar.…”