Safety and tolerability of controlled-release oxycodone on postoperative pain in patients submitted to the oncologic head and neck surgery

Abstract

Safety and tolerability of controlled-release oxycodone on Safety and tolerability of controlled-release oxycodone on Safety and tolerability of controlled-release oxycodone on Safety and tolerability of controlled-release oxycodone on Safety and tolerability of controlled-release oxycodone on postoperative pain in patients submitted to the oncologic head postoperative pain in patients submitted to the oncologic head postoperative pain in patients submitted to the oncologic head postoperative pain in patients submitted to the oncologic head postoperative pain in patients submitted to the oncologic head and neck surgery and neck surgery and neck surgery and neck surgery and neck surgery Segurança e tolerabilidade da oxicodona de liberação controlada em dores pós-Segurança e tolerabilidade da oxicodona de liberação controlada em dores pós-Segurança e tolerabilidade da oxicodona de liberação controlada em dores pós-Segurança e tolerabilidade da oxicodona de liberação controlada em dores pós-Segurança e tolerabilidade da oxicodona de liberação controlada em dores pós-operatórias em pacientes submetidos à operações oncológicas de cabeça e operatórias em pacientes submetidos à operações oncológicas de cabeça e operatórias em pacientes submetidos à operações oncológicas de cabeça e operatórias em pacientes submetidos à operações oncológicas de cabeça e operatórias em pacientes submetidos à operações oncológicas de cabeça e pescoço pescoço pescoço pescoço pescoço We conducted a prospective, observational and open study, with 83 patients with moderate to severe pain after head and neck oncological operations. All patients received general anesthesia with propofol, fentanyl and sevoflurane. Postoperatively, should they have moderate or severe pain, we began controlled-release oxycodone 20 mg 12/12 b.i.d on the first day and 10 mg b.i.d. on the second. We assessed the frequency and intensity of adverse effects, the intensity of postoperative pain by a verbal numeric scale and the use of rescue analgesia from 12 hours after administration of the drug and between 7 and 13 days after the last oxycodone dose. Results Results ResultsResults Results: The most common adverse events were nausea, vomiting, dizziness, pruritus, insomnia, constipation and urinary retention, most mild. No serious adverse events occurred. In less than 12 hours after the use of oxycodone, there was a significant decrease in the intensity of postoperative pain, which remained until the end of the study. The rescue medication was requested at a higher frequency when the opioid dose was reduced, or after its suspension. Conclusion Conclusion Conclusion Conclusion Conclusion: Controlled release oxycodone showed to be safe and well tolerated and caused a significant decrease in postoperative pain.

Validação de orientações para enfermeiros de um serviço de atendimento domiciliar oncológico: estudo metodológico

“…Considera-se que a maioria dos opioides culmina em efeitos adversos, a morfina apesar de desencadeá-los permanece como de primeira escolha em razão da fácil condução de sintomas com terapias adjuvantes [19]. Podem ser induzidos por opioides: constipação maligna [16,20,21], náuseas e vômitos [19][20][21], tontura, prurido, insônia, retenção urinária [21], alopecia, fadiga, neuropatia sensorial e perda de apetite [20]. Os laxantes osmóticos, estimulantes da mucosa e lubrificantes devem estar associados aos opioides, com antieméticos como a metoclopramida, o haloperidol ou ondansetrona [5].…”

Dolore post-operatorio nei pazienti affetti da neoplasia testa-collo: fattori predittivi ed efficacia della terapia

“…No side effects due to the administration via infusion pump were reported. Therefore, opioids can be considered as the most effective drugs within the series presented, as for other series in the literature 22 .…”

Acetazolamide reduces postoperative pain following laparoscopic inguinal herniorrhaphy

“…Reducing postoperative opioid requirements in the surgical patient is advantageous for several reasons. Cavalcanti et al [9] evaluated the safety of oxycodone for postoperative pain control and found that side effects, including: nausea, dizziness, constipation, and pruritus, occur at significant frequency. Decreasing opioid requirements in surgical patients has also been found to decrease time for return of bowel function as well as hospital length of stay [10,11].…”