2022
DOI: 10.1590/0100-3984.2021.0038
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68Ga-DOTATATE PET/CT versus 111In-octreotide scintigraphy in patients with neuroendocrine tumors: a prospective study

Abstract: Objective: To compare 68Ga-DOTA-DPhe1,Tyr3-octreotate (68Ga-DOTATATE) positron-emission tomography/computed tomography (PET/CT) findings with those of conventional 111In-octreotide scintigraphy in patients with neuroendocrine tumors (NETs). Materials and Methods: This was a single-center prospective study including 41 patients (25 males; mean age, 55.4 years) with biopsy-proven NETs who underwent whole-body 111In-octreotide scintigraphy and whole-body 68Ga-DOTATATE PET/CT. The patients had been referred for t… Show more

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Cited by 5 publications
(5 citation statements)
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“…2 68 Ga-DOTATATE PET/CT imaging has been shown to be superior to 111 In-DTPA-octreotide imaging for the diagnosis and staging of neuroendocrine tumors. [3][4][5] Incidental findings of increased 68 Ga-DOTATATE uptake in the uterus have been previously described. In one case report, a 41-year-old woman with neuroendocrine lung carcinoma underwent a 1-year postsurgical PET/CT follow-up.…”
Section: Figurementioning
confidence: 79%
See 1 more Smart Citation
“…2 68 Ga-DOTATATE PET/CT imaging has been shown to be superior to 111 In-DTPA-octreotide imaging for the diagnosis and staging of neuroendocrine tumors. [3][4][5] Incidental findings of increased 68 Ga-DOTATATE uptake in the uterus have been previously described. In one case report, a 41-year-old woman with neuroendocrine lung carcinoma underwent a 1-year postsurgical PET/CT follow-up.…”
Section: Figurementioning
confidence: 79%
“…In contrast, the spleen, kidneys, and liver showed high uptake levels with SUV max of >7 2 . 68 Ga-DOTATATE PET/CT imaging has been shown to be superior to 111 In-DTPA-octreotide imaging for the diagnosis and staging of neuroendocrine tumors 3–5 . Incidental findings of increased 68 Ga-DOTATATE uptake in the uterus have been previously described.…”
mentioning
confidence: 98%
“…Хорошо известно, что ПЭТ превосходит сцинтиграфию по чувствительности за счет высокой разрешающей способности, а в сочетании с компьютерной томографией (ПЭТ/КТ) или МРТ (ПЭТ/МРТ) открывает возможность идентификации опухолей малых размеров (менее 1 см) [25]. Превосходство ПЭТ/КТ с 68 Ga-DOTA-ТАТЕ и 68 Ga-DOTA-ТОК над сцинтиграфией и ОФЭКТ с 111 In-октреотидом для диагностики нейроэндокринных опухолей подтверждается результатами проведенных исследований [39][40][41].…”
Section: Introductionunclassified
“…How do the findings of Cavicchioli et al ( 8 ) relate to data in the literature? Their findings are in good agreement with the results of a systematic review and meta-analysis published in 2016, in which 68 Ga-DOTATATE PET/CT was compared with 111 In-DTPA-octreotide imaging and conventional imaging for the evaluation of pulmonary and gastroenteropancreatic NETs ( 9 ) .…”
mentioning
confidence: 96%
“…Despite the established clinical value of using 111 In-pentetreotide as a radiotracer, it has some shortcomings, including a high radiation burden, less than optimal spatial resolution (i.e., less ability to detect small lesions), longer image acquisition time, some accumulation in the intestine/gallbladder, and less availability ( 7 ) . In an article published in the previous issue of Radiologia Brasileira, Cavicchioli et al ( 8 ) compared the use of 68 Ga-DOTA-D-Phe 1 ,Tyr 3 -octreotate ( 68 Ga-DOTATATE) positron-emission tomography/computed tomography (PET/CT) with that of 111 In-octreotide scintigraphy in 41 patients with NETs. Images were compared in a patient-by-patient analysis to identify additional lesions and determine their impact on clinical management.…”
mentioning
confidence: 99%